DKC1 and LYPLA2

Number of citations of the paper that reports this interaction (PMID 16169070)
531

Data Source:
BioGRID (two hybrid)
HPRD (two hybrid)

		DKC1	LYPLA2
Gene Name		dyskeratosis congenita 1, dyskerin	lysophospholipase II
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleus Nucleoplasm Telomerase Holoenzyme Complex Nucleolus Cytoplasm Cajal Body	Cytoplasm Extracellular Vesicular Exosome
	Molecular Function	Telomerase Activity RNA Binding Protein Binding Pseudouridine Synthase Activity Poly(A) RNA Binding	Hydrolase Activity
	Biological Process	Telomere Maintenance Pseudouridine Synthesis RRNA Processing RNA Processing Telomere Maintenance Via Telomerase Cell Proliferation	Fatty Acid Metabolic Process
Pathways		Telomere Maintenance Chromosome Maintenance Extension of Telomeres Telomere Extension By Telomerase
Drugs
Diseases
GWAS
Protein-Protein Interactions		10 interactors: CSNK2A1 EEF1G EIF3F ERG LYPLA2 MAPK6 RUVBL1 SHQ1 SSR1 TERC	4 interactors: APP DKC1 MED31 SCMH1
Entrez ID		1736	11313
HPRD ID		02129	07127
Ensembl ID		ENSG00000130826	ENSG00000011009
Uniprot IDs		O60832	O95372 Q5QPQ2
PDB IDs
Enriched GO Terms of Interacting Partners?		Cellular Protein Metabolic Process Negative Regulation Of Potassium Ion Export Gene Expression Cellular Macromolecule Biosynthetic Process Macromolecule Biosynthetic Process Negative Regulation Of RRNA Processing Regulation Of Heart Rate By Hormone Protein Metabolic Process Cellular Macromolecular Complex Assembly Negative Regulation Of Ribosome Biogenesis Translation Ribonucleoprotein Complex Assembly	Synaptic Growth At Neuromuscular Junction RNA Metabolic Process Gene Expression Collateral Sprouting In Absence Of Injury Collateral Sprouting Axon Midline Choice Point Recognition Smooth Endoplasmic Reticulum Calcium Ion Homeostasis Axon Choice Point Recognition Nucleobase-containing Compound Metabolic Process Neuron Remodeling Telomere Maintenance Via Telomerase Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Cellular Nitrogen Compound Metabolic Process Nitrogen Compound Metabolic Process Cellular Copper Ion Homeostasis RNA Processing RNA-dependent DNA Replication Copper Ion Homeostasis Suckling Behavior Positive Regulation Of G2/M Transition Of Mitotic Cell Cycle Neuron Maturation MRNA Polyadenylation Regulation Of Epidermal Growth Factor-activated Receptor Activity Telomere Maintenance Via Telomere Lengthening Mating Behavior Endoplasmic Reticulum Calcium Ion Homeostasis Negative Regulation Of Fibroblast Proliferation RNA Polyadenylation Neuron Recognition Sexual Reproduction Pseudouridine Synthesis Nucleotide-binding Domain, Leucine Rich Repeat Containing Receptor Signaling Pathway
Tagcloud ?		aneuploidy aplastic attrition circumstances complexly congenita constitutional cryptic delineated destabilize dyskeratosis enforcing etiologic helpful mucocutaneous multiorgan oncogenesis prominent recessive regenerative revision shelterin shorten stereotypical subtle telomere telomeropathy terc tert	abpp advance campaign carbamate depalmitoylation dual fluopol hras hts irreversible micromolar ml211 ml348 ml349 ml378 optimized owing palmitoyl palmitoylation polarization sar scaffold seeking solubility thioesterase triazole
Tagcloud (Difference) ?		aneuploidy aplastic attrition circumstances complexly congenita constitutional cryptic delineated destabilize dyskeratosis enforcing etiologic helpful mucocutaneous multiorgan oncogenesis prominent recessive regenerative revision shelterin shorten stereotypical subtle telomere telomeropathy terc tert	abpp advance campaign carbamate depalmitoylation dual fluopol hras hts irreversible micromolar ml211 ml348 ml349 ml378 optimized owing palmitoyl palmitoylation polarization sar scaffold seeking solubility thioesterase triazole
Tagcloud (Intersection) ?