TLR1

Gene Name		toll-like receptor 1
Image
Gene Ontology Annotations	Cellular Component	Plasma Membrane Integral Component Of Plasma Membrane Membrane Phagocytic Vesicle Membrane Toll-like Receptor 1-Toll-like Receptor 2 Protein Complex
	Molecular Function	Receptor Activity Transmembrane Signaling Receptor Activity Protein Heterodimerization Activity
	Biological Process	MyD88-dependent Toll-like Receptor Signaling Pathway Inflammatory Response Immune Response Signal Transduction Toll-like Receptor 1 Signaling Pathway Macrophage Activation Detection Of Triacyl Bacterial Lipopeptide Positive Regulation Of Tumor Necrosis Factor Biosynthetic Process Innate Immune Response Positive Regulation Of Interleukin-6 Biosynthetic Process Regulation Of Cytokine Secretion Cellular Response To Triacyl Bacterial Lipopeptide
Pathways
Drugs
Diseases
GWAS		Alcohol consumption ( 23743675) Helicobacter pylori serologic status ( 23652523)
Protein-protein Interactions		9 interactors: DHX36 HSP90B1 HSPD1 TLR10 TLR2 TLR4 TLR5 TLR9 TRAP1
Entrez ID		7096
HPRD ID		03119
Ensembl ID		ENSG00000174125
Uniprot IDs		Q15399 Q32MK4
PDB IDs		1FYV 2Z7X
Enriched GO Terms of Interacting Partners?		Toll-like Receptor Signaling Pathway Pattern Recognition Receptor Signaling Pathway Innate Immune Response-activating Signal Transduction Activation Of Innate Immune Response MyD88-dependent Toll-like Receptor Signaling Pathway Positive Regulation Of Innate Immune Response Regulation Of Innate Immune Response Positive Regulation Of Type I Interferon Production Immune Response-regulating Signaling Pathway Regulation Of Cytokine Production Regulation Of Type I Interferon Production Positive Regulation Of Interleukin-10 Production Positive Regulation Of Interleukin-8 Production Positive Regulation Of Immune Response Regulation Of Cytokine Secretion Immune Response Positive Regulation Of Cytokine Production Positive Regulation Of Interleukin-12 Production Innate Immune Response Regulation Of Immune Response Positive Regulation Of Immune System Process Regulation Of Reactive Oxygen Species Biosynthetic Process Regulation Of Interleukin-12 Production Positive Regulation Of Interleukin-6 Production Positive Regulation Of Toll-like Receptor Signaling Pathway Positive Regulation Of Nitric-oxide Synthase Biosynthetic Process I-kappaB Phosphorylation Positive Regulation Of Inflammatory Response Positive Regulation Of Interferon-alpha Production Response To Stress Immune System Process Regulation Of Interleukin-6 Production Regulation Of Immune System Process Positive Regulation Of NF-kappaB Import Into Nucleus Defense Response Positive Regulation Of Interferon-beta Production Regulation Of Protein Secretion Regulation Of Reactive Oxygen Species Metabolic Process Inflammatory Response Positive Regulation Of Interleukin-18 Production Positive Regulation Of Transcription Factor Import Into Nucleus Regulation Of Interferon-beta Production Positive Regulation Of Nitric Oxide Biosynthetic Process Regulation Of Toll-like Receptor Signaling Pathway Regulation Of NF-kappaB Import Into Nucleus Positive Regulation Of Reactive Oxygen Species Biosynthetic Process Positive Regulation Of Chemokine Production Defense Response To Bacterium Positive Regulation Of Interferon-gamma Production Regulation Of Chemokine Production
Tagcloud ?		bed cd14 constitutively fibroblast immunoassay immunocytochemistry lamina lipopolysaccharide lps md measuring microorganisms nucleus p65 polyp propria quantified respond responsiveness scar strategic supernatant tlr4 tlr9 tlrs toll vff vffs vocal