IGF1 and IGFBP2

Number of citations of the paper that reports this interaction (PMID 11063745)
4

Data Source:
BioGRID (biochemical)
HPRD (in vitro)

		IGF1	IGFBP2
Gene Name		insulin-like growth factor 1 (somatomedin C)	insulin-like growth factor binding protein 2, 36kDa
Image
Gene Ontology Annotations	Cellular Component	Extracellular Region Extracellular Space Plasma Membrane Insulin-like Growth Factor Binding Protein Complex Platelet Alpha Granule Lumen	Extracellular Region Extracellular Space Apical Plasma Membrane Cytoplasmic Vesicle Extracellular Vesicular Exosome
	Molecular Function	Insulin Receptor Binding Insulin-like Growth Factor Receptor Binding Integrin Binding Hormone Activity Protein Binding Growth Factor Activity	Protein Binding Insulin-like Growth Factor I Binding Insulin-like Growth Factor II Binding
	Biological Process	Skeletal System Development Cell Activation Blood Vessel Remodeling Platelet Degranulation DNA Replication Movement Of Cell Or Subcellular Component Signal Transduction Ras Protein Signal Transduction Muscle Organ Development Blood Coagulation Positive Regulation Of Cell Proliferation Negative Regulation Of Cell Proliferation Response To Heat Glycolate Metabolic Process Glial Cell Differentiation Regulation Of Gene Expression Positive Regulation Of Cardiac Muscle Hypertrophy Positive Regulation Of Phosphatidylinositol 3-kinase Signaling Skeletal Muscle Satellite Cell Maintenance Involved In Skeletal Muscle Regeneration Muscle Hypertrophy Myotube Cell Development Positive Regulation Of Smooth Muscle Cell Migration Positive Regulation Of Cerebellar Granule Cell Precursor Proliferation Water Homeostasis Proteoglycan Biosynthetic Process Platelet Activation Mammary Gland Development Exocrine Pancreas Development Regulation Of Establishment Or Maintenance Of Cell Polarity Positive Regulation Of Protein Import Into Nucleus, Translocation Negative Regulation Of Smooth Muscle Cell Apoptotic Process Multicellular Organism Growth Bone Mineralization Involved In Bone Maturation Regulation Of Multicellular Organism Growth Positive Regulation Of Activated T Cell Proliferation Positive Regulation Of Tyrosine Phosphorylation Of Stat5 Protein Negative Regulation Of Apoptotic Process Positive Regulation Of DNA Binding Positive Regulation Of MAPK Cascade Positive Regulation Of Insulin-like Growth Factor Receptor Signaling Pathway Cellular Protein Metabolic Process Myoblast Differentiation Positive Regulation Of Osteoblast Differentiation Positive Regulation Of Glycogen Biosynthetic Process Positive Regulation Of DNA Replication Positive Regulation Of Glycolytic Process Positive Regulation Of Mitotic Nuclear Division Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of Glucose Import Positive Regulation Of Ras Protein Signal Transduction Insulin-like Growth Factor Receptor Signaling Pathway Phosphatidylinositol-mediated Signaling Positive Regulation Of Fibroblast Proliferation Lung Alveolus Development Positive Regulation Of Smooth Muscle Cell Proliferation Branching Morphogenesis Of An Epithelial Tube Inner Ear Development Chondroitin Sulfate Proteoglycan Biosynthetic Process Positive Regulation Of Epithelial Cell Proliferation Positive Regulation Of Peptidyl-tyrosine Phosphorylation Myoblast Proliferation Positive Regulation Of Protein Kinase B Signaling Negative Regulation Of Oocyte Development Lung Vasculature Development Lung Lobe Morphogenesis Type I Pneumocyte Differentiation Type II Pneumocyte Differentiation Prostate Epithelial Cord Arborization Involved In Prostate Glandular Acinus Morphogenesis Prostate Gland Growth Prostate Gland Stromal Morphogenesis Negative Regulation Of Androgen Receptor Signaling Pathway Negative Regulation Of ERK1 And ERK2 Cascade Positive Regulation Of Calcineurin-NFAT Signaling Cascade Negative Regulation Of Release Of Cytochrome C From Mitochondria Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand Positive Regulation Of Myoblast Proliferation Negative Regulation Of Extrinsic Apoptotic Signaling Pathway	Regulation Of Cell Growth Signal Transduction Female Pregnancy Aging Response To Nutrient Response To Mechanical Stimulus Response To Lithium Ion Response To Estradiol Response To Retinoic Acid Cellular Response To Hormone Stimulus Positive Regulation Of Activated T Cell Proliferation Response To Drug Regulation Of Insulin-like Growth Factor Receptor Signaling Pathway Cellular Protein Metabolic Process Response To Glucocorticoid
Pathways		Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) Synthesis, secretion, and deacylation of Ghrelin SHC-related events triggered by IGF1R Platelet degranulation IGF1R signaling cascade IRS-related events triggered by IGF1R Peptide hormone metabolism Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) Response to elevated platelet cytosolic Ca2+ Platelet activation, signaling and aggregation	Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)
Drugs
Diseases
GWAS		Fasting glucose-related traits ( 20081858) Fasting insulin-related traits ( 20081858) Fasting insulin-related traits (interaction with BMI) ( 22581228) Height ( 19893584 20189936) Thiazide-induced adverse metabolic effects in hypertensive patients ( 23400010)
