CR1

Gene Name		complement component (3b/4b) receptor 1 (Knops blood group)
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Gene Ontology Annotations	Cellular Component	Plasma Membrane Integral Component Of Plasma Membrane Cell Surface Extracellular Vesicular Exosome
	Molecular Function	Complement Component C3b Binding Complement Component C4b Binding Complement Component C4b Receptor Activity Complement Component C3b Receptor Activity
	Biological Process	Complement Receptor Mediated Signaling Pathway Complement Activation, Classical Pathway Regulation Of Complement Activation Innate Immune Response Negative Regulation Of Complement Activation, Alternative Pathway Negative Regulation Of Complement Activation, Classical Pathway Negative Regulation Of Serine-type Endopeptidase Activity Positive Regulation Of Serine-type Endopeptidase Activity
Pathways		Regulation of Complement cascade Complement cascade Innate Immune System
Drugs
Diseases
GWAS		Alzheimer's disease ( 21460840 19734903) Alzheimer's disease (late onset) ( 21460841) Erythrocyte sedimentation rate ( 21700265) Inflammatory biomarkers ( 22291609)
Protein-protein Interactions		6 interactors: C1QA C3 C4A CD55 CR2 FUT4
Entrez ID		1378
HPRD ID		00398
Ensembl ID		ENSG00000203710
Uniprot IDs		E9PDY4 P17927
PDB IDs		1GKG 1GKN 1GOP 1PPQ 2Q7Z
Enriched GO Terms of Interacting Partners?		Complement Activation, Classical Pathway Humoral Immune Response Mediated By Circulating Immunoglobulin Complement Activation Protein Activation Cascade Immunoglobulin Mediated Immune Response B Cell Mediated Immunity Humoral Immune Response Adaptive Immune Response Based On Somatic Recombination Of Immune Receptors Built From Immunoglobulin Superfamily Domains Leukocyte Mediated Immunity Adaptive Immune Response Regulation Of Complement Activation Positive Regulation Of Immune Response Regulation Of Humoral Immune Response Innate Immune Response Regulation Of Immune Response Positive Regulation Of Immune System Process Regulation Of Acute Inflammatory Response Positive Regulation Of Apoptotic Cell Clearance Regulation Of Apoptotic Cell Clearance Immune Response Regulation Of Immune System Process Defense Response Regulation Of Inflammatory Response Immune System Process Positive Regulation Of Phagocytosis Negative Regulation Of Protein Processing Regulation Of Protein Processing Regulation Of Phagocytosis Protein Metabolic Process Positive Regulation Of Endocytosis Response To Stress Positive Regulation Of CD4-positive, Alpha-beta T Cell Proliferation Positive Regulation Of Type IIa Hypersensitivity Negative Regulation Of Catalytic Activity CD4-positive, Alpha-beta T Cell Cytokine Production Regulation Of Endocytosis Positive Regulation Of Activation Of Membrane Attack Complex Negative Regulation Of Protein Metabolic Process Complement Receptor Mediated Signaling Pathway Positive Regulation Of Hypersensitivity Negative Regulation Of Endopeptidase Activity Negative Regulation Of Peptidase Activity L-fucose Catabolic Process Positive Regulation Of Acute Inflammatory Response To Antigenic Stimulus Maternal Process Involved In Parturition T Cell Cytokine Production Complement Activation, Alternative Pathway Positive Regulation Of Inflammatory Response To Antigenic Stimulus Respiratory Burst Negative Regulation Of Proteolysis
Tagcloud ?		abmt allogeneic apbct bmt cml consolidation curves dfs entirely hd infiltration kaplan localisation meier nhl nodal offers postponed relapse relapsed relapsing saa salvage spleen stepwise testis transplanted unfavourable