CPE and NTS

Number of citations of the paper that reports this interaction (PMID 8770919)
13

Data Source:
HPRD (in vivo)

		CPE	NTS
Gene Name		carboxypeptidase E	neurotensin
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleus Golgi Apparatus Plasma Membrane Transport Vesicle Membrane Secretory Granule Membrane Extracellular Vesicular Exosome	Extracellular Region Transport Vesicle
	Molecular Function	Carboxypeptidase Activity Metallocarboxypeptidase Activity Zinc Ion Binding Neurexin Family Protein Binding Cell Adhesion Molecule Binding	Neuropeptide Hormone Activity Protein Binding
	Biological Process	Cardiac Left Ventricle Morphogenesis Cellular Protein Modification Process Proteolysis Neuropeptide Signaling Pathway Metabolic Process Insulin Processing Cellular Protein Metabolic Process Protein Localization To Membrane	Signal Transduction Regulation Of Blood Vessel Size
Pathways		Peptide hormone metabolism Insulin processing	Defective ACTH causes Obesity and Pro-opiomelanocortinin deficiency (POMCD) G alpha (q) signalling events G alpha (q) signalling events Signaling by GPCR GPCR downstream signaling Peptide ligand-binding receptors Gastrin-CREB signalling pathway via PKC and MAPK Class A/1 (Rhodopsin-like receptors) Metabolic disorders of biological oxidation enzymes GPCR ligand binding
Drugs		Insulin Regular Insulin, porcine
Diseases
GWAS
Protein-Protein Interactions		17 interactors: BDNF CCK CHD3 GAST GCG GTF3C1 INS LRIF1 MED31 NTS PMCH POLA2 POLDIP2 ROBO2 RPA1 TRH UTP14A	9 interactors: ACE2 ARRB2 CPE MEP1A NLN NTSR1 NTSR2 PREP SORT1
Entrez ID		1363	4922
HPRD ID		00272	08878
Ensembl ID		ENSG00000109472	ENSG00000133636
Uniprot IDs		P16870	P30990 Q6FH20
PDB IDs			2LNE 2LNF 2LNG 2LYW 3F6K
Enriched GO Terms of Interacting Partners?		Feeding Behavior Negative Regulation Of Feeding Behavior Positive Regulation Of Peptide Hormone Secretion Positive Regulation Of Peptide Secretion Behavior Regulation Of Feeding Behavior Positive Regulation Of Hormone Secretion Telomere Maintenance Via Semi-conservative Replication G-protein Coupled Receptor Signaling Pathway Nuclear DNA Replication Telomere Maintenance Via Recombination Regulation Of Cellular Amino Acid Metabolic Process Regulation Of Protein Oligomerization Mitotic Recombination DNA Strand Elongation Involved In DNA Replication Eating Behavior DNA Strand Elongation Telomere Maintenance Via Telomere Lengthening Positive Regulation Of Glucose Metabolic Process Regulation Of Behavior Behavioral Fear Response Neuron Recognition Positive Regulation Of Protein Secretion Regulation Of Cellular Ketone Metabolic Process Regulation Of Insulin Secretion Fear Response Response To Hormone Regulation Of Peptide Hormone Secretion Regulation Of Gluconeogenesis Cellular Response To Hormone Stimulus Response To Anesthetic Response To Fluoxetine Response To L-glutamate Regulation Of Hormone Secretion Regulation Of Synapse Assembly Positive Regulation Of Insulin Secretion Energy Derivation By Oxidation Of Organic Compounds Positive Regulation Of Protein Phosphorylation Positive Regulation Of Peptidyl-serine Phosphorylation Telomere Maintenance Positive Regulation Of Secretion Negative Regulation Of Glycogen Catabolic Process Negative Regulation Of Negative Chemotaxis Positive Regulation Of Protein Transport Multicellular Organismal Response To Stress Regulation Of Synapse Organization Regulation Of Synapse Structure Or Activity Taste Bud Development Apoptotic Process Involved In Luteolysis Dendrite Extension	Neuropeptide Signaling Pathway Proteolysis G-protein Coupled Receptor Signaling Pathway Peptide Hormone Processing Receptor Metabolic Process Desensitization Of G-protein Coupled Receptor Protein Signaling Pathway By Arrestin Adult Locomotory Behavior Digestion Angiotensin-mediated Drinking Behavior Angiotensin Catabolic Process In Blood Behavior Peptide Metabolic Process Multicellular Organismal Protein Catabolic Process Adult Behavior Receptor-mediated Virion Attachment To Host Cell Negative Regulation Of Natural Killer Cell Mediated Cytotoxicity Follicle-stimulating Hormone Signaling Pathway Insulin Processing Negative Regulation Of Smooth Muscle Cell Apoptotic Process Multicellular Organismal Protein Metabolic Process Hormone Metabolic Process Endosome Transport Via Multivesicular Body Sorting Pathway Receptor Biosynthetic Process Drinking Behavior Virion Attachment To Host Cell Positive Regulation Of Synaptic Transmission, Dopaminergic Negative Regulation Of Lipoprotein Lipase Activity Plasma Membrane To Endosome Transport Cell Surface Receptor Signaling Pathway Glucose Import Brain Renin-angiotensin System Locomotory Behavior Protein Processing Insulin Metabolic Process Adhesion Of Symbiont To Host Cellular Amide Metabolic Process Regulation Of Hormone Levels Angiotensin Maturation Regulation Of Angiotensin Metabolic Process Regulation Of Smooth Muscle Cell Apoptotic Process Peptide Catabolic Process Regulation Of Blood Volume By Renin-angiotensin G-protein Coupled Receptor Internalization Negative Regulation Of Interleukin-1 Beta Production Nerve Growth Factor Signaling Pathway Regulation Of Systemic Arterial Blood Pressure By Circulatory Renin-angiotensin Detection Of Temperature Stimulus Involved In Sensory Perception Of Pain Cardiac Left Ventricle Morphogenesis Negative Regulation Of Release Of Cytochrome C From Mitochondria Regulation Of Synaptic Transmission, Dopaminergic
Tagcloud ?		attenuating chimera chimeras cytopathic flanked glycoproteins hamsters hemagglutinin hn illustrated lies llc measles neuraminidase noncytopathic nontranslated noteworthy parainfluenza parent piv1 piv2 piv3 presumed replicates resembles rpiv3 somatitis staged virion	acts autocrine cascades competing directed document embedded gxkkxxk homopolymeric localizes mediator mid motif mutagenesis nucleolin nucleolus paracrine parathyroid predict preservation pthrp representing ribonucleoprotein rna rnas salt secreted shared translated
Tagcloud (Difference) ?		attenuating chimera chimeras cytopathic flanked glycoproteins hamsters hemagglutinin hn illustrated lies llc measles neuraminidase noncytopathic nontranslated noteworthy parainfluenza parent piv1 piv2 piv3 presumed replicates resembles rpiv3 somatitis staged virion	acts autocrine cascades competing directed document embedded gxkkxxk homopolymeric localizes mediator mid motif mutagenesis nucleolin nucleolus paracrine parathyroid predict preservation pthrp representing ribonucleoprotein rna rnas salt secreted shared translated
Tagcloud (Intersection) ?