C3 and CR1

Number of citations of the paper that reports this interaction (PMID 9988761)
6

Data Source:
HPRD (in vivo, in vitro)

		C3	CR1
Gene Name		complement component 3	complement component (3b/4b) receptor 1 (Knops blood group)
Image
Gene Ontology Annotations	Cellular Component	Extracellular Region Extracellular Space Plasma Membrane Extracellular Vesicular Exosome Blood Microparticle	Plasma Membrane Integral Component Of Plasma Membrane Cell Surface Extracellular Vesicular Exosome
	Molecular Function	Endopeptidase Inhibitor Activity Receptor Binding Protein Binding C5L2 Anaphylatoxin Chemotactic Receptor Binding	Complement Component C3b Binding Complement Component C4b Binding Complement Component C4b Receptor Activity Complement Component C3b Receptor Activity
	Biological Process	Positive Regulation Of Type IIa Hypersensitivity Positive Regulation Of Protein Phosphorylation Positive Regulation Of Activation Of Membrane Attack Complex Fatty Acid Metabolic Process Inflammatory Response Immune Response Complement Activation Complement Activation, Alternative Pathway Complement Activation, Classical Pathway Signal Transduction G-protein Coupled Receptor Signaling Pathway Positive Regulation Vascular Endothelial Growth Factor Production Positive Regulation Of Glucose Transport Regulation Of Triglyceride Biosynthetic Process Positive Regulation Of Lipid Storage Negative Regulation Of Endopeptidase Activity Regulation Of Complement Activation Innate Immune Response Positive Regulation Of G-protein Coupled Receptor Protein Signaling Pathway Positive Regulation Of Angiogenesis Regulation Of Immune Response Positive Regulation Of Apoptotic Cell Clearance	Complement Receptor Mediated Signaling Pathway Complement Activation, Classical Pathway Regulation Of Complement Activation Innate Immune Response Negative Regulation Of Complement Activation, Alternative Pathway Negative Regulation Of Complement Activation, Classical Pathway Negative Regulation Of Serine-type Endopeptidase Activity Positive Regulation Of Serine-type Endopeptidase Activity
Pathways		Defective ACTH causes Obesity and Pro-opiomelanocortinin deficiency (POMCD) Signaling by GPCR Alternative complement activation Class A/1 (Rhodopsin-like receptors) Activation of C3 and C5 Metabolic disorders of biological oxidation enzymes GPCR ligand binding Initial triggering of complement GPCR downstream signaling Peptide ligand-binding receptors Regulation of Complement cascade Complement cascade G alpha (i) signalling events Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell Adaptive Immune System Innate Immune System	Regulation of Complement cascade Complement cascade Innate Immune System
Drugs
Diseases
GWAS		Age-related macular degeneration ( 20385819 20385826 23455636 20861866 21665990) Age-related macular degeneration (CNV) ( 22705344) Age-related macular degeneration (GA) ( 22705344) Complement C3 and C4 levels ( 23028341)	Alzheimer's disease ( 21460840 19734903) Alzheimer's disease (late onset) ( 21460841) Erythrocyte sedimentation rate ( 21700265) Inflammatory biomarkers ( 22291609)
Protein-Protein Interactions		27 interactors: ABL1 C2 C3AR1 C5 C5AR2 CD46 CFB CFH CFHR3 CFHR4 CFHR5 CFI CFP CPN1 CR1 CR2 CTSG GC ITGAM ITGAX LAMA1 LRP1 MASP1 OLFM4 PAPPA TGM2 VSIG4	6 interactors: C1QA C3 C4A CD55 CR2 FUT4
Entrez ID		718	1378
HPRD ID		00400	00398
Ensembl ID		ENSG00000125730	ENSG00000203710
Uniprot IDs		P01024	E9PDY4 P17927
PDB IDs		1C3D 1GHQ 1W2S 2A73 2A74 2GOX 2HR0 2I07 2ICE 2ICF 2NOJ 2QKI 2WII 2WIN 2WY7 2WY8 2XQW 2XWB 2XWJ 3D5R 3D5S 3G6J 3L3O 3L5N 3NMS 3OED 3OHX 3OXU 3RJ3 3T4A 4HW5 4HWJ 4I6O 4M76	1GKG 1GKN 1GOP 1PPQ 2Q7Z
