C3 and MASP1

Number of citations of the paper that reports this interaction (PMID 9719152)
17

Data Source:
HPRD (in vitro)

		C3	MASP1
Gene Name		complement component 3	mannan-binding lectin serine peptidase 1 (C4/C2 activating component of Ra-reactive factor)
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Gene Ontology Annotations	Cellular Component	Extracellular Region Extracellular Space Plasma Membrane Extracellular Vesicular Exosome Blood Microparticle	Extracellular Region Extracellular Space
	Molecular Function	Endopeptidase Inhibitor Activity Receptor Binding Protein Binding C5L2 Anaphylatoxin Chemotactic Receptor Binding	Serine-type Endopeptidase Activity Calcium Ion Binding Protein Binding Peptidase Activity Protein Homodimerization Activity Calcium-dependent Protein Binding
	Biological Process	Positive Regulation Of Type IIa Hypersensitivity Positive Regulation Of Protein Phosphorylation Positive Regulation Of Activation Of Membrane Attack Complex Fatty Acid Metabolic Process Inflammatory Response Immune Response Complement Activation Complement Activation, Alternative Pathway Complement Activation, Classical Pathway Signal Transduction G-protein Coupled Receptor Signaling Pathway Positive Regulation Vascular Endothelial Growth Factor Production Positive Regulation Of Glucose Transport Regulation Of Triglyceride Biosynthetic Process Positive Regulation Of Lipid Storage Negative Regulation Of Endopeptidase Activity Regulation Of Complement Activation Innate Immune Response Positive Regulation Of G-protein Coupled Receptor Protein Signaling Pathway Positive Regulation Of Angiogenesis Regulation Of Immune Response Positive Regulation Of Apoptotic Cell Clearance	Complement Activation, Lectin Pathway Proteolysis Receptor-mediated Endocytosis Complement Activation Innate Immune Response Negative Regulation Of Complement Activation
Pathways		Defective ACTH causes Obesity and Pro-opiomelanocortinin deficiency (POMCD) Signaling by GPCR Alternative complement activation Class A/1 (Rhodopsin-like receptors) Activation of C3 and C5 Metabolic disorders of biological oxidation enzymes GPCR ligand binding Initial triggering of complement GPCR downstream signaling Peptide ligand-binding receptors Regulation of Complement cascade Complement cascade G alpha (i) signalling events Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell Adaptive Immune System Innate Immune System	Creation of C4 and C2 activators Complement cascade Ficolins bind to repetitive carbohydrate structures on the target cell surface Scavenging by Class A Receptors Initial triggering of complement Lectin pathway of complement activation Innate Immune System
Drugs
Diseases
GWAS		Age-related macular degeneration ( 20385819 20385826 23455636 20861866 21665990) Age-related macular degeneration (CNV) ( 22705344) Age-related macular degeneration (GA) ( 22705344) Complement C3 and C4 levels ( 23028341)
Protein-Protein Interactions		27 interactors: ABL1 C2 C3AR1 C5 C5AR2 CD46 CFB CFH CFHR3 CFHR4 CFHR5 CFI CFP CPN1 CR1 CR2 CTSG GC ITGAM ITGAX LAMA1 LRP1 MASP1 OLFM4 PAPPA TGM2 VSIG4	15 interactors: C2 C3 FCN2 GADD45A GSK3B H2AFX MAPK6 MAPK8IP2 MBL2 NCK2 NUDT21 RPS6KA3 RPS6KA6 SERPING1 UFD1L
Entrez ID		718	5648
HPRD ID		00400	02749
Ensembl ID		ENSG00000125730	ENSG00000127241
Uniprot IDs		P01024	P48740
PDB IDs		1C3D 1GHQ 1W2S 2A73 2A74 2GOX 2HR0 2I07 2ICE 2ICF 2NOJ 2QKI 2WII 2WIN 2WY7 2WY8 2XQW 2XWB 2XWJ 3D5R 3D5S 3G6J 3L3O 3L5N 3NMS 3OED 3OHX 3OXU 3RJ3 3T4A 4HW5 4HWJ 4I6O 4M76	3DEM 3GOV 4AQB 4DJZ 4IGD 4IW4 4KKD
