TRH

Gene Name		thyrotropin-releasing hormone
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Extracellular Region Nucleus Plasma Membrane Secretory Granule
	Molecular Function	Neuropeptide Hormone Activity Thyrotropin-releasing Hormone Activity
	Biological Process	Response To Hypoxia Histamine Metabolic Process Signal Transduction Cell-cell Signaling Adult Walking Behavior Response To Cold Response To Glucose Hormone-mediated Signaling Pathway Negative Regulation Of Glutamate Secretion Positive Regulation Of Gamma-aminobutyric Acid Secretion Positive Regulation Of Insulin Secretion Eating Behavior Response To Ethanol Response To Corticosterone Negative Regulation Of Feeding Behavior
Pathways		Defective ACTH causes Obesity and Pro-opiomelanocortinin deficiency (POMCD) G alpha (q) signalling events G alpha (q) signalling events Signaling by GPCR GPCR downstream signaling Peptide ligand-binding receptors Gastrin-CREB signalling pathway via PKC and MAPK Class A/1 (Rhodopsin-like receptors) Metabolic disorders of biological oxidation enzymes GPCR ligand binding
Drugs
Diseases
GWAS
Protein-protein Interactions		3 interactors: ARRB2 CPE TRHR
Entrez ID		7200
HPRD ID		08944
Ensembl ID		ENSG00000170893
Uniprot IDs		P20396
PDB IDs
Enriched GO Terms of Interacting Partners?		G-protein Coupled Receptor Signaling Pathway Desensitization Of G-protein Coupled Receptor Protein Signaling Pathway By Arrestin Negative Regulation Of Natural Killer Cell Mediated Cytotoxicity Follicle-stimulating Hormone Signaling Pathway Insulin Processing Negative Regulation Of Smooth Muscle Cell Apoptotic Process Positive Regulation Of Synaptic Transmission, Dopaminergic Insulin Metabolic Process Regulation Of Smooth Muscle Cell Apoptotic Process G-protein Coupled Receptor Internalization Negative Regulation Of Interleukin-1 Beta Production Detection Of Temperature Stimulus Involved In Sensory Perception Of Pain Cardiac Left Ventricle Morphogenesis Negative Regulation Of Release Of Cytochrome C From Mitochondria Regulation Of Synaptic Transmission, Dopaminergic Desensitization Of G-protein Coupled Receptor Protein Signaling Pathway Positive Regulation Of Receptor Internalization Positive Regulation Of DNA Biosynthetic Process Cell Surface Receptor Signaling Pathway Negative Regulation Of Interleukin-12 Production Regulation Of Androgen Receptor Signaling Pathway Regulation Of Natural Killer Cell Mediated Cytotoxicity Regulation Of Natural Killer Cell Mediated Immunity Negative Regulation Of Toll-like Receptor Signaling Pathway Detection Of Temperature Stimulus Regulation Of Receptor Internalization Sensory Perception Of Temperature Stimulus Negative Regulation Of Mitochondrion Organization Negative Regulation Of GTPase Activity Peptide Hormone Processing Negative Regulation Of Muscle Cell Apoptotic Process Negative Regulation Of Interleukin-6 Production Positive Regulation Of Receptor-mediated Endocytosis Negative Regulation Of Innate Immune Response Negative Regulation Of Tumor Necrosis Factor Production Regulation Of Toll-like Receptor Signaling Pathway Negative Regulation Of Tumor Necrosis Factor Superfamily Cytokine Production Receptor Internalization Regulation Of DNA Biosynthetic Process Adult Walking Behavior Regulation Of Interleukin-1 Beta Production Regulation Of Muscle Cell Apoptotic Process Negative Regulation Of Protein Binding Regulation Of Intracellular Steroid Hormone Receptor Signaling Pathway Regulation Of Interleukin-12 Production Negative Regulation Of NF-kappaB Transcription Factor Activity Ovarian Follicle Development Cardiac Ventricle Morphogenesis Positive Regulation Of Peptidyl-serine Phosphorylation Positive Regulation Of Protein Kinase B Signaling
Tagcloud ?		atrophy brainstem cerebellar cerebellum computed cortex disturbance flows frontal ganglia infusion intravenous latency lobe matter olivopontocerebellar opca outside prolongation recorder regional releasing subclinical synax thalamus thyrotropin tomography white xenon