TLR1 and TLR10

Number of citations of the paper that reports this interaction (PMID 15728506)
62

Data Source:
HPRD (in vivo)

		TLR1	TLR10
Gene Name		toll-like receptor 1	toll-like receptor 10
Image
Gene Ontology Annotations	Cellular Component	Plasma Membrane Integral Component Of Plasma Membrane Membrane Phagocytic Vesicle Membrane Toll-like Receptor 1-Toll-like Receptor 2 Protein Complex	Plasma Membrane Membrane Integral Component Of Membrane
	Molecular Function	Receptor Activity Transmembrane Signaling Receptor Activity Protein Heterodimerization Activity	Transmembrane Signaling Receptor Activity
	Biological Process	MyD88-dependent Toll-like Receptor Signaling Pathway Inflammatory Response Immune Response Signal Transduction Toll-like Receptor 1 Signaling Pathway Macrophage Activation Detection Of Triacyl Bacterial Lipopeptide Positive Regulation Of Tumor Necrosis Factor Biosynthetic Process Innate Immune Response Positive Regulation Of Interleukin-6 Biosynthetic Process Regulation Of Cytokine Secretion Cellular Response To Triacyl Bacterial Lipopeptide	Toll-like Receptor Signaling Pathway MyD88-dependent Toll-like Receptor Signaling Pathway Inflammatory Response Immune Response Toll-like Receptor 5 Signaling Pathway Toll-like Receptor 10 Signaling Pathway Innate Immune Response Regulation Of Cytokine Secretion Positive Regulation Of Inflammatory Response
Pathways			Toll-Like Receptors Cascades Toll Like Receptor 10 (TLR10) Cascade MyD88 cascade initiated on plasma membrane Toll Like Receptor 5 (TLR5) Cascade Innate Immune System
Drugs
Diseases
GWAS		Alcohol consumption ( 23743675) Helicobacter pylori serologic status ( 23652523)	Helicobacter pylori serologic status ( 23652523)
Protein-Protein Interactions		9 interactors: DHX36 HSP90B1 HSPD1 TLR10 TLR2 TLR4 TLR5 TLR9 TRAP1	11 interactors: CAT ECH1 F8A1 FLNA FUT7 GLDC LUC7L3 MYD88 PTPN6 TLR1 TLR2
Entrez ID		7096	81793
HPRD ID		03119	05884
Ensembl ID		ENSG00000174125	ENSG00000174123
Uniprot IDs		Q15399 Q32MK4	Q9BXR5
PDB IDs		1FYV 2Z7X	2J67
Enriched GO Terms of Interacting Partners?		Toll-like Receptor Signaling Pathway Pattern Recognition Receptor Signaling Pathway Innate Immune Response-activating Signal Transduction Activation Of Innate Immune Response MyD88-dependent Toll-like Receptor Signaling Pathway Positive Regulation Of Innate Immune Response Regulation Of Innate Immune Response Positive Regulation Of Type I Interferon Production Immune Response-regulating Signaling Pathway Regulation Of Cytokine Production Regulation Of Type I Interferon Production Positive Regulation Of Interleukin-10 Production Positive Regulation Of Interleukin-8 Production Positive Regulation Of Immune Response Regulation Of Cytokine Secretion Immune Response Positive Regulation Of Cytokine Production Positive Regulation Of Interleukin-12 Production Innate Immune Response Regulation Of Immune Response Positive Regulation Of Immune System Process Regulation Of Reactive Oxygen Species Biosynthetic Process Regulation Of Interleukin-12 Production Positive Regulation Of Interleukin-6 Production Positive Regulation Of Toll-like Receptor Signaling Pathway Positive Regulation Of Nitric-oxide Synthase Biosynthetic Process I-kappaB Phosphorylation Positive Regulation Of Inflammatory Response Positive Regulation Of Interferon-alpha Production Response To Stress Immune System Process Regulation Of Interleukin-6 Production Regulation Of Immune System Process Positive Regulation Of NF-kappaB Import Into Nucleus Defense Response Positive Regulation Of Interferon-beta Production Regulation Of Protein Secretion Regulation Of Reactive