TRH and ARRB2

Number of citations of the paper that reports this interaction (PMID 12473660)
67

Data Source:
HPRD (in vitro, in vivo)

		TRH	ARRB2
Gene Name		thyrotropin-releasing hormone	arrestin, beta 2
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Extracellular Region Nucleus Plasma Membrane Secretory Granule	Nucleus Cytoplasm Cytosol Plasma Membrane Coated Pit Postsynaptic Density Basolateral Plasma Membrane Endocytic Vesicle Cytoplasmic Vesicle Dendritic Spine Postsynaptic Membrane
	Molecular Function	Neuropeptide Hormone Activity Thyrotropin-releasing Hormone Activity	G-protein Coupled Receptor Binding Receptor Binding Protein Binding Enzyme Binding Protein Domain Specific Binding Ubiquitin Protein Ligase Binding Alpha-1A Adrenergic Receptor Binding Alpha-1B Adrenergic Receptor Binding Angiotensin Receptor Binding Type 1 Angiotensin Receptor Binding D1 Dopamine Receptor Binding Follicle-stimulating Hormone Receptor Binding Type 2A Serotonin Receptor Binding Protein Complex Binding Protein Complex Scaffold Protein Kinase B Binding Mitogen-activated Protein Kinase Binding 14-3-3 Protein Binding
	Biological Process	Response To Hypoxia Histamine Metabolic Process Signal Transduction Cell-cell Signaling Adult Walking Behavior Response To Cold Response To Glucose Hormone-mediated Signaling Pathway Negative Regulation Of Glutamate Secretion Positive Regulation Of Gamma-aminobutyric Acid Secretion Positive Regulation Of Insulin Secretion Eating Behavior Response To Ethanol Response To Corticosterone Negative Regulation Of Feeding Behavior	G-protein Coupled Receptor Internalization Desensitization Of G-protein Coupled Receptor Protein Signaling Pathway By Arrestin Positive Regulation Of Receptor Internalization Transcription From RNA Polymerase II Promoter Transforming Growth Factor Beta Receptor Signaling Pathway Notch Signaling Pathway Brain Development Blood Coagulation Adult Walking Behavior Protein Transport Protein Ubiquitination Platelet Activation Negative Regulation Of Protein Ubiquitination Positive Regulation Of Protein Ubiquitination Receptor Internalization Negative Regulation Of NF-kappaB Transcription Factor Activity Positive Regulation Of Synaptic Transmission, Dopaminergic Negative Regulation Of Interleukin-1 Beta Production Negative Regulation Of Interleukin-12 Production Negative Regulation Of Interleukin-6 Production Negative Regulation Of Tumor Necrosis Factor Production Positive Regulation Of Peptidyl-serine Phosphorylation Negative Regulation Of Toll-like Receptor Signaling Pathway Negative Regulation Of GTPase Activity Negative Regulation Of Smooth Muscle Cell Apoptotic Process Follicle-stimulating Hormone Signaling Pathway Negative Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of Natural Killer Cell Mediated Cytotoxicity Positive Regulation Of Peptidyl-tyrosine Phosphorylation Detection Of Temperature Stimulus Involved In Sensory Perception Of Pain Positive Regulation Of Protein Kinase B Signaling Positive Regulation Of Calcium Ion Transport Cell Chemotaxis Regulation Of Androgen Receptor Signaling Pathway Positive Regulation Of ERK1 And ERK2 Cascade Negative Regulation Of Release Of Cytochrome C From Mitochondria Positive Regulation Of DNA Biosynthetic Process
Pathways		Defective ACTH causes Obesity and Pro-opiomelanocortinin deficiency (POMCD) G alpha (q) signalling events G alpha (q) signalling events Signaling by GPCR GPCR downstream signaling Peptide ligand-binding receptors Gastrin-CREB signalling pathway via PKC and MAPK Class A/1 (Rhodopsin-like receptors) Metabolic disorders of biological oxidation enzymes GPCR ligand binding	Signaling by NOTCH1 HD Domain Mutants in Cancer Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer Signaling by NOTCH Signaling by Wnt beta-catenin independent WNT signaling Thrombin signalling through proteinase activated receptors (PARs) Activated NOTCH1 Transmits Signal to the Nucleus Signaling by NOTCH1 t(7;9)(NOTCH1:M1580_K2555) Translocation Mutant Hedgehog 'on' state Signaling by NOTCH1 WNT5A-dependent internalization of FZD4 Signaling by Hedgehog Signaling by NOTCH1 PEST Domain Mutants in Cancer Signaling by NOTCH1 in Cancer Platelet activation, signaling and aggregation PCP/CE pathway Activation of SMO FBXW7 Mutants and NOTCH1 in Cancer
Drugs
Diseases
GWAS
Protein-Protein Interactions		3 interactors: ARRB2 CPE TRHR	47 interactors: ADRB2 AGTR1 AP1B1 AP2M1 ARF6 AVPR2 C5AR1 CDC42 CLTC CSNK2A1 CSNK2A2 CXCR4 CYTH2 DVL2 FLNA FZD4 HCRTR1 HIPK3 HTR2C ITCH LHCGR LIMK1 MAP2K4 MAP3K5 MAPK1 MAPK10 MAPK9 MDM2 MED8 NDUFS7 NFKBIA NTS NTSR1 OPRD1 OXTR PARK2 PDE4D PTAFR PTGDS RAF1 RALGDS SLC9A5 SMARCC2 STC2 TGFBR3 TRH USP33
Entrez ID		7200	409
HPRD ID		08944	00147
Ensembl ID		ENSG00000170893	ENSG00000141480
Uniprot IDs		P20396	K7ENA6 P32121 Q59EM5
PDB IDs
