CPE and GTF3C1

Number of citations of the paper that reports this interaction (PMID 16169070)
531

Data Source:
BioGRID (two hybrid)
HPRD (two hybrid)

		CPE	GTF3C1
Gene Name		carboxypeptidase E	general transcription factor IIIC, polypeptide 1, alpha 220kDa
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleus Golgi Apparatus Plasma Membrane Transport Vesicle Membrane Secretory Granule Membrane Extracellular Vesicular Exosome	Transcription Factor TFIIIC Complex Nucleus Nucleoplasm Nucleolus Membrane Ribonucleoprotein Complex
	Molecular Function	Carboxypeptidase Activity Metallocarboxypeptidase Activity Zinc Ion Binding Neurexin Family Protein Binding Cell Adhesion Molecule Binding	DNA Binding Protein Binding
	Biological Process	Cardiac Left Ventricle Morphogenesis Cellular Protein Modification Process Proteolysis Neuropeptide Signaling Pathway Metabolic Process Insulin Processing Cellular Protein Metabolic Process Protein Localization To Membrane	Transcription, DNA-templated Transcription From RNA Polymerase III Promoter RRNA Transcription TRNA Transcription Gene Expression 5S Class RRNA Transcription From RNA Polymerase III Type 1 Promoter TRNA Transcription From RNA Polymerase III Promoter
Pathways		Peptide hormone metabolism Insulin processing	RNA Polymerase III Transcription RNA Polymerase III Transcription Initiation RNA Polymerase III Transcription Initiation From Type 1 Promoter RNA Polymerase I, RNA Polymerase III, and Mitochondrial Transcription RNA Polymerase III Abortive And Retractive Initiation RNA Polymerase III Transcription Initiation From Type 2 Promoter
Drugs		Insulin Regular Insulin, porcine
Diseases
GWAS
Protein-Protein Interactions		17 interactors: BDNF CCK CHD3 GAST GCG GTF3C1 INS LRIF1 MED31 NTS PMCH POLA2 POLDIP2 ROBO2 RPA1 TRH UTP14A	21 interactors: AGTRAP AKTIP ASCC2 CHN1 CMTM5 CPE CSNK1E DEDD EZH2 FGFR3 GTF3C4 HGH1 IGFBP3 KLF6 MAGEA4 MAPK10 NHP2L1 PRPF38A RBM23 SUPT5H TBC1D17
Entrez ID		1363	2975
HPRD ID		00272	07540
Ensembl ID		ENSG00000109472	ENSG00000077235
Uniprot IDs		P16870	Q12789
PDB IDs
Enriched GO Terms of Interacting Partners?		Feeding Behavior Negative Regulation Of Feeding Behavior Positive Regulation Of Peptide Hormone Secretion Positive Regulation Of Peptide Secretion Behavior Regulation Of Feeding Behavior Positive Regulation Of Hormone Secretion Telomere Maintenance Via Semi-conservative Replication G-protein Coupled Receptor Signaling Pathway Nuclear DNA Replication Telomere Maintenance Via Recombination Regulation Of Cellular Amino Acid Metabolic Process Regulation Of Protein Oligomerization Mitotic Recombination DNA Strand Elongation Involved In DNA Replication Eating Behavior DNA Strand Elongation Telomere Maintenance Via Telomere Lengthening Positive Regulation Of Glucose Metabolic Process Regulation Of Behavior Behavioral Fear Response Neuron Recognition Positive Regulation Of Protein Secretion Regulation Of Cellular Ketone Metabolic Process Regulation Of Insulin Secretion Fear Response Response To Hormone Regulation Of Peptide Hormone Secretion Regulation Of Gluconeogenesis Cellular Response To Hormone Stimulus Response To Anesthetic Response To Fluoxetine Response To L-glutamate Regulation Of Hormone Secretion Regulation Of Synapse Assembly Positive Regulation Of Insulin Secretion Energy Derivation By Oxidation Of Organic Compounds Positive Regulation Of Protein Phosphorylation Positive Regulation Of Peptidyl-serine Phosphorylation Telomere Maintenance Positive Regulation Of Secretion Negative Regulation Of Glycogen Catabolic Process Negative Regulation Of Negative Chemotaxis Positive Regulation Of Protein Transport Multicellular Organismal Response To Stress Regulation Of Synapse Organization Regulation Of Synapse Structure Or Activity Taste Bud Development Apoptotic Process Involved In Luteolysis Dendrite Extension	Positive Regulation Of Metabolic Process Regulation Of Circadian Rhythm Negative Regulation Of DNA-templated Transcription, Elongation Positive Regulation Of Catalytic Activity Regulation Of Muscle Cell Differentiation MRNA Processing Positive Regulation Of MAPK Cascade Positive Regulation Of Signal Transduction Regulation Of Myoblast Differentiation Positive Regulation Of Phosphorylation Negative Regulation Of Muscle Cell Differentiation RNA Metabolic Process Positive Regulation Of Cellular Metabolic Process Fibroblast Growth Factor Receptor Apoptotic Signaling Pathway Regulation Of DNA-templated Transcription, Elongation MRNA Metabolic Process RNA Processing Cellular Nitrogen Compound Metabolic Process Gene Expression Cellular Metabolic Process Regulation Of MAPK Cascade Single Stranded Viral RNA Replication Via Double Stranded DNA Intermediate Regulation Of Protein Metabolic Process Regulation Of Protein Phosphorylation Positive Regulation Of Cellular Protein Metabolic Process Negative Regulation Of Transcription Of Nuclear Large RRNA Transcript From RNA Polymerase I Promoter Nucleobase-containing Compound Metabolic Process Regulation Of Intracellular Signal Transduction Regulation Of Catalytic Activity Nitrogen Compound Metabolic Process Positive Regulation Of Protein Phosphorylation Cell Surface Receptor Signaling Pathway Regulation Of Metabolic Process Positive Regulation Of Protein Metabolic Process Skeletal Muscle Satellite Cell Maintenance Involved In Skeletal Muscle Regeneration Regulation Of Gliogenesis Heterocycle Metabolic Process Extrinsic Apoptotic Signaling Pathway Cellular Aromatic Compound Metabolic Process Cellular Protein Modification Process Insulin Processing Regulation Of Phosphorylation Positive Regulation Of Intracellular Signal Transduction Alveolar Secondary Septum Development 5S Class RRNA Transcription From RNA Polymerase III Type 1 Promoter TRNA Transcription From RNA Polymerase III Promoter JUN Phosphorylation Positive Regulation Of Canonical Wnt Signaling Pathway Regulation Of Cellular Protein Metabolic Process Axonogenesis Involved In Innervation
Tagcloud ?		attenuating chimera chimeras cytopathic flanked glycoproteins hamsters hemagglutinin hn illustrated lies llc measles neuraminidase noncytopathic nontranslated noteworthy parainfluenza parent piv1 piv2 piv3 presumed replicates resembles rpiv3 somatitis staged virion
Tagcloud (Difference) ?		attenuating chimera chimeras cytopathic flanked glycoproteins hamsters hemagglutinin hn illustrated lies llc measles neuraminidase noncytopathic nontranslated noteworthy parainfluenza parent piv1 piv2 piv3 presumed replicates resembles rpiv3 somatitis staged virion
Tagcloud (Intersection) ?