TLR1 and TRAP1

Number of citations of the paper that reports this interaction (PMID 16482509)
13

Data Source:
HPRD (two hybrid)

		TLR1	TRAP1
Gene Name		toll-like receptor 1	TNF receptor-associated protein 1
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Plasma Membrane Integral Component Of Plasma Membrane Membrane Phagocytic Vesicle Membrane Toll-like Receptor 1-Toll-like Receptor 2 Protein Complex	Nucleoplasm Mitochondrion Mitochondrial Inner Membrane Mitochondrial Intermembrane Space Mitochondrial Matrix Lipid Particle Membrane Extracellular Vesicular Exosome
	Molecular Function	Receptor Activity Transmembrane Signaling Receptor Activity Protein Heterodimerization Activity	Tumor Necrosis Factor Receptor Binding Protein Binding ATP Binding Protein Kinase Binding Poly(A) RNA Binding Unfolded Protein Binding
	Biological Process	MyD88-dependent Toll-like Receptor Signaling Pathway Inflammatory Response Immune Response Signal Transduction Toll-like Receptor 1 Signaling Pathway Macrophage Activation Detection Of Triacyl Bacterial Lipopeptide Positive Regulation Of Tumor Necrosis Factor Biosynthetic Process Innate Immune Response Positive Regulation Of Interleukin-6 Biosynthetic Process Regulation Of Cytokine Secretion Cellular Response To Triacyl Bacterial Lipopeptide	Response To Stress Chaperone-mediated Protein Folding Negative Regulation Of Cellular Respiration Negative Regulation Of Oxidative Stress-induced Intrinsic Apoptotic Signaling Pathway Negative Regulation Of Reactive Oxygen Species Biosynthetic Process
Pathways
Drugs
Diseases
GWAS		Alcohol consumption ( 23743675) Helicobacter pylori serologic status ( 23652523)	Metabolite levels (HVA/5-HIAA ratio) ( 23319000)
Protein-Protein Interactions		9 interactors: DHX36 HSP90B1 HSPD1 TLR10 TLR2 TLR4 TLR5 TLR9 TRAP1	14 interactors: APP ESX1 EXT1 EXT2 HGS PSMC4 RB1 SMAD4 TGFBR1 TGFBR2 TLR1 TLR6 TNFRSF1A TPM3
Entrez ID		7096	10131
HPRD ID		03119	05868
Ensembl ID		ENSG00000174125	ENSG00000126602
Uniprot IDs		Q15399 Q32MK4	B4DR68 F5H897 Q12931 Q53FS6
PDB IDs		1FYV 2Z7X
Enriched GO Terms of Interacting Partners?		Toll-like Receptor Signaling Pathway Pattern Recognition Receptor Signaling Pathway Innate Immune Response-activating Signal Transduction Activation Of Innate Immune Response MyD88-dependent Toll-like Receptor Signaling Pathway Positive Regulation Of Innate Immune Response Regulation Of Innate Immune Response Positive Regulation Of Type I Interferon Production Immune Response-regulating Signaling Pathway Regulation Of Cytokine Production Regulation Of Type I Interferon Production Positive Regulation Of Interleukin-10 Production Positive Regulation Of Interleukin-8 Production Positive Regulation Of Immune Response Regulation Of Cytokine Secretion Immune Response Positive Regulation Of Cytokine Production Positive Regulation Of Interleukin-12 Production Innate Immune Response Regulation Of Immune Response Positive Regulation Of Immune System Process Regulation Of Reactive Oxygen Species Biosynthetic Process Regulation Of Interleukin-12 Production Positive Regulation Of Interleukin-6 Production Positive Regulation Of Toll-like Receptor Signaling Pathway Positive Regulation Of Nitric-oxide Synthase Biosynthetic Process I-kappaB Phosphorylation Positive Regulation Of Inflammatory Response Positive Regulation Of Interferon-alpha Production Response To Stress Immune System Process Regulation Of Interleukin-6 Production Regulation Of Immune System Process Positive Regulation Of NF-kappaB Import Into Nucleus Defense Response Positive