TF and TFR2

Number of citations of the paper that reports this interaction (PMID 11027676)
28

Data Source:
HPRD (in vitro, in vivo)

		TF	TFR2
Gene Name		transferrin	transferrin receptor 2
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Extracellular Region Extracellular Space Early Endosome Late Endosome Coated Pit Basal Plasma Membrane Cell Surface Endosome Membrane Cytoplasmic Membrane-bounded Vesicle Apical Plasma Membrane Endocytic Vesicle Vesicle Secretory Granule Lumen Basal Part Of Cell Perinuclear Region Of Cytoplasm Recycling Endosome Extracellular Vesicular Exosome Blood Microparticle	Cytoplasm Integral Component Of Plasma Membrane
	Molecular Function	Protein Binding Ferric Iron Binding Ubiquitin Protein Ligase Binding	Transferrin Receptor Activity
	Biological Process	Retina Homeostasis Platelet Degranulation Cellular Iron Ion Homeostasis Blood Coagulation Platelet Activation Transferrin Transport Transmembrane Transport	Iron Ion Transport Cellular Iron Ion Homeostasis Receptor-mediated Endocytosis
Pathways		Response to elevated platelet cytosolic Ca2+ Iron uptake and transport Platelet degranulation Transferrin endocytosis and recycling Platelet activation, signaling and aggregation
Drugs		Aluminium
Diseases
GWAS		Alcohol consumption (transferrin glycosylation) ( 21665994) Hepcidin levels ( 21785125) Iron levels ( 21208937) Iron status biomarkers ( 21483845 19084217)	Hematocrit ( 19862010) Hematological parameters ( 19820697) Iron levels ( 21208937) Mean corpuscular volume ( 19862010) Red blood cell traits ( 23222517)
Protein-Protein Interactions		20 interactors: CALR CANX CUBN GRB2 IGF1 IGF2 IGFBP1 IGFBP2 IGFBP3 IGFBP4 IGFBP5 IGFBP6 LAMC3 SH3BP2 SMAD3 TFR2 TFRC TIMELESS TUBB3 VKORC1	3 interactors: HFE SOCS3 TF
Entrez ID		7018	7036
HPRD ID		01811	05282
Ensembl ID		ENSG00000091513	ENSG00000106327
Uniprot IDs		A0PJA6 J3KN47 P02787 Q06AH7	Q9UP52
PDB IDs		1A8E 1A8F 1B3E 1BP5 1BTJ 1D3K 1D4N 1DTG 1FQE 1FQF 1JQF 1N7W 1N7X 1N84 1OQG 1OQH 1RYO 1SUV 2HAU 2HAV 2O7U 2O84 3FGS 3QYT 3S9L 3S9M 3S9N 3SKP 3V83 3V89 3V8X 3VE1 4H0W
Enriched GO Terms of Interacting Partners?		Regulation Of Insulin-like Growth Factor Receptor Signaling Pathway Positive Regulation Of Insulin-like Growth Factor Receptor Signaling Pathway Regulation Of Cell Growth Regulation Of Growth Regulation Of Glucose Metabolic Process Regulation Of Cellular Component Organization Developmental Process Regulation Of Carbohydrate Metabolic Process Type B Pancreatic Cell Proliferation Receptor-mediated Endocytosis Regulation Of Signal Transduction Positive Regulation Of Cell Adhesion Positive Regulation Of Activated T Cell Proliferation Regulation Of Signaling Ossification Regulation Of Activated T Cell Proliferation Positive Regulation Of Signal Transduction Osteoblast Differentiation Regulation Of Phosphorylation Regulation Of Smooth Muscle Cell Migration Wound Healing Regulation Of Cell Adhesion Endocytosis Vesicle-mediated Transport Protein Metabolic Process Regulation Of Phosphorus Metabolic Process Regulation Of Cell Proliferation Response To Wounding Anatomical Structure Development System Development Positive Regulation Of T Cell Activation Exocrine Pancreas Development Positive Regulation Of Homotypic Cell-cell Adhesion Striated Muscle Cell Differentiation Positive Regulation Of Protein Kinase B Signaling Cellular Protein Metabolic Process Tissue Development Positive Regulation Of Cell-cell Adhesion Positive Regulation Of T Cell Proliferation Morphogenesis Of An Epithelium Organ Development Positive Regulation Of Phosphorylation Positive Regulation Of Glycogen Biosynthetic Process Developmental Growth Skeletal System Development Regulation Of Smooth Muscle Cell Proliferation Negative Regulation Of Smooth Muscle Cell Migration Multicellular Organismal Development Regulation Of T Cell Activation Positive Regulation Of Cell Activation	Iron Ion Transport Cellular Iron Ion Homeostasis Iron Ion Homeostasis Transition Metal Ion Homeostasis Cellular Response To Iron Ion Starvation Multicellular Organismal Homeostasis Spongiotrophoblast Differentiation Iron Ion Import Into Cell Cellular Metal Ion Homeostasis Cellular Cation Homeostasis Cellular Ion Homeostasis Metal Ion Homeostasis Branching Involved In Labyrinthine Layer Morphogenesis Cellular Chemical Homeostasis Ion Homeostasis Iron Ion Import Spongiotrophoblast Layer Development Multicellular Organismal Iron Ion Homeostasis Cellular Homeostasis Trophoblast Giant Cell Differentiation Regulation Of Interferon-gamma-mediated Signaling Pathway JAK-STAT Cascade Involved In Growth Hormone Signaling Pathway Regulation Of Response To Interferon-gamma Negative Regulation Of JAK-STAT Cascade Labyrinthine Layer Morphogenesis Growth Hormone Receptor Signaling Pathway Response To Stress Cellular Response To Growth Hormone Stimulus Embryonic Placenta Morphogenesis Metal Ion Transport Chemical Homeostasis Regulation Of Immune Response Transferrin Transport Cell Differentiation Involved In Embryonic Placenta Development Placenta Blood Vessel Development Negative Regulation Of Insulin Receptor Signaling Pathway Response To Growth Hormone Regulation Of Type I Interferon-mediated Signaling Pathway Hormone Biosynthetic Process JAK-STAT Cascade Cation Transport Labyrinthine Layer Development Retina Homeostasis Regulation Of Insulin Receptor Signaling Pathway Immune Response Regulation Of Immune System Process Platelet Degranulation Reproductive Process Homeostatic Process Regulation Of Cellular Response To Insulin Stimulus
Tagcloud ?		alleviated bhlh c2 c3h10t1 cip coactivator cofactor cognate cor corepressors coup crosstalk forced helix hinge interacted invitro myod myogenic orphan pluripotential repress repression rip13 silences smrt thatcoup transcriptionally waf	arrays chemotaxis complement congenital count counts cxcr2 exome frameshift genotyped hbb hematocrit hematological hematopoiesis hemoglobin identifying missense neutropenia pedigree platelet resequencing separate sh2b3 splice traits tubb1 val617phe variants wbc
Tagcloud (Difference) ?		alleviated bhlh c2 c3h10t1 cip coactivator cofactor cognate cor corepressors coup crosstalk forced helix hinge interacted invitro myod myogenic orphan pluripotential repress repression rip13 silences smrt thatcoup transcriptionally waf	arrays chemotaxis complement congenital count counts cxcr2 exome frameshift genotyped hbb hematocrit hematological hematopoiesis hemoglobin identifying missense neutropenia pedigree platelet resequencing separate sh2b3 splice traits tubb1 val617phe variants wbc
Tagcloud (Intersection) ?