Oxygen Species Metabolic Process Inflammatory Response Positive Regulation Of Interleukin-18 Production Positive Regulation Of Transcription Factor Import Into Nucleus Regulation Of Interferon-beta Production Positive Regulation Of Nitric Oxide Biosynthetic Process Regulation Of Toll-like Receptor Signaling Pathway Regulation Of NF-kappaB Import Into Nucleus Positive Regulation Of Reactive Oxygen Species Biosynthetic Process Positive Regulation Of Chemokine Production Defense Response To Bacterium Positive Regulation Of Interferon-gamma Production Regulation Of Chemokine Production	Cellular Response To Triacyl Bacterial Lipopeptide Detection Of Triacyl Bacterial Lipopeptide Response To Molecule Of Fungal Origin Positive Regulation Of Tumor Necrosis Factor Production Positive Regulation Of Interleukin-6 Production Positive Regulation Of Cytokine Biosynthetic Process Regulation Of Innate Immune Response Detection Of Bacterial Lipoprotein MyD88-dependent Toll-like Receptor Signaling Pathway Cell Activation Regulation Of Tumor Necrosis Factor Production Positive Regulation Of Tumor Necrosis Factor Biosynthetic Process Cellular Response To Bacterial Lipopeptide Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Regulation Of Interleukin-6 Production Response To Peptidoglycan Detection Of Molecule Of Bacterial Origin Toll-like Receptor Signaling Pathway Regulation Of Cytokine Biosynthetic Process Positive Regulation Of Intracellular Signal Transduction Positive Regulation Of NF-kappaB Transcription Factor Activity Regulation Of Tumor Necrosis Factor Biosynthetic Process Pattern Recognition Receptor Signaling Pathway Innate Immune Response-activating Signal Transduction Activation Of Innate Immune Response Detection Of Bacterium Immune Response-regulating Signaling Pathway Cellular Response To Molecule Of Bacterial Origin Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling Negative Regulation Of Growth Of Symbiont In Host Positive Regulation Of Innate Immune Response Detection Of Biotic Stimulus Macrophage Activation Positive Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Glycine Metabolic Process Regulation Of I-kappaB Kinase/NF-kappaB Signaling Platelet Aggregation Positive Regulation Of Immune Response Positive Regulation Of Signal Transduction Positive Regulation Of Transcription Factor Import Into Nucleus Lipopolysaccharide-mediated Signaling Pathway Response To Fungus Immune Response Positive Regulation Of Chemokine Production Regulation Of Chemokine Production Serine Family Amino Acid Metabolic Process Toll-like Receptor TLR6:TLR2 Signaling Pathway Toll-like Receptor TLR1:TLR2 Signaling Pathway Toll-like Receptor 2 Signaling Pathway Innate Immune Response
Tagcloud ?		bed cd14 constitutively fibroblast immunoassay immunocytochemistry lamina lipopolysaccharide lps md measuring microorganisms nucleus p65 polyp propria quantified respond responsiveness scar strategic supernatant tlr4 tlr9 tlrs toll vff vffs vocal	bewo broadly danger endosomal immunoassay initiating inter multiplex placental proper qpcr respond ten tlr2 tlr3 tlr4 tlr5 tlr6 tlr7 tlr8 tlr9 tlrs toll trimester trophoblast trophoblasts vegfa
Tagcloud (Difference) ?		bed cd14 constitutively fibroblast immunocytochemistry lamina lipopolysaccharide lps md measuring microorganisms nucleus p65 polyp propria quantified responsiveness scar strategic supernatant vff vffs vocal	bewo broadly danger endosomal initiating inter multiplex placental proper qpcr ten tlr2 tlr3 tlr5 tlr6 tlr7 tlr8 trimester trophoblast trophoblasts vegfa
Tagcloud (Intersection) ?		immunoassay respond tlr4 tlr9 tlrs toll