Regulation Of Interferon-beta Production Regulation Of Protein Secretion Regulation Of Reactive Oxygen Species Metabolic Process Inflammatory Response Positive Regulation Of Interleukin-18 Production Positive Regulation Of Transcription Factor Import Into Nucleus Regulation Of Interferon-beta Production Positive Regulation Of Nitric Oxide Biosynthetic Process Regulation Of Toll-like Receptor Signaling Pathway Regulation Of NF-kappaB Import Into Nucleus Positive Regulation Of Reactive Oxygen Species Biosynthetic Process Positive Regulation Of Chemokine Production Defense Response To Bacterium Positive Regulation Of Interferon-gamma Production Regulation Of Chemokine Production	Positive Regulation Of Protein Metabolic Process Regulation Of Protein Metabolic Process Positive Regulation Of Cellular Protein Metabolic Process Regulation Of Cellular Localization Signal Transduction Embryonic Morphogenesis Regulation Of Protein Phosphorylation Heparan Sulfate Proteoglycan Biosynthetic Process, Polysaccharide Chain Biosynthetic Process Embryo Development Signaling Positive Regulation Of Metabolic Process Cell Communication Positive Regulation Of Cellular Metabolic Process Detection Of Bacterial Lipoprotein Chordate Embryonic Development Regulation Of Protein Localization Embryo Development Ending In Birth Or Egg Hatching Gastrulation Regulation Of Phosphorylation Regulation Of Cellular Protein Metabolic Process Regulation Of Signal Transduction Positive Regulation Of Protein Modification Process In Utero Embryonic Development Endothelial Cell Activation Regulation Of Phosphorus Metabolic Process Positive Regulation Of Macromolecule Biosynthetic Process Apoptotic Process Cellular Response To Stimulus Regulation Of Signaling Positive Regulation Of Interleukin-6 Biosynthetic Process Programmed Cell Death Positive Regulation Of Cellular Biosynthetic Process Positive Regulation Of SMAD Protein Import Into Nucleus Cell Death Death Detection Of Molecule Of Bacterial Origin Cellular Response To Bacterial Lipopeptide Regulation Of Protein Transport Anatomical Structure Morphogenesis Positive Regulation Of Protein Import Into Nucleus Regulation Of SMAD Protein Import Into Nucleus Regulation Of Interleukin-6 Production Pathway-restricted SMAD Protein Phosphorylation Regulation Of Establishment Of Protein Localization Negative Regulation Of Cell Proliferation Palate Development Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Cell Activation Positive Regulation Of Protein Localization To Nucleus Positive Regulation Of Nucleocytoplasmic Transport
Tagcloud ?		bed cd14 constitutively fibroblast immunoassay immunocytochemistry lamina lipopolysaccharide lps md measuring microorganisms nucleus p65 polyp propria quantified respond responsiveness scar strategic supernatant tlr4 tlr9 tlrs toll vff vffs vocal	apg1 forelimb forelimbs grp94 hindlimb hindlimbs hsp10 hsp105 hsp110 hsp20 hsp22 hsp25 hsp47 hsp60 hspa12a hspa12b hspa13 hspa14 hspa1l hspb10 hspb2 hspb3 hspb4 hspb7 hspb9 hsps oligodactylic performs phocomelic
Tagcloud (Difference) ?		bed cd14 constitutively fibroblast immunoassay immunocytochemistry lamina lipopolysaccharide lps md measuring microorganisms nucleus p65 polyp propria quantified respond responsiveness scar strategic supernatant tlr4 tlr9 tlrs toll vff vffs vocal	apg1 forelimb forelimbs grp94 hindlimb hindlimbs hsp10 hsp105 hsp110 hsp20 hsp22 hsp25 hsp47 hsp60 hspa12a hspa12b hspa13 hspa14 hspa1l hspb10 hspb2 hspb3 hspb4 hspb7 hspb9 hsps oligodactylic performs phocomelic
Tagcloud (Intersection) ?