C3 and CD46

Number of citations of the paper that reports this interaction (PMID 1717583)
32

Data Source:
HPRD (in vitro)

		C3	CD46
Gene Name		complement component 3	CD46 molecule, complement regulatory protein
Image
Gene Ontology Annotations	Cellular Component	Extracellular Region Extracellular Space Plasma Membrane Extracellular Vesicular Exosome Blood Microparticle	Inner Acrosomal Membrane Golgi Apparatus Plasma Membrane Integral Component Of Plasma Membrane Focal Adhesion Cell Surface Basolateral Plasma Membrane Extracellular Vesicular Exosome
	Molecular Function	Endopeptidase Inhibitor Activity Receptor Binding Protein Binding C5L2 Anaphylatoxin Chemotactic Receptor Binding	Complement Binding Endopeptidase Activity Enzyme Inhibitor Activity Receptor Activity Protein Binding Cadherin Binding
	Biological Process	Positive Regulation Of Type IIa Hypersensitivity Positive Regulation Of Protein Phosphorylation Positive Regulation Of Activation Of Membrane Attack Complex Fatty Acid Metabolic Process Inflammatory Response Immune Response Complement Activation Complement Activation, Alternative Pathway Complement Activation, Classical Pathway Signal Transduction G-protein Coupled Receptor Signaling Pathway Positive Regulation Vascular Endothelial Growth Factor Production Positive Regulation Of Glucose Transport Regulation Of Triglyceride Biosynthetic Process Positive Regulation Of Lipid Storage Negative Regulation Of Endopeptidase Activity Regulation Of Complement Activation Innate Immune Response Positive Regulation Of G-protein Coupled Receptor Protein Signaling Pathway Positive Regulation Of Angiogenesis Regulation Of Immune Response Positive Regulation Of Apoptotic Cell Clearance	Adaptive Immune Response T Cell Mediated Immunity Proteolysis Complement Activation, Classical Pathway Single Fertilization Regulation Of Notch Signaling Pathway Positive Regulation Of Gene Expression Negative Regulation Of Gene Expression Viral Process Regulation Of Complement Activation Interleukin-10 Production Positive Regulation Of Interleukin-10 Production Sequestering Of Extracellular Ligand From Receptor Positive Regulation Of T Cell Proliferation Negative Regulation Of Catalytic Activity Positive Regulation Of Memory T Cell Differentiation Innate Immune Response Positive Regulation Of Regulatory T Cell Differentiation Negative Regulation Of Complement Activation Positive Regulation Of Transforming Growth Factor Beta Production
Pathways		Defective ACTH causes Obesity and Pro-opiomelanocortinin deficiency (POMCD) Signaling by GPCR Alternative complement activation Class A/1 (Rhodopsin-like receptors) Activation of C3 and C5 Metabolic disorders of biological oxidation enzymes GPCR ligand binding Initial triggering of complement GPCR downstream signaling Peptide ligand-binding receptors Regulation of Complement cascade Complement cascade G alpha (i) signalling events Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell Adaptive Immune System Innate Immune System	Regulation of Complement cascade Complement cascade Innate Immune System
Drugs
Diseases
GWAS		Age-related macular degeneration ( 20385819 20385826 23455636 20861866 21665990) Age-related macular degeneration (CNV) ( 22705344) Age-related macular degeneration (GA) ( 22705344) Complement C3 and C4 levels ( 23028341)	Age-related macular degeneration ( 23326517) Biomedical quantitative traits ( 19396169) Heart rate ( 23583979) Obesity-related traits ( 23251661)
Protein-Protein Interactions		27 interactors: ABL1 C2 C3AR1 C5 C5AR2 CD46 CFB CFH CFHR3 CFHR4 CFHR5 CFI CFP CPN1 CR1 CR2 CTSG GC ITGAM ITGAX LAMA1 LRP1 MASP1 OLFM4 PAPPA TGM2 VSIG4	8 interactors: C3 DLG4 ITGB1 LLGL1 MSN SRC TSPAN4 YES1
Entrez ID		718	4179
HPRD ID		00400	00406
Ensembl ID		ENSG00000125730	ENSG00000117335
Uniprot IDs		P01024	P15529
PDB IDs		1C3D 1GHQ 1W2S 2A73 2A74 2GOX 2HR0 2I07 2ICE 2ICF 2NOJ 2QKI 2WII 2WIN 2WY7 2WY8 2XQW 2XWB 2XWJ 3D5R 3D5S 3G6J 3L3O 3L5N 3NMS 3OED 3OHX 3OXU 3RJ3 3T4A 4HW5 4HWJ 4I6O 4M76	1CKL 1HR4 2O39 3INB 3L89 3O8E
