C3 and CFHR3

Number of citations of the paper that reports this interaction (PMID 10622723)
15

Data Source:
BioGRID (pull down)
HPRD (in vitro)

		C3	CFHR3
Gene Name		complement component 3	complement factor H-related 3
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Extracellular Region Extracellular Space Plasma Membrane Extracellular Vesicular Exosome Blood Microparticle	Extracellular Space Extracellular Vesicular Exosome Blood Microparticle
	Molecular Function	Endopeptidase Inhibitor Activity Receptor Binding Protein Binding C5L2 Anaphylatoxin Chemotactic Receptor Binding
	Biological Process	Positive Regulation Of Type IIa Hypersensitivity Positive Regulation Of Protein Phosphorylation Positive Regulation Of Activation Of Membrane Attack Complex Fatty Acid Metabolic Process Inflammatory Response Immune Response Complement Activation Complement Activation, Alternative Pathway Complement Activation, Classical Pathway Signal Transduction G-protein Coupled Receptor Signaling Pathway Positive Regulation Vascular Endothelial Growth Factor Production Positive Regulation Of Glucose Transport Regulation Of Triglyceride Biosynthetic Process Positive Regulation Of Lipid Storage Negative Regulation Of Endopeptidase Activity Regulation Of Complement Activation Innate Immune Response Positive Regulation Of G-protein Coupled Receptor Protein Signaling Pathway Positive Regulation Of Angiogenesis Regulation Of Immune Response Positive Regulation Of Apoptotic Cell Clearance
Pathways		Defective ACTH causes Obesity and Pro-opiomelanocortinin deficiency (POMCD) Signaling by GPCR Alternative complement activation Class A/1 (Rhodopsin-like receptors) Activation of C3 and C5 Metabolic disorders of biological oxidation enzymes GPCR ligand binding Initial triggering of complement GPCR downstream signaling Peptide ligand-binding receptors Regulation of Complement cascade Complement cascade G alpha (i) signalling events Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell Adaptive Immune System Innate Immune System	Regulation of Complement cascade Complement cascade Innate Immune System
Drugs
Diseases
GWAS		Age-related macular degeneration ( 20385819 20385826 23455636 20861866 21665990) Age-related macular degeneration (CNV) ( 22705344) Age-related macular degeneration (GA) ( 22705344) Complement C3 and C4 levels ( 23028341)	Age-related macular degeneration ( 23536807) Complement C3 and C4 levels ( 23028341) Meningococcal disease ( 20694013) Nephropathy ( 21399633)
Protein-Protein Interactions		27 interactors: ABL1 C2 C3AR1 C5 C5AR2 CD46 CFB CFH CFHR3 CFHR4 CFHR5 CFI CFP CPN1 CR1 CR2 CTSG GC ITGAM ITGAX LAMA1 LRP1 MASP1 OLFM4 PAPPA TGM2 VSIG4	2 interactors: C3 PRDX4
Entrez ID		718	10878
HPRD ID		00400	05626
Ensembl ID		ENSG00000125730	ENSG00000116785
Uniprot IDs		P01024	Q02985 Q6NSD3
PDB IDs		1C3D 1GHQ 1W2S 2A73 2A74 2GOX 2HR0 2I07 2ICE 2ICF 2NOJ 2QKI 2WII 2WIN 2WY7 2WY8 2XQW 2XWB 2XWJ 3D5R 3D5S 3G6J 3L3O 3L5N 3NMS 3OED 3OHX 3OXU 3RJ3 3T4A 4HW5 4HWJ 4I6O 4M76
Enriched GO Terms of Interacting Partners?		Complement Activation Regulation Of Complement Activation Protein Activation Cascade Positive Regulation Of Immune Response Regulation Of Immune Response Regulation Of Humoral Immune Response Humoral Immune Response Regulation Of Immune System Process Defense Response Regulation Of Acute Inflammatory Response Positive Regulation Of Immune System Process Complement Activation, Alternative Pathway Regulation Of Inflammatory Response Innate Immune Response Immune Response Immune System Process Response To Stress Regulation Of Protein Processing Complement Activation, Classical Pathway Humoral Immune Response Mediated By Circulating Immunoglobulin Complement Receptor Mediated Signaling Pathway Leukocyte Mediated Immunity Response To Stimulus Immunoglobulin Mediated Immune Response B Cell Mediated Immunity Protein Metabolic Process Negative Regulation Of Immune System Process Adaptive Immune Response Based On Somatic Recombination Of Immune Receptors