TERC and DKC1

Number of citations of the paper that reports this interaction (PMID 18082603)
43

Data Source:
BioGRID (affinity chromatography technology, unspecified method)

		TERC	DKC1
Gene Name		telomerase RNA component	dyskeratosis congenita 1, dyskerin
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component		Nucleus Nucleoplasm Telomerase Holoenzyme Complex Nucleolus Cytoplasm Cajal Body
	Molecular Function		Telomerase Activity RNA Binding Protein Binding Pseudouridine Synthase Activity Poly(A) RNA Binding
	Biological Process		Telomere Maintenance Pseudouridine Synthesis RRNA Processing RNA Processing Telomere Maintenance Via Telomerase Cell Proliferation
Pathways			Telomere Maintenance Chromosome Maintenance Extension of Telomeres Telomere Extension By Telomerase
Drugs
Diseases
GWAS		Telomere length ( 23535734 21573004 20139977 23001564)
Protein-Protein Interactions		1 interactors: DKC1	10 interactors: CSNK2A1 EEF1G EIF3F ERG LYPLA2 MAPK6 RUVBL1 SHQ1 SSR1 TERC
Entrez ID		7012	1736
HPRD ID			02129
Ensembl ID		ENSG00000270141	ENSG00000130826
Uniprot IDs			O60832
PDB IDs
Enriched GO Terms of Interacting Partners?		Telomere Maintenance Via Telomerase RNA-dependent DNA Replication Telomere Maintenance Via Telomere Lengthening Pseudouridine Synthesis Telomere Maintenance DNA Biosynthetic Process RRNA Processing RRNA Metabolic Process RNA Modification Ribosome Biogenesis DNA Replication Ribonucleoprotein Complex Biogenesis	Cellular Protein Metabolic Process Negative Regulation Of Potassium Ion Export Gene Expression Cellular Macromolecule Biosynthetic Process Macromolecule Biosynthetic Process Negative Regulation Of RRNA Processing Regulation Of Heart Rate By Hormone Protein Metabolic Process Cellular Macromolecular Complex Assembly Negative Regulation Of Ribosome Biogenesis Translation Ribonucleoprotein Complex Assembly
Tagcloud ?		anticancer catalytic cloned compensate division elucidated encoding erosion fusions generally homolog immortality length neoplasms p80 protection repeat repeats repressed ribonucleoprotein telomerase telomere telomeric tep1 terf1 terf2 tert upregulated withdrawal	aneuploidy aplastic attrition circumstances complexly congenita constitutional cryptic delineated destabilize dyskeratosis enforcing etiologic helpful mucocutaneous multiorgan oncogenesis prominent recessive regenerative revision shelterin shorten stereotypical subtle telomere telomeropathy terc tert
Tagcloud (Difference) ?		anticancer catalytic cloned compensate division elucidated encoding erosion fusions generally homolog immortality length neoplasms p80 protection repeat repeats repressed ribonucleoprotein telomerase telomeric tep1 terf1 terf2 upregulated withdrawal	aneuploidy aplastic attrition circumstances complexly congenita constitutional cryptic delineated destabilize dyskeratosis enforcing etiologic helpful mucocutaneous multiorgan oncogenesis prominent recessive regenerative revision shelterin shorten stereotypical subtle telomeropathy
Tagcloud (Intersection) ?		telomere terc tert