Enriched GO Terms of Interacting Partners?		Complement Activation Regulation Of Complement Activation Protein Activation Cascade Positive Regulation Of Immune Response Regulation Of Immune Response Regulation Of Humoral Immune Response Humoral Immune Response Regulation Of Immune System Process Defense Response Regulation Of Acute Inflammatory Response Positive Regulation Of Immune System Process Complement Activation, Alternative Pathway Regulation Of Inflammatory Response Innate Immune Response Immune Response Immune System Process Response To Stress Regulation Of Protein Processing Complement Activation, Classical Pathway Humoral Immune Response Mediated By Circulating Immunoglobulin Complement Receptor Mediated Signaling Pathway Leukocyte Mediated Immunity Response To Stimulus Immunoglobulin Mediated Immune Response B Cell Mediated Immunity Protein Metabolic Process Negative Regulation Of Immune System Process Adaptive Immune Response Based On Somatic Recombination Of Immune Receptors Built From Immunoglobulin Superfamily Domains Adaptive Immune Response Negative Regulation Of Complement Activation Regulation Of Protein Metabolic Process Response To External Stimulus Regulation Of Cytokine Production Negative Regulation Of Immune Response Negative Regulation Of Leukocyte Chemotaxis Chemotaxis Regulation Of Cell Adhesion Regulation Of Cell Motility Regulation Of Locomotion Regulation Of Cellular Component Movement Regulation Of Macrophage Chemotaxis Immune Response-regulating Signaling Pathway Proteolysis Leukocyte Migration Involved In Inflammatory Response Cell Surface Receptor Signaling Pathway Immune Response-activating Cell Surface Receptor Signaling Pathway Regulation Of Leukocyte Migration Cellular Calcium Ion Homeostasis Lymphocyte Proliferation Locomotion	Complement Activation, Classical Pathway Humoral Immune Response Mediated By Circulating Immunoglobulin Complement Activation Protein Activation Cascade Immunoglobulin Mediated Immune Response B Cell Mediated Immunity Humoral Immune Response Adaptive Immune Response Based On Somatic Recombination Of Immune Receptors Built From Immunoglobulin Superfamily Domains Leukocyte Mediated Immunity Adaptive Immune Response Regulation Of Complement Activation Positive Regulation Of Immune Response Regulation Of Humoral Immune Response Innate Immune Response Regulation Of Immune Response Positive Regulation Of Immune System Process Regulation Of Acute Inflammatory Response Positive Regulation Of Apoptotic Cell Clearance Regulation Of Apoptotic Cell Clearance Immune Response Regulation Of Immune System Process Defense Response Regulation Of Inflammatory Response Immune System Process Positive Regulation Of Phagocytosis Negative Regulation Of Protein Processing Regulation Of Protein Processing Regulation Of Phagocytosis Protein Metabolic Process Positive Regulation Of Endocytosis Response To Stress Positive Regulation Of CD4-positive, Alpha-beta T Cell Proliferation Positive Regulation Of Type IIa Hypersensitivity Negative Regulation Of Catalytic Activity CD4-positive, Alpha-beta T Cell Cytokine Production Regulation Of Endocytosis Positive Regulation Of Activation Of Membrane Attack Complex Negative Regulation Of Protein Metabolic Process Complement Receptor Mediated Signaling Pathway Positive Regulation Of Hypersensitivity Negative Regulation Of Endopeptidase Activity Negative Regulation Of Peptidase Activity L-fucose Catabolic Process Positive Regulation Of Acute Inflammatory Response To Antigenic Stimulus Maternal Process Involved In Parturition T Cell Cytokine Production Complement Activation, Alternative Pathway Positive Regulation Of Inflammatory Response To Antigenic Stimulus Respiratory Burst Negative Regulation Of Proteolysis
Tagcloud ?		accordance antioxidants asp assignment boc buckminsterfullerene c60 carboxyfullerene carboxyfullerenes collapse dopaminergic dugan dyes entirely fluoromethylketone fluorophores hoc hydroxydopamine hydroxylase neurotoxin neurotrophic ohda oxidized phenylpyridinium radicals ros saved temporally toxins	abmt allogeneic apbct bmt cml consolidation curves dfs entirely hd infiltration kaplan localisation meier nhl nodal offers postponed relapse relapsed relapsing saa salvage spleen stepwise testis transplanted unfavourable
Tagcloud (Difference) ?		accordance antioxidants asp assignment boc buckminsterfullerene c60 carboxyfullerene carboxyfullerenes collapse dopaminergic dugan dyes fluoromethylketone fluorophores hoc hydroxydopamine hydroxylase neurotoxin neurotrophic ohda oxidized phenylpyridinium radicals ros saved temporally toxins	abmt allogeneic apbct bmt cml consolidation curves dfs hd infiltration kaplan localisation meier nhl nodal offers postponed relapse relapsed relapsing saa salvage spleen stepwise testis transplanted unfavourable
Tagcloud (Intersection) ?		entirely