TLR1 and TLR5

Number of citations of the paper that reports this interaction (PMID 12600829)
11

Data Source:
HPRD (in vitro)

		TLR1	TLR5
Gene Name		toll-like receptor 1	toll-like receptor 5
Image
Gene Ontology Annotations	Cellular Component	Plasma Membrane Integral Component Of Plasma Membrane Membrane Phagocytic Vesicle Membrane Toll-like Receptor 1-Toll-like Receptor 2 Protein Complex	Plasma Membrane Integral Component Of Membrane
	Molecular Function	Receptor Activity Transmembrane Signaling Receptor Activity Protein Heterodimerization Activity	Transmembrane Signaling Receptor Activity Interleukin-1 Receptor Binding
	Biological Process	MyD88-dependent Toll-like Receptor Signaling Pathway Inflammatory Response Immune Response Signal Transduction Toll-like Receptor 1 Signaling Pathway Macrophage Activation Detection Of Triacyl Bacterial Lipopeptide Positive Regulation Of Tumor Necrosis Factor Biosynthetic Process Innate Immune Response Positive Regulation Of Interleukin-6 Biosynthetic Process Regulation Of Cytokine Secretion Cellular Response To Triacyl Bacterial Lipopeptide	Toll-like Receptor Signaling Pathway MyD88-dependent Toll-like Receptor Signaling Pathway Inflammatory Response Male Gonad Development Positive Regulation Of Interleukin-8 Production Positive Regulation Of Toll-like Receptor Signaling Pathway Toll-like Receptor 5 Signaling Pathway Toll-like Receptor 10 Signaling Pathway Defense Response To Bacterium Innate Immune Response Positive Regulation Of Nitric Oxide Biosynthetic Process Regulation Of Cytokine Secretion Cellular Response To Lipopolysaccharide Cellular Response To Mechanical Stimulus
Pathways			Toll-Like Receptors Cascades Toll Like Receptor 10 (TLR10) Cascade MyD88 cascade initiated on plasma membrane Toll Like Receptor 5 (TLR5) Cascade Innate Immune System
Drugs
Diseases
GWAS		Alcohol consumption ( 23743675) Helicobacter pylori serologic status ( 23652523)
Protein-Protein Interactions		9 interactors: DHX36 HSP90B1 HSPD1 TLR10 TLR2 TLR4 TLR5 TLR9 TRAP1	5 interactors: MYD88 RNF216 SIGIRR TLR1 TLR4
Entrez ID		7096	7100
HPRD ID		03119	04326
Ensembl ID		ENSG00000174125	ENSG00000187554
Uniprot IDs		Q15399 Q32MK4	O60602
PDB IDs		1FYV 2Z7X	1P95 3J0A
Enriched GO Terms of Interacting Partners?		Toll-like Receptor Signaling Pathway Pattern Recognition Receptor Signaling Pathway Innate Immune Response-activating Signal Transduction Activation Of Innate Immune Response MyD88-dependent Toll-like Receptor Signaling Pathway Positive Regulation Of Innate Immune Response Regulation Of Innate Immune Response Positive Regulation Of Type I Interferon Production Immune Response-regulating Signaling Pathway Regulation Of Cytokine Production Regulation Of Type I Interferon Production Positive Regulation Of Interleukin-10 Production Positive Regulation Of Interleukin-8 Production Positive Regulation Of Immune Response Regulation Of Cytokine Secretion Immune Response Positive Regulation Of Cytokine Production Positive Regulation Of Interleukin-12 Production Innate Immune Response Regulation Of Immune Response Positive Regulation Of Immune System Process Regulation Of Reactive Oxygen Species Biosynthetic Process Regulation Of Interleukin-12 Production Positive Regulation Of Interleukin-6 Production Positive Regulation Of Toll-like Receptor Signaling Pathway Positive Regulation Of Nitric-oxide Synthase Biosynthetic Process I-kappaB Phosphorylation Positive Regulation Of Inflammatory Response Positive Regulation Of Interferon-alpha Production Response To Stress Immune System Process Regulation Of Interleukin-6 Production Regulation Of Immune System Process Positive Regulation Of NF-kappaB Import Into Nucleus Defense Response Positive Regulation Of Interferon-beta Production Regulation Of Protein Secretion