TF and IGFBP2

Number of citations of the paper that reports this interaction (PMID 11297622)
20

Data Source:
HPRD (in vitro)

		TF	IGFBP2
Gene Name		transferrin	insulin-like growth factor binding protein 2, 36kDa
Image
Gene Ontology Annotations	Cellular Component	Extracellular Region Extracellular Space Early Endosome Late Endosome Coated Pit Basal Plasma Membrane Cell Surface Endosome Membrane Cytoplasmic Membrane-bounded Vesicle Apical Plasma Membrane Endocytic Vesicle Vesicle Secretory Granule Lumen Basal Part Of Cell Perinuclear Region Of Cytoplasm Recycling Endosome Extracellular Vesicular Exosome Blood Microparticle	Extracellular Region Extracellular Space Apical Plasma Membrane Cytoplasmic Vesicle Extracellular Vesicular Exosome
	Molecular Function	Protein Binding Ferric Iron Binding Ubiquitin Protein Ligase Binding	Protein Binding Insulin-like Growth Factor I Binding Insulin-like Growth Factor II Binding
	Biological Process	Retina Homeostasis Platelet Degranulation Cellular Iron Ion Homeostasis Blood Coagulation Platelet Activation Transferrin Transport Transmembrane Transport	Regulation Of Cell Growth Signal Transduction Female Pregnancy Aging Response To Nutrient Response To Mechanical Stimulus Response To Lithium Ion Response To Estradiol Response To Retinoic Acid Cellular Response To Hormone Stimulus Positive Regulation Of Activated T Cell Proliferation Response To Drug Regulation Of Insulin-like Growth Factor Receptor Signaling Pathway Cellular Protein Metabolic Process Response To Glucocorticoid
Pathways		Response to elevated platelet cytosolic Ca2+ Iron uptake and transport Platelet degranulation Transferrin endocytosis and recycling Platelet activation, signaling and aggregation	Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)
Drugs		Aluminium
Diseases
GWAS		Alcohol consumption (transferrin glycosylation) ( 21665994) Hepcidin levels ( 21785125) Iron levels ( 21208937) Iron status biomarkers ( 21483845 19084217)
Protein-Protein Interactions		20 interactors: CALR CANX CUBN GRB2 IGF1 IGF2 IGFBP1 IGFBP2 IGFBP3 IGFBP4 IGFBP5 IGFBP6 LAMC3 SH3BP2 SMAD3 TFR2 TFRC TIMELESS TUBB3 VKORC1	6 interactors: GSDMB IGF1 IGF2 INO80B KLK2 TF
Entrez ID		7018	3485
HPRD ID		01811	00898
Ensembl ID		ENSG00000091513	ENSG00000115457
Uniprot IDs		A0PJA6 J3KN47 P02787 Q06AH7	C9JMY1 P18065
PDB IDs		1A8E 1A8F 1B3E 1BP5 1BTJ 1D3K 1D4N 1DTG 1FQE 1FQF 1JQF 1N7W 1N7X 1N84 1OQG 1OQH 1RYO 1SUV 2HAU 2HAV 2O7U 2O84 3FGS 3QYT 3S9L 3S9M 3S9N 3SKP 3V83 3V89 3V8X 3VE1 4H0W	2H7T
Enriched GO Terms of Interacting Partners?		Regulation Of Insulin-like Growth Factor Receptor Signaling Pathway Positive Regulation Of Insulin-like Growth Factor Receptor Signaling Pathway Regulation Of Cell Growth Regulation Of Growth Regulation Of Glucose Metabolic Process Regulation Of Cellular Component Organization Developmental Process Regulation Of Carbohydrate Metabolic Process Type B Pancreatic Cell Proliferation Receptor-mediated Endocytosis Regulation Of Signal Transduction Positive Regulation Of Cell Adhesion Positive Regulation Of Activated T Cell Proliferation Regulation Of Signaling Ossification Regulation Of Activated T Cell Proliferation Positive Regulation Of Signal Transduction Osteoblast Differentiation Regulation Of Phosphorylation Regulation Of Smooth Muscle Cell Migration Wound Healing Regulation Of Cell Adhesion Endocytosis Vesicle-mediated Transport Protein Metabolic Process Regulation Of Phosphorus Metabolic Process Regulation Of Cell Proliferation Response To Wounding Anatomical Structure Development System Development Positive Regulation Of T Cell Activation Exocrine Pancreas Development Positive Regulation Of