Enriched GO Terms of Interacting Partners?		Complement Activation Regulation Of Complement Activation Protein Activation Cascade Positive Regulation Of Immune Response Regulation Of Immune Response Regulation Of Humoral Immune Response Humoral Immune Response Regulation Of Immune System Process Defense Response Regulation Of Acute Inflammatory Response Positive Regulation Of Immune System Process Complement Activation, Alternative Pathway Regulation Of Inflammatory Response Innate Immune Response Immune Response Immune System Process Response To Stress Regulation Of Protein Processing Complement Activation, Classical Pathway Humoral Immune Response Mediated By Circulating Immunoglobulin Complement Receptor Mediated Signaling Pathway Leukocyte Mediated Immunity Response To Stimulus Immunoglobulin Mediated Immune Response B Cell Mediated Immunity Protein Metabolic Process Negative Regulation Of Immune System Process Adaptive Immune Response Based On Somatic Recombination Of Immune Receptors Built From Immunoglobulin Superfamily Domains Adaptive Immune Response Negative Regulation Of Complement Activation Regulation Of Protein Metabolic Process Response To External Stimulus Regulation Of Cytokine Production Negative Regulation Of Immune Response Negative Regulation Of Leukocyte Chemotaxis Chemotaxis Regulation Of Cell Adhesion Regulation Of Cell Motility Regulation Of Locomotion Regulation Of Cellular Component Movement Regulation Of Macrophage Chemotaxis Immune Response-regulating Signaling Pathway Proteolysis Leukocyte Migration Involved In Inflammatory Response Cell Surface Receptor Signaling Pathway Immune Response-activating Cell Surface Receptor Signaling Pathway Regulation Of Leukocyte Migration Cellular Calcium Ion Homeostasis Lymphocyte Proliferation Locomotion	Complement Activation Protein Activation Cascade Humoral Immune Response Innate Immune Response Regulation Of Immune System Process Regulation Of Immune Response Defense Response Response To Stress Positive Regulation Of Immune System Process Regulation Of Complement Activation Complement Activation, Classical Pathway Humoral Immune Response Mediated By Circulating Immunoglobulin Positive Regulation Of Immune Response Positive Regulation Of Phagocytosis Regulation Of Humoral Immune Response Immunoglobulin Mediated Immune Response B Cell Mediated Immunity Response To External Stimulus Negative Regulation Of Cellular Protein Metabolic Process Immune Response Regulation Of Phagocytosis Positive Regulation Of Apoptotic Cell Clearance Complement Activation, Lectin Pathway Negative Regulation Of Protein Metabolic Process Regulation Of Acute Inflammatory Response Adaptive Immune Response Based On Somatic Recombination Of Immune Receptors Built From Immunoglobulin Superfamily Domains Immune System Process Regulation Of Protein Metabolic Process Leukocyte Mediated Immunity Opsonization Regulation Of Apoptotic Cell Clearance Adaptive Immune Response Cell Morphogenesis Involved In Neuron Differentiation Neuron Projection Morphogenesis Signal Complex Assembly Positive Regulation Of Endocytosis Response To Stimulus Cell Morphogenesis Involved In Differentiation Axon Guidance Negative Regulation Of Catalytic Activity Regulation Of Phosphorylation Negative Regulation Of Phosphorylation Regulation Of Cellular Protein Metabolic Process Regulation Of Protein Processing Neuron Projection Development Cell Projection Morphogenesis Negative Regulation Of Cellular Metabolic Process Cell Part Morphogenesis Regulation Of Phosphorus Metabolic Process Cellular Response To Stress
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