Regulation Of Reactive Oxygen Species Metabolic Process Inflammatory Response Positive Regulation Of Interleukin-18 Production Positive Regulation Of Transcription Factor Import Into Nucleus Regulation Of Interferon-beta Production Positive Regulation Of Nitric Oxide Biosynthetic Process Regulation Of Toll-like Receptor Signaling Pathway Regulation Of NF-kappaB Import Into Nucleus Positive Regulation Of Reactive Oxygen Species Biosynthetic Process Positive Regulation Of Chemokine Production Defense Response To Bacterium Positive Regulation Of Interferon-gamma Production Regulation Of Chemokine Production	Regulation Of Cytokine Biosynthetic Process Regulation Of Cytokine Production Positive Regulation Of Tumor Necrosis Factor Production Regulation Of Chemokine Production Positive Regulation Of Interleukin-6 Production Positive Regulation Of Cytokine Biosynthetic Process MyD88-dependent Toll-like Receptor Signaling Pathway Inflammatory Response Regulation Of Tumor Necrosis Factor Production Regulation Of Interleukin-6 Production Toll-like Receptor Signaling Pathway Regulation Of Type I Interferon Production Pattern Recognition Receptor Signaling Pathway Innate Immune Response-activating Signal Transduction Positive Regulation Of Tumor Necrosis Factor Biosynthetic Process Activation Of Innate Immune Response Detection Of Molecule Of Bacterial Origin Cellular Response To Molecule Of Bacterial Origin Regulation Of Tumor Necrosis Factor Biosynthetic Process Positive Regulation Of Innate Immune Response Regulation Of Innate Immune Response Detection Of Biotic Stimulus Macrophage Activation Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Lipopolysaccharide-mediated Signaling Pathway Response To Molecule Of Bacterial Origin Response To Fungus Regulation Of Interferon-beta Production Positive Regulation Of Chemokine Production Positive Regulation Of Cytokine Production Regulation Of Immune System Process Defense Response Toll-like Receptor TLR6:TLR2 Signaling Pathway Toll-like Receptor TLR1:TLR2 Signaling Pathway Toll-like Receptor 2 Signaling Pathway Immune Response-regulating Signaling Pathway Response To Bacterium Cellular Response To Mechanical Stimulus Positive Regulation Of Type I Interferon Production Toll-like Receptor 4 Signaling Pathway Positive Regulation Of Immune Response Toll-like Receptor 1 Signaling Pathway Positive Regulation Of Nucleotide-binding Oligomerization Domain Containing 1 Signaling Pathway Detection Of Fungus Positive Regulation Of Lymphocyte Proliferation Positive Regulation Of Mononuclear Cell Proliferation Response To Other Organism Positive Regulation Of JNK Cascade Positive Regulation Of NF-kappaB Transcription Factor Activity Response To Biotic Stimulus
Tagcloud ?		bed cd14 constitutively fibroblast immunoassay immunocytochemistry lamina lipopolysaccharide lps md measuring microorganisms nucleus p65 polyp propria quantified respond responsiveness scar strategic supernatant tlr4 tlr9 tlrs toll vff vffs vocal	adjuvanted alum anticocaine antihapten avenue benchmark boosting c4 cocaine conjugates exploration flagellin flic gne hampered hapten immunogenicity impacting inadequate indirectly klh liposomal lives millions mpla nlrc4 problematic reasoning tactics
Tagcloud (Difference) ?		bed cd14 constitutively fibroblast immunoassay immunocytochemistry lamina lipopolysaccharide lps md measuring microorganisms nucleus p65 polyp propria quantified respond responsiveness scar strategic supernatant tlr4 tlr9 tlrs toll vff vffs vocal	adjuvanted alum anticocaine antihapten avenue benchmark boosting c4 cocaine conjugates exploration flagellin flic gne hampered hapten immunogenicity impacting inadequate indirectly klh liposomal lives millions mpla nlrc4 problematic reasoning tactics
Tagcloud (Intersection) ?