Enriched GO Terms of Interacting Partners?		Complement Activation Regulation Of Complement Activation Protein Activation Cascade Positive Regulation Of Immune Response Regulation Of Immune Response Regulation Of Humoral Immune Response Humoral Immune Response Regulation Of Immune System Process Defense Response Regulation Of Acute Inflammatory Response Positive Regulation Of Immune System Process Complement Activation, Alternative Pathway Regulation Of Inflammatory Response Innate Immune Response Immune Response Immune System Process Response To Stress Regulation Of Protein Processing Complement Activation, Classical Pathway Humoral Immune Response Mediated By Circulating Immunoglobulin Complement Receptor Mediated Signaling Pathway Leukocyte Mediated Immunity Response To Stimulus Immunoglobulin Mediated Immune Response B Cell Mediated Immunity Protein Metabolic Process Negative Regulation Of Immune System Process Adaptive Immune Response Based On Somatic Recombination Of Immune Receptors Built From Immunoglobulin Superfamily Domains Adaptive Immune Response Negative Regulation Of Complement Activation Regulation Of Protein Metabolic Process Response To External Stimulus Regulation Of Cytokine Production Negative Regulation Of Immune Response Negative Regulation Of Leukocyte Chemotaxis Chemotaxis Regulation Of Cell Adhesion Regulation Of Cell Motility Regulation Of Locomotion Regulation Of Cellular Component Movement Regulation Of Macrophage Chemotaxis Immune Response-regulating Signaling Pathway Proteolysis Leukocyte Migration Involved In Inflammatory Response Cell Surface Receptor Signaling Pathway Immune Response-activating Cell Surface Receptor Signaling Pathway Regulation Of Leukocyte Migration Cellular Calcium Ion Homeostasis Lymphocyte Proliferation Locomotion	Regulation Of Endocytosis Axonogenesis Axon Development Cell Morphogenesis Involved In Neuron Differentiation Leukocyte Migration Neuron Projection Morphogenesis Cell Morphogenesis Involved In Differentiation Maintenance Of Apical/basal Cell Polarity Neuron Projection Development Cell Projection Morphogenesis Cell Part Morphogenesis Regulation Of Vesicle-mediated Transport Axon Guidance Cell Development Neuron Development Maintenance Of Cell Polarity Cell Morphogenesis Negative Regulation Of Anoikis Neuron Differentiation Cell Projection Organization Regulation Of Anoikis Locomotion Cellular Response To Platelet-derived Growth Factor Stimulus Response To Platelet-derived Growth Factor Regulation Of Immune System Process Actin Cytoskeleton Organization Chemotaxis Cortical Actin Cytoskeleton Organization Actin Filament-based Process Establishment Or Maintenance Of Apical/basal Cell Polarity Cortical Cytoskeleton Organization Movement Of Cell Or Subcellular Component Regulation Of Vascular Permeability Generation Of Neurons Golgi To Plasma Membrane Transport Peptidyl-tyrosine Autophosphorylation Neurogenesis Cell Migration Regulation Of Immune Response Cell Motility Cellular Component Assembly Cell Differentiation Positive Regulation Of Metabolic Process Positive Regulation Of Cell Adhesion Protein Complex Assembly Dendrite Morphogenesis Immune System Process T Cell Costimulation Blood Coagulation Cytoskeleton Organization
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Tagcloud (Difference) ?		accordance antioxidants asp assignment boc buckminsterfullerene c60 carboxyfullerene carboxyfullerenes collapse dopaminergic dugan dyes entirely fluoromethylketone fluorophores hoc hydroxydopamine hydroxylase neurotoxin neurotrophic ohda oxidized phenylpyridinium radicals ros saved temporally toxins	abc accelerating acinar apical cd55 cd59 cofactor complement connection decay ductal exocrine exocrinopathy gland glands immunoblotting immunoperoxidase inflamed interstitial labial protectin protecting regulators saliva salivary sjogren sp ss surfaces
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