Enriched GO Terms of Interacting Partners?		G-protein Coupled Receptor Signaling Pathway Desensitization Of G-protein Coupled Receptor Protein Signaling Pathway By Arrestin Negative Regulation Of Natural Killer Cell Mediated Cytotoxicity Follicle-stimulating Hormone Signaling Pathway Insulin Processing Negative Regulation Of Smooth Muscle Cell Apoptotic Process Positive Regulation Of Synaptic Transmission, Dopaminergic Insulin Metabolic Process Regulation Of Smooth Muscle Cell Apoptotic Process G-protein Coupled Receptor Internalization Negative Regulation Of Interleukin-1 Beta Production Detection Of Temperature Stimulus Involved In Sensory Perception Of Pain Cardiac Left Ventricle Morphogenesis Negative Regulation Of Release Of Cytochrome C From Mitochondria Regulation Of Synaptic Transmission, Dopaminergic Desensitization Of G-protein Coupled Receptor Protein Signaling Pathway Positive Regulation Of Receptor Internalization Positive Regulation Of DNA Biosynthetic Process Cell Surface Receptor Signaling Pathway Negative Regulation Of Interleukin-12 Production Regulation Of Androgen Receptor Signaling Pathway Regulation Of Natural Killer Cell Mediated Cytotoxicity Regulation Of Natural Killer Cell Mediated Immunity Negative Regulation Of Toll-like Receptor Signaling Pathway Detection Of Temperature Stimulus Regulation Of Receptor Internalization Sensory Perception Of Temperature Stimulus Negative Regulation Of Mitochondrion Organization Negative Regulation Of GTPase Activity Peptide Hormone Processing Negative Regulation Of Muscle Cell Apoptotic Process Negative Regulation Of Interleukin-6 Production Positive Regulation Of Receptor-mediated Endocytosis Negative Regulation Of Innate Immune Response Negative Regulation Of Tumor Necrosis Factor Production Regulation Of Toll-like Receptor Signaling Pathway Negative Regulation Of Tumor Necrosis Factor Superfamily Cytokine Production Receptor Internalization Regulation Of DNA Biosynthetic Process Adult Walking Behavior Regulation Of Interleukin-1 Beta Production Regulation Of Muscle Cell Apoptotic Process Negative Regulation Of Protein Binding Regulation Of Intracellular Steroid Hormone Receptor Signaling Pathway Regulation Of Interleukin-12 Production Negative Regulation Of NF-kappaB Transcription Factor Activity Ovarian Follicle Development Cardiac Ventricle Morphogenesis Positive Regulation Of Peptidyl-serine Phosphorylation Positive Regulation Of Protein Kinase B Signaling	Cell Surface Receptor Signaling Pathway Cell Communication Regulation Of Signaling Regulation Of Intracellular Signal Transduction Regulation Of Protein Metabolic Process Regulation Of Cellular Protein Metabolic Process Signaling Signal Transduction Regulation Of Signal Transduction Regulation Of MAPK Cascade Positive Regulation Of Protein Metabolic Process Cellular Response To Stimulus Response To External Stimulus Regulation Of Phosphorus Metabolic Process Positive Regulation Of Cellular Protein Metabolic Process Regulation Of Stress-activated MAPK Cascade Immune Response-regulating Signaling Pathway Intracellular Signal Transduction Cellular Response To Organic Substance Response To Stimulus Positive Regulation Of Signal Transduction Regulation Of Phosphorylation Positive Regulation Of Intracellular Signal Transduction Regulation Of JNK Cascade Response To Organic Substance Positive Regulation Of MAPK Cascade Regulation Of Protein Phosphorylation Chemotaxis Positive Regulation Of Protein Modification Process Regulation Of Catalytic Activity Immune Response-regulating Cell Surface Receptor Signaling Pathway Positive Regulation Of Metabolic Process Positive Regulation Of Phosphorylation Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Positive Regulation Of Protein Phosphorylation Locomotion Immune System Process Regulation Of Metabolic Process Regulation Of Cellular Process Positive Regulation Of Catalytic Activity Positive Regulation Of Kinase Activity Regulation Of Kinase Activity Fc Receptor Signaling Pathway G-protein Coupled Receptor Signaling Pathway Apoptotic Process Response To Stress Positive Regulation Of Cellular Metabolic Process Programmed Cell Death Regulation Of MAP Kinase Activity Response To Lipid
Tagcloud ?		atrophy brainstem cerebellar cerebellum computed cortex disturbance flows frontal ganglia infusion intravenous latency lobe matter olivopontocerebellar opca outside prolongation recorder regional releasing subclinical synax thalamus thyrotropin tomography white xenon	17p13 22q11 adrbk2 adrenergic ark ark1 ark2 arrestin assignment band chromosome coding cofactor coupled desensitization grk4 grk5 grk6 includes it11 mapped mapping multigene occupied phosphorylates q37 refine rhodopsin sag
Tagcloud (Difference) ?		atrophy brainstem cerebellar cerebellum computed cortex disturbance flows frontal ganglia infusion intravenous latency lobe matter olivopontocerebellar opca outside prolongation recorder regional releasing subclinical synax thalamus thyrotropin tomography white xenon	17p13 22q11 adrbk2 adrenergic ark ark1 ark2 arrestin assignment band chromosome coding cofactor coupled desensitization grk4 grk5 grk6 includes it11 mapped mapping multigene occupied phosphorylates q37 refine rhodopsin sag
Tagcloud (Intersection) ?