IGF1 and IGFBP7

Number of citations of the paper that reports this interaction (PMID 8939990)
29

Data Source:
HPRD (in vitro)

		IGF1	IGFBP7
Gene Name		insulin-like growth factor 1 (somatomedin C)	insulin-like growth factor binding protein 7
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Extracellular Region Extracellular Space Plasma Membrane Insulin-like Growth Factor Binding Protein Complex Platelet Alpha Granule Lumen	Extracellular Region Extracellular Space Extracellular Matrix Extracellular Vesicular Exosome
	Molecular Function	Insulin Receptor Binding Insulin-like Growth Factor Receptor Binding Integrin Binding Hormone Activity Protein Binding Growth Factor Activity	Protein Binding Insulin-like Growth Factor Binding
	Biological Process	Skeletal System Development Cell Activation Blood Vessel Remodeling Platelet Degranulation DNA Replication Movement Of Cell Or Subcellular Component Signal Transduction Ras Protein Signal Transduction Muscle Organ Development Blood Coagulation Positive Regulation Of Cell Proliferation Negative Regulation Of Cell Proliferation Response To Heat Glycolate Metabolic Process Glial Cell Differentiation Regulation Of Gene Expression Positive Regulation Of Cardiac Muscle Hypertrophy Positive Regulation Of Phosphatidylinositol 3-kinase Signaling Skeletal Muscle Satellite Cell Maintenance Involved In Skeletal Muscle Regeneration Muscle Hypertrophy Myotube Cell Development Positive Regulation Of Smooth Muscle Cell Migration Positive Regulation Of Cerebellar Granule Cell Precursor Proliferation Water Homeostasis Proteoglycan Biosynthetic Process Platelet Activation Mammary Gland Development Exocrine Pancreas Development Regulation Of Establishment Or Maintenance Of Cell Polarity Positive Regulation Of Protein Import Into Nucleus, Translocation Negative Regulation Of Smooth Muscle Cell Apoptotic Process Multicellular Organism Growth Bone Mineralization Involved In Bone Maturation Regulation Of Multicellular Organism Growth Positive Regulation Of Activated T Cell Proliferation Positive Regulation Of Tyrosine Phosphorylation Of Stat5 Protein Negative Regulation Of Apoptotic Process Positive Regulation Of DNA Binding Positive Regulation Of MAPK Cascade Positive Regulation Of Insulin-like Growth Factor Receptor Signaling Pathway Cellular Protein Metabolic Process Myoblast Differentiation Positive Regulation Of Osteoblast Differentiation Positive Regulation Of Glycogen Biosynthetic Process Positive Regulation Of DNA Replication Positive Regulation Of Glycolytic Process Positive Regulation Of Mitotic Nuclear Division Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of Glucose Import Positive Regulation Of Ras Protein Signal Transduction Insulin-like Growth Factor Receptor Signaling Pathway Phosphatidylinositol-mediated Signaling Positive Regulation Of Fibroblast Proliferation Lung Alveolus Development Positive Regulation Of Smooth Muscle Cell Proliferation Branching Morphogenesis Of An Epithelial Tube Inner Ear Development Chondroitin Sulfate Proteoglycan Biosynthetic Process Positive Regulation Of Epithelial Cell Proliferation Positive Regulation Of Peptidyl-tyrosine Phosphorylation Myoblast Proliferation Positive Regulation Of Protein Kinase B Signaling Negative Regulation Of Oocyte Development Lung Vasculature Development Lung Lobe Morphogenesis Type I Pneumocyte Differentiation Type II Pneumocyte Differentiation Prostate Epithelial Cord Arborization Involved In Prostate Glandular Acinus Morphogenesis Prostate Gland Growth Prostate Gland Stromal Morphogenesis Negative Regulation Of Androgen Receptor Signaling Pathway Negative Regulation Of ERK1 And ERK2 Cascade Positive Regulation Of Calcineurin-NFAT Signaling Cascade Negative Regulation Of Release Of Cytochrome C From Mitochondria Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand Positive Regulation Of Myoblast Proliferation Negative Regulation Of Extrinsic Apoptotic Signaling Pathway	Regulation Of Cell Growth Cell Adhesion Embryo Implantation Negative Regulation Of Cell Proliferation Response To Heat Response To Retinoic Acid Cellular Response To Hormone Stimulus Inner Ear Development Regulation Of Steroid Biosynthetic Process Response To Cortisol
Pathways		Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) Synthesis, secretion, and deacylation of Ghrelin SHC-related events triggered by IGF1R Platelet degranulation IGF1R signaling cascade IRS-related events triggered by IGF1R Peptide hormone metabolism Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) Response to elevated platelet cytosolic Ca2+ Platelet activation, signaling and aggregation	Cellular Senescence Senescence-Associated Secretory Phenotype (SASP)
Drugs
Diseases
GWAS		Fasting glucose-related traits ( 20081858) Fasting insulin-related traits ( 20081858) Fasting insulin-related traits (interaction with BMI) ( 22581228) Height ( 19893584 20189936) Thiazide-induced adverse metabolic effects in hypertensive patients ( 23400010)	Age-related macular degeneration ( 21909106)
Protein-Protein Interactions		16 interactors: CTSB E2F1 IDE IGF1R IGFALS IGFBP1 IGFBP2 IGFBP3 IGFBP4 IGFBP5 IGFBP6 IGFBP7 IGSF1 NOV TF WISP2	11 interactors: CCL21 CCL5 CHMP3 CXCL10 IGF1 IGF2 INHBA INS RBBP8 SDC1 VEGFA