Homotypic Cell-cell Adhesion Striated Muscle Cell Differentiation Positive Regulation Of Protein Kinase B Signaling Cellular Protein Metabolic Process Tissue Development Positive Regulation Of Cell-cell Adhesion Positive Regulation Of T Cell Proliferation Morphogenesis Of An Epithelium Organ Development Positive Regulation Of Phosphorylation Positive Regulation Of Glycogen Biosynthetic Process Developmental Growth Skeletal System Development Regulation Of Smooth Muscle Cell Proliferation Negative Regulation Of Smooth Muscle Cell Migration Multicellular Organismal Development Regulation Of T Cell Activation Positive Regulation Of Cell Activation	Platelet Degranulation Exocrine Pancreas Development Positive Regulation Of Glycogen Biosynthetic Process Platelet Activation Positive Regulation Of Activated T Cell Proliferation Regulation Of Glycogen Biosynthetic Process Positive Regulation Of Glucose Metabolic Process Regulation Of Activated T Cell Proliferation Regulation Of Glycogen Metabolic Process Exocytosis Positive Regulation Of Mitotic Nuclear Division Blood Coagulation Hemostasis Exocrine System Development Secretion By Cell Regulation Of Generation Of Precursor Metabolites And Energy Positive Regulation Of Protein Kinase B Signaling Positive Regulation Of T Cell Proliferation Regulation Of Body Fluid Levels Wound Healing Pancreas Development Secretion Regulation Of Glucose Metabolic Process Cell Activation Positive Regulation Of Lymphocyte Proliferation Positive Regulation Of Mononuclear Cell Proliferation Positive Regulation Of Mitotic Cell Cycle Response To Wounding Regulation Of Mitotic Nuclear Division Regulation Of Protein Kinase B Signaling Positive Regulation Of Cell Division Regulation Of T Cell Proliferation Digestive System Development Regulation Of Carbohydrate Metabolic Process Positive Regulation Of Peptidyl-tyrosine Phosphorylation Prostate Gland Stromal Morphogenesis Glycolate Metabolic Process Positive Regulation Of T Cell Activation Regulation Of Peptidyl-tyrosine Phosphorylation Negative Regulation Of Oocyte Development Insulin Receptor Signaling Pathway Via Phosphatidylinositol 3-kinase Skeletal Muscle Satellite Cell Maintenance Involved In Skeletal Muscle Regeneration Positive Regulation Of Homotypic Cell-cell Adhesion Positive Regulation Of Cell Cycle Process Striated Muscle Cell Differentiation Positive Regulation Of Glycogen (starch) Synthase Activity Positive Regulation Of Cell-cell Adhesion Regulation Of Cell Division Positive Regulation Of Myoblast Proliferation Myoblast Proliferation
Tagcloud ?		alleviated bhlh c2 c3h10t1 cip coactivator cofactor cognate cor corepressors coup crosstalk forced helix hinge interacted invitro myod myogenic orphan pluripotential repress repression rip13 silences smrt thatcoup transcriptionally waf	anabolic astrocytes carotid cerebral extremely hemisphere hypoxia hypoxic immature immediate impending insult insults ipsilateral ischemia ischemic ligation messenger myelinogenesis perinatal permanent perturbations pleiotrophic pronounced recovery thalamus vulnerability vulnerable
Tagcloud (Difference) ?		alleviated bhlh c2 c3h10t1 cip coactivator cofactor cognate cor corepressors coup crosstalk forced helix hinge interacted invitro myod myogenic orphan pluripotential repress repression rip13 silences smrt thatcoup transcriptionally waf	anabolic astrocytes carotid cerebral extremely hemisphere hypoxia hypoxic immature immediate impending insult insults ipsilateral ischemia ischemic ligation messenger myelinogenesis perinatal permanent perturbations pleiotrophic pronounced recovery thalamus vulnerability vulnerable
Tagcloud (Intersection) ?