TF and IGF1

Number of citations of the paper that reports this interaction (PMID 11749962)
5

Data Source:
BioGRID (pull down)

		TF	IGF1
Gene Name		transferrin	insulin-like growth factor 1 (somatomedin C)
Image
Gene Ontology Annotations	Cellular Component	Extracellular Region Extracellular Space Early Endosome Late Endosome Coated Pit Basal Plasma Membrane Cell Surface Endosome Membrane Cytoplasmic Membrane-bounded Vesicle Apical Plasma Membrane Endocytic Vesicle Vesicle Secretory Granule Lumen Basal Part Of Cell Perinuclear Region Of Cytoplasm Recycling Endosome Extracellular Vesicular Exosome Blood Microparticle	Extracellular Region Extracellular Space Plasma Membrane Insulin-like Growth Factor Binding Protein Complex Platelet Alpha Granule Lumen
	Molecular Function	Protein Binding Ferric Iron Binding Ubiquitin Protein Ligase Binding	Insulin Receptor Binding Insulin-like Growth Factor Receptor Binding Integrin Binding Hormone Activity Protein Binding Growth Factor Activity
	Biological Process	Retina Homeostasis Platelet Degranulation Cellular Iron Ion Homeostasis Blood Coagulation Platelet Activation Transferrin Transport Transmembrane Transport	Skeletal System Development Cell Activation Blood Vessel Remodeling Platelet Degranulation DNA Replication Movement Of Cell Or Subcellular Component Signal Transduction Ras Protein Signal Transduction Muscle Organ Development Blood Coagulation Positive Regulation Of Cell Proliferation Negative Regulation Of Cell Proliferation Response To Heat Glycolate Metabolic Process Glial Cell Differentiation Regulation Of Gene Expression Positive Regulation Of Cardiac Muscle Hypertrophy Positive Regulation Of Phosphatidylinositol 3-kinase Signaling Skeletal Muscle Satellite Cell Maintenance Involved In Skeletal Muscle Regeneration Muscle Hypertrophy Myotube Cell Development Positive Regulation Of Smooth Muscle Cell Migration Positive Regulation Of Cerebellar Granule Cell Precursor Proliferation Water Homeostasis Proteoglycan Biosynthetic Process Platelet Activation Mammary Gland Development Exocrine Pancreas Development Regulation Of Establishment Or Maintenance Of Cell Polarity Positive Regulation Of Protein Import Into Nucleus, Translocation Negative Regulation Of Smooth Muscle Cell Apoptotic Process Multicellular Organism Growth Bone Mineralization Involved In Bone Maturation Regulation Of Multicellular Organism Growth Positive Regulation Of Activated T Cell Proliferation Positive Regulation Of Tyrosine Phosphorylation Of Stat5 Protein Negative Regulation Of Apoptotic Process Positive Regulation Of DNA Binding Positive Regulation Of MAPK Cascade Positive Regulation Of Insulin-like Growth Factor Receptor Signaling Pathway Cellular Protein Metabolic Process Myoblast Differentiation Positive Regulation Of Osteoblast Differentiation Positive Regulation Of Glycogen Biosynthetic Process Positive Regulation Of DNA Replication Positive Regulation Of Glycolytic Process Positive Regulation Of Mitotic Nuclear Division Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of Glucose Import Positive Regulation Of Ras Protein Signal Transduction Insulin-like Growth Factor Receptor Signaling Pathway Phosphatidylinositol-mediated Signaling Positive Regulation Of Fibroblast Proliferation Lung Alveolus Development Positive Regulation Of Smooth Muscle Cell Proliferation Branching Morphogenesis Of An Epithelial Tube Inner Ear Development Chondroitin Sulfate Proteoglycan Biosynthetic Process Positive Regulation Of Epithelial Cell Proliferation Positive Regulation Of Peptidyl-tyrosine