Protein-Protein Interactions		16 interactors: CTSB E2F1 IDE IGF1R IGFALS IGFBP1 IGFBP2 IGFBP3 IGFBP4 IGFBP5 IGFBP6 IGFBP7 IGSF1 NOV TF WISP2	6 interactors: GSDMB IGF1 IGF2 INO80B KLK2 TF
Entrez ID		3479	3485
HPRD ID		00936	00898
Ensembl ID		ENSG00000017427	ENSG00000115457
Uniprot IDs		P05019 Q13429 Q59GC5 Q5U743	C9JMY1 P18065
PDB IDs		1B9G 1BQT 1GF1 1GZR 1GZY 1GZZ 1H02 1H59 1IMX 1PMX 1TGR 1WQJ 2DSP 2DSQ 2DSR 2GF1 3GF1 3LRI	2H7T
Enriched GO Terms of Interacting Partners?		Regulation Of Insulin-like Growth Factor Receptor Signaling Pathway Regulation Of Cell Growth Regulation Of Growth Regulation Of Cellular Component Organization Positive Regulation Of Insulin-like Growth Factor Receptor Signaling Pathway Type B Pancreatic Cell Proliferation Signal Transduction Cellular Response To Stimulus Response To Stimulus Cellular Response To Hormone Stimulus Signaling Cell Communication Regulation Of Smooth Muscle Cell Migration Cellular Response To Organic Substance Response To Hormone Regulation Of Cell Proliferation Regulation Of Glucose Metabolic Process Negative Regulation Of Smooth Muscle Cell Migration Response To Organic Substance Cellular Protein Metabolic Process Developmental Process Insulin Receptor Signaling Pathway Regulation Of Carbohydrate Metabolic Process Gland Morphogenesis Regulation Of Signal Transduction Cellular Response To Organonitrogen Compound Regulation Of Cellular Process Regulation Of Cell Death Cellular Response To Insulin Stimulus Regulation Of Signaling Negative Regulation Of Smooth Muscle Cell Proliferation Female Pregnancy Regulation Of Cell Migration Regulation Of Cell Motility Exocrine System Development Ubiquitin Homeostasis Inactivation Of MAPKK Activity Insulin Catabolic Process Protein Metabolic Process Negative Regulation Of Cell Proliferation Regulation Of Locomotion Response To Insulin Regulation Of Cellular Component Movement Regulation Of Steroid Biosynthetic Process Positive Regulation Of Signal Transduction Cellular Response To Peptide Hormone Stimulus Positive Regulation Of Protein Kinase B Signaling Cellular Response To Peptide Reproductive Process Positive Regulation Of Intracellular Signal Transduction	Platelet Degranulation Exocrine Pancreas Development Positive Regulation Of Glycogen Biosynthetic Process Platelet Activation Positive Regulation Of Activated T Cell Proliferation Regulation Of Glycogen Biosynthetic Process Positive Regulation Of Glucose Metabolic Process Regulation Of Activated T Cell Proliferation Regulation Of Glycogen Metabolic Process Exocytosis Positive Regulation Of Mitotic Nuclear Division Blood Coagulation Hemostasis Exocrine System Development Secretion By Cell Regulation Of Generation Of Precursor Metabolites And Energy Positive Regulation Of Protein Kinase B Signaling Positive Regulation Of T Cell Proliferation Regulation Of Body Fluid Levels Wound Healing Pancreas Development Secretion Regulation Of Glucose Metabolic Process Cell Activation Positive Regulation Of Lymphocyte Proliferation Positive Regulation Of Mononuclear Cell Proliferation Positive Regulation Of Mitotic Cell Cycle Response To Wounding Regulation Of Mitotic Nuclear Division Regulation Of Protein Kinase B Signaling Positive Regulation Of Cell Division Regulation Of T Cell Proliferation Digestive System Development Regulation Of Carbohydrate Metabolic Process Positive Regulation Of Peptidyl-tyrosine Phosphorylation Prostate Gland Stromal Morphogenesis Glycolate Metabolic Process Positive Regulation Of T Cell Activation Regulation Of Peptidyl-tyrosine Phosphorylation Negative Regulation Of Oocyte Development Insulin Receptor Signaling Pathway Via Phosphatidylinositol 3-kinase Skeletal Muscle Satellite Cell Maintenance Involved In Skeletal Muscle Regeneration Positive Regulation Of Homotypic Cell-cell Adhesion Positive Regulation Of Cell Cycle Process Striated Muscle Cell Differentiation Positive Regulation Of Glycogen (starch) Synthase Activity Positive Regulation Of Cell-cell Adhesion Regulation Of Cell Division Positive Regulation Of Myoblast Proliferation Myoblast Proliferation
Tagcloud ?		alphair3 augmenting blastocyst blastocysts cytoplasm embryo embryos entirely fallopian immunocytochemistry immunoreactive implantation inner intense ivf lining maternal maternally midcycle mimicking paracrine preimplantation reproductive supplementation transcripts tubal tube uterus	anabolic astrocytes carotid cerebral extremely hemisphere hypoxia hypoxic immature immediate impending insult insults ipsilateral ischemia ischemic ligation messenger myelinogenesis perinatal permanent perturbations pleiotrophic pronounced recovery thalamus vulnerability vulnerable
Tagcloud (Difference) ?		alphair3 augmenting blastocyst blastocysts cytoplasm embryo embryos entirely fallopian immunocytochemistry immunoreactive implantation inner intense ivf lining maternal maternally midcycle mimicking paracrine preimplantation reproductive supplementation transcripts tubal tube uterus	anabolic astrocytes carotid cerebral extremely hemisphere hypoxia hypoxic immature immediate impending insult insults ipsilateral ischemia ischemic ligation messenger myelinogenesis perinatal permanent perturbations pleiotrophic pronounced recovery thalamus vulnerability vulnerable
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