Entrez ID		3479	3490
HPRD ID		00936	04183
Ensembl ID		ENSG00000017427	ENSG00000163453
Uniprot IDs		P05019 Q13429 Q59GC5 Q5U743	Q16270
PDB IDs		1B9G 1BQT 1GF1 1GZR 1GZY 1GZZ 1H02 1H59 1IMX 1PMX 1TGR 1WQJ 2DSP 2DSQ 2DSR 2GF1 3GF1 3LRI
Enriched GO Terms of Interacting Partners?		Regulation Of Insulin-like Growth Factor Receptor Signaling Pathway Regulation Of Cell Growth Regulation Of Growth Regulation Of Cellular Component Organization Positive Regulation Of Insulin-like Growth Factor Receptor Signaling Pathway Type B Pancreatic Cell Proliferation Signal Transduction Cellular Response To Stimulus Response To Stimulus Cellular Response To Hormone Stimulus Signaling Cell Communication Regulation Of Smooth Muscle Cell Migration Cellular Response To Organic Substance Response To Hormone Regulation Of Cell Proliferation Regulation Of Glucose Metabolic Process Negative Regulation Of Smooth Muscle Cell Migration Response To Organic Substance Cellular Protein Metabolic Process Developmental Process Insulin Receptor Signaling Pathway Regulation Of Carbohydrate Metabolic Process Gland Morphogenesis Regulation Of Signal Transduction Cellular Response To Organonitrogen Compound Regulation Of Cellular Process Regulation Of Cell Death Cellular Response To Insulin Stimulus Regulation Of Signaling Negative Regulation Of Smooth Muscle Cell Proliferation Female Pregnancy Regulation Of Cell Migration Regulation Of Cell Motility Exocrine System Development Ubiquitin Homeostasis Inactivation Of MAPKK Activity Insulin Catabolic Process Protein Metabolic Process Negative Regulation Of Cell Proliferation Regulation Of Locomotion Response To Insulin Regulation Of Cellular Component Movement Regulation Of Steroid Biosynthetic Process Positive Regulation Of Signal Transduction Cellular Response To Peptide Hormone Stimulus Positive Regulation Of Protein Kinase B Signaling Cellular Response To Peptide Reproductive Process Positive Regulation Of Intracellular Signal Transduction	Positive Regulation Of Transport Positive Regulation Of Protein Kinase B Signaling Regulation Of Protein Kinase B Signaling Regulation Of Protein Phosphorylation Positive Regulation Of Cell Migration Positive Regulation Of Cell Motility Positive Regulation Of Cellular Component Movement Positive Regulation Of Locomotion Positive Regulation Of Peptidyl-tyrosine Phosphorylation Positive Regulation Of Protein Phosphorylation Regulation Of Cellular Component Organization Positive Regulation Of Signal Transduction Positive Regulation Of Organelle Organization Regulation Of Immune System Process Regulation Of Phosphorylation Regulation Of Behavior Positive Regulation Of Intracellular Signal Transduction Positive Regulation Of Leukocyte Chemotaxis Positive Regulation Of Glycogen Biosynthetic Process Regulation Of Peptidyl-tyrosine Phosphorylation Positive Regulation Of Phosphorylation Regulation Of Phosphorus Metabolic Process Positive Regulation Of Immune System Process Positive Regulation Of Protein Modification Process Regulation Of Organelle Organization Positive Regulation Of Macromolecule Biosynthetic Process Secretion By Cell Response To Stress Positive Regulation Of Leukocyte Migration Positive Regulation Of Cellular Biosynthetic Process Positive Regulation Of T Cell Migration Regulation Of Cellular Localization Regulation Of T Cell Migration Regulation Of Cell Migration Leukocyte Chemotaxis Regulation Of Intracellular Signal Transduction Regulation Of MAPK Cascade Positive Regulation Of Chemotaxis Positive Regulation Of Cellular Protein Metabolic Process Regulation Of Cell Motility Secretion Regulation Of Leukocyte Migration Positive Regulation Of Cell Division Regulation Of Locomotion Cell Activation Positive Regulation Of Behavior Regulation Of Cellular Component Movement Positive Regulation Of Protein Metabolic Process Regulation Of Cellular Protein Metabolic Process Regulation Of Chemotaxis
Tagcloud ?		alphair3 augmenting blastocyst blastocysts cytoplasm embryo embryos entirely fallopian immunocytochemistry immunoreactive implantation inner intense ivf lining maternal maternally midcycle mimicking paracrine preimplantation reproductive supplementation transcripts tubal tube uterus	achieve additive aza dc demethylating demethylation deoxycytidine difficult dual efficiently epigenetic exists ezh2 focusing gsk126 h3k27me3 limitation methylated methylation modification modifications overcome preferentially promising re sfrp1 trimethylation utilized xenograft
Tagcloud (Difference) ?		alphair3 augmenting blastocyst blastocysts cytoplasm embryo embryos entirely fallopian immunocytochemistry immunoreactive implantation inner intense ivf lining maternal maternally midcycle mimicking paracrine preimplantation reproductive supplementation transcripts tubal tube uterus	achieve additive aza dc demethylating demethylation deoxycytidine difficult dual efficiently epigenetic exists ezh2 focusing gsk126 h3k27me3 limitation methylated methylation modification modifications overcome preferentially promising re sfrp1 trimethylation utilized xenograft
Tagcloud (Intersection) ?