Phosphorylation Myoblast Proliferation Positive Regulation Of Protein Kinase B Signaling Negative Regulation Of Oocyte Development Lung Vasculature Development Lung Lobe Morphogenesis Type I Pneumocyte Differentiation Type II Pneumocyte Differentiation Prostate Epithelial Cord Arborization Involved In Prostate Glandular Acinus Morphogenesis Prostate Gland Growth Prostate Gland Stromal Morphogenesis Negative Regulation Of Androgen Receptor Signaling Pathway Negative Regulation Of ERK1 And ERK2 Cascade Positive Regulation Of Calcineurin-NFAT Signaling Cascade Negative Regulation Of Release Of Cytochrome C From Mitochondria Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand Positive Regulation Of Myoblast Proliferation Negative Regulation Of Extrinsic Apoptotic Signaling Pathway
Pathways		Response to elevated platelet cytosolic Ca2+ Iron uptake and transport Platelet degranulation Transferrin endocytosis and recycling Platelet activation, signaling and aggregation	Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) Synthesis, secretion, and deacylation of Ghrelin SHC-related events triggered by IGF1R Platelet degranulation IGF1R signaling cascade IRS-related events triggered by IGF1R Peptide hormone metabolism Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) Response to elevated platelet cytosolic Ca2+ Platelet activation, signaling and aggregation
Drugs		Aluminium
Diseases
GWAS		Alcohol consumption (transferrin glycosylation) ( 21665994) Hepcidin levels ( 21785125) Iron levels ( 21208937) Iron status biomarkers ( 21483845 19084217)	Fasting glucose-related traits ( 20081858) Fasting insulin-related traits ( 20081858) Fasting insulin-related traits (interaction with BMI) ( 22581228) Height ( 19893584 20189936) Thiazide-induced adverse metabolic effects in hypertensive patients ( 23400010)
Protein-Protein Interactions		20 interactors: CALR CANX CUBN GRB2 IGF1 IGF2 IGFBP1 IGFBP2 IGFBP3 IGFBP4 IGFBP5 IGFBP6 LAMC3 SH3BP2 SMAD3 TFR2 TFRC TIMELESS TUBB3 VKORC1	16 interactors: CTSB E2F1 IDE IGF1R IGFALS IGFBP1 IGFBP2 IGFBP3 IGFBP4 IGFBP5 IGFBP6 IGFBP7 IGSF1 NOV TF WISP2
Entrez ID		7018	3479
HPRD ID		01811	00936
Ensembl ID		ENSG00000091513	ENSG00000017427
Uniprot IDs		A0PJA6 J3KN47 P02787 Q06AH7	P05019 Q13429 Q59GC5 Q5U743
PDB IDs		1A8E 1A8F 1B3E 1BP5 1BTJ 1D3K 1D4N 1DTG 1FQE 1FQF 1JQF 1N7W 1N7X 1N84 1OQG 1OQH 1RYO 1SUV 2HAU 2HAV 2O7U 2O84 3FGS 3QYT 3S9L 3S9M 3S9N 3SKP 3V83 3V89 3V8X 3VE1 4H0W	1B9G 1BQT 1GF1 1GZR 1GZY 1GZZ 1H02 1H59 1IMX 1PMX 1TGR 1WQJ 2DSP 2DSQ 2DSR 2GF1 3GF1 3LRI
Enriched GO Terms of Interacting Partners?		Regulation Of Insulin-like Growth Factor Receptor Signaling Pathway Positive Regulation Of Insulin-like Growth Factor Receptor Signaling Pathway Regulation Of Cell Growth Regulation Of Growth Regulation Of Glucose Metabolic Process Regulation Of Cellular Component Organization Developmental Process Regulation Of Carbohydrate Metabolic Process Type B Pancreatic Cell Proliferation Receptor-mediated Endocytosis Regulation Of Signal Transduction Positive Regulation Of Cell Adhesion Positive Regulation Of Activated T Cell Proliferation Regulation Of Signaling Ossification Regulation Of Activated T Cell Proliferation Positive Regulation Of Signal Transduction Osteoblast Differentiation Regulation Of Phosphorylation Regulation Of Smooth Muscle Cell Migration Wound Healing Regulation Of Cell Adhesion Endocytosis Vesicle-mediated Transport Protein Metabolic Process Regulation Of Phosphorus Metabolic Process Regulation Of Cell Proliferation Response To Wounding Anatomical Structure Development System