Built From Immunoglobulin Superfamily Domains Adaptive Immune Response Negative Regulation Of Complement Activation Regulation Of Protein Metabolic Process Response To External Stimulus Regulation Of Cytokine Production Negative Regulation Of Immune Response Negative Regulation Of Leukocyte Chemotaxis Chemotaxis Regulation Of Cell Adhesion Regulation Of Cell Motility Regulation Of Locomotion Regulation Of Cellular Component Movement Regulation Of Macrophage Chemotaxis Immune Response-regulating Signaling Pathway Proteolysis Leukocyte Migration Involved In Inflammatory Response Cell Surface Receptor Signaling Pathway Immune Response-activating Cell Surface Receptor Signaling Pathway Regulation Of Leukocyte Migration Cellular Calcium Ion Homeostasis Lymphocyte Proliferation Locomotion	Negative Regulation Of Male Germ Cell Proliferation Positive Regulation Of Type IIa Hypersensitivity Regulation Of Male Germ Cell Proliferation Positive Regulation Of Activation Of Membrane Attack Complex Positive Regulation Of Hypersensitivity Monocarboxylic Acid Metabolic Process Positive Regulation Of Apoptotic Cell Clearance Positive Regulation Of Acute Inflammatory Response To Antigenic Stimulus Protein Maturation By Protein Folding Regulation Of Apoptotic Cell Clearance Complement Activation, Alternative Pathway Positive Regulation Of Inflammatory Response To Antigenic Stimulus I-kappaB Phosphorylation Positive Regulation Of Humoral Immune Response Positive Regulation Of G-protein Coupled Receptor Protein Signaling Pathway Positive Regulation Of Protein Processing Regulation Of Triglyceride Biosynthetic Process 4-hydroxyproline Metabolic Process Carboxylic Acid Metabolic Process Positive Regulation Of Acute Inflammatory Response Organic Acid Metabolic Process Regulation Of Complement Activation Positive Regulation Vascular Endothelial Growth Factor Production Positive Regulation Of Lipid Storage Regulation Of Triglyceride Metabolic Process Positive Regulation Of Immunoglobulin Mediated Immune Response Protein Maturation Regulation Of Vascular Endothelial Growth Factor Production Positive Regulation Of Phagocytosis Positive Regulation Of Glucose Transport Regulation Of Humoral Immune Response I-kappaB Kinase/NF-kappaB Signaling Regulation Of Lipid Storage Regulation Of Phagocytosis Regulation Of Acute Inflammatory Response Positive Regulation Of Inflammatory Response Regulation Of Glucose Transport Positive Regulation Of Endocytosis Reactive Oxygen Species Metabolic Process Small Molecule Metabolic Process Cell Redox Homeostasis Positive Regulation Of Angiogenesis Complement Activation, Classical Pathway Regulation Of Lipid Biosynthetic Process Humoral Immune Response Mediated By Circulating Immunoglobulin Complement Activation Positive Regulation Of Adaptive Immune Response Male Gonad Development Protein Activation Cascade Regulation Of G-protein Coupled Receptor Protein Signaling Pathway
Tagcloud ?		accordance antioxidants asp assignment boc buckminsterfullerene c60 carboxyfullerene carboxyfullerenes collapse dopaminergic dugan dyes entirely fluoromethylketone fluorophores hoc hydroxydopamine hydroxylase neurotoxin neurotrophic ohda oxidized phenylpyridinium radicals ros saved temporally toxins	acquiring arguing attachment c3 c5 cfhr1 cfhr2 cfhr4a complement convertase evade expense fba fhl hemolytic heparin m28 m55 m6 scl1 scl2 scr18 scr3 scr7 serotypes streptococcal streptococci uremic utilize
Tagcloud (Difference) ?		accordance antioxidants asp assignment boc buckminsterfullerene c60 carboxyfullerene carboxyfullerenes collapse dopaminergic dugan dyes entirely fluoromethylketone fluorophores hoc hydroxydopamine hydroxylase neurotoxin neurotrophic ohda oxidized phenylpyridinium radicals ros saved temporally toxins	acquiring arguing attachment c5 cfhr1 cfhr2 cfhr4a complement convertase evade expense fba fhl hemolytic heparin m28 m55 m6 scl1 scl2 scr18 scr3 scr7 serotypes streptococcal streptococci uremic utilize
Tagcloud (Intersection) ?		c3