Development Positive Regulation Of T Cell Activation Exocrine Pancreas Development Positive Regulation Of Homotypic Cell-cell Adhesion Striated Muscle Cell Differentiation Positive Regulation Of Protein Kinase B Signaling Cellular Protein Metabolic Process Tissue Development Positive Regulation Of Cell-cell Adhesion Positive Regulation Of T Cell Proliferation Morphogenesis Of An Epithelium Organ Development Positive Regulation Of Phosphorylation Positive Regulation Of Glycogen Biosynthetic Process Developmental Growth Skeletal System Development Regulation Of Smooth Muscle Cell Proliferation Negative Regulation Of Smooth Muscle Cell Migration Multicellular Organismal Development Regulation Of T Cell Activation Positive Regulation Of Cell Activation	Regulation Of Insulin-like Growth Factor Receptor Signaling Pathway Regulation Of Cell Growth Regulation Of Growth Regulation Of Cellular Component Organization Positive Regulation Of Insulin-like Growth Factor Receptor Signaling Pathway Type B Pancreatic Cell Proliferation Signal Transduction Cellular Response To Stimulus Response To Stimulus Cellular Response To Hormone Stimulus Signaling Cell Communication Regulation Of Smooth Muscle Cell Migration Cellular Response To Organic Substance Response To Hormone Regulation Of Cell Proliferation Regulation Of Glucose Metabolic Process Negative Regulation Of Smooth Muscle Cell Migration Response To Organic Substance Cellular Protein Metabolic Process Developmental Process Insulin Receptor Signaling Pathway Regulation Of Carbohydrate Metabolic Process Gland Morphogenesis Regulation Of Signal Transduction Cellular Response To Organonitrogen Compound Regulation Of Cellular Process Regulation Of Cell Death Cellular Response To Insulin Stimulus Regulation Of Signaling Negative Regulation Of Smooth Muscle Cell Proliferation Female Pregnancy Regulation Of Cell Migration Regulation Of Cell Motility Exocrine System Development Ubiquitin Homeostasis Inactivation Of MAPKK Activity Insulin Catabolic Process Protein Metabolic Process Negative Regulation Of Cell Proliferation Regulation Of Locomotion Response To Insulin Regulation Of Cellular Component Movement Regulation Of Steroid Biosynthetic Process Positive Regulation Of Signal Transduction Cellular Response To Peptide Hormone Stimulus Positive Regulation Of Protein Kinase B Signaling Cellular Response To Peptide Reproductive Process Positive Regulation Of Intracellular Signal Transduction
Tagcloud ?		alleviated bhlh c2 c3h10t1 cip coactivator cofactor cognate cor corepressors coup crosstalk forced helix hinge interacted invitro myod myogenic orphan pluripotential repress repression rip13 silences smrt thatcoup transcriptionally waf	alphair3 augmenting blastocyst blastocysts cytoplasm embryo embryos entirely fallopian immunocytochemistry immunoreactive implantation inner intense ivf lining maternal maternally midcycle mimicking paracrine preimplantation reproductive supplementation transcripts tubal tube uterus
Tagcloud (Difference) ?		alleviated bhlh c2 c3h10t1 cip coactivator cofactor cognate cor corepressors coup crosstalk forced helix hinge interacted invitro myod myogenic orphan pluripotential repress repression rip13 silences smrt thatcoup transcriptionally waf	alphair3 augmenting blastocyst blastocysts cytoplasm embryo embryos entirely fallopian immunocytochemistry immunoreactive implantation inner intense ivf lining maternal maternally midcycle mimicking paracrine preimplantation reproductive supplementation transcripts tubal tube uterus
Tagcloud (Intersection) ?