DKC1 and RUVBL1

Number of citations of the paper that reports this interaction (PMID 18358808)
59

Data Source:
HPRD (in vivo)

		DKC1	RUVBL1
Gene Name		dyskeratosis congenita 1, dyskerin	RuvB-like AAA ATPase 1
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleus Nucleoplasm Telomerase Holoenzyme Complex Nucleolus Cytoplasm Cajal Body	Swr1 Complex Nucleus Nucleoplasm Cytoplasm Golgi Apparatus Microtubule Organizing Center Membrane Nuclear Matrix Ino80 Complex NuA4 Histone Acetyltransferase Complex Intracellular Membrane-bounded Organelle Extracellular Vesicular Exosome MLL1 Complex
	Molecular Function	Telomerase Activity RNA Binding Protein Binding Pseudouridine Synthase Activity Poly(A) RNA Binding	DNA Helicase Activity Protein Binding ATP Binding ATPase Activity
	Biological Process	Telomere Maintenance Pseudouridine Synthesis RRNA Processing RNA Processing Telomere Maintenance Via Telomerase Cell Proliferation	DNA Repair DNA Recombination Chromatin Organization Nucleosome Assembly Transcription, DNA-templated Regulation Of Transcription From RNA Polymerase II Promoter Mitotic Nuclear Division Spermatogenesis DNA Duplex Unwinding CENP-A Containing Nucleosome Assembly Regulation Of Growth Histone H4 Acetylation Histone H2A Acetylation Cell Division
Pathways		Telomere Maintenance Chromosome Maintenance Extension of Telomeres Telomere Extension By Telomerase	Chromosome Maintenance Chromatin organization misspliced LRP5 mutants have enhanced beta-catenin-dependent signaling formation of the beta-catenin:TCF transactivating complex Deposition of new CENPA-containing nucleosomes at the centromere Telomere Extension By Telomerase Extension of Telomeres Signaling by Wnt HATs acetylate histones Chromatin modifying enzymes Telomere Maintenance Nucleosome assembly TCF dependent signaling in response to WNT RNF mutants show enhanced WNT signaling and proliferation XAV939 inhibits tankyrase, stabilizing AXIN Signaling by WNT in cancer
Drugs
Diseases
GWAS
Protein-Protein Interactions		10 interactors: CSNK2A1 EEF1G EIF3F ERG LYPLA2 MAPK6 RUVBL1 SHQ1 SSR1 TERC	20 interactors: ACTL6A CTNNB1 DKC1 FBL HDAC1 KIAA1377 LZTR1 MRGBP MYC NEDD4 NUFIP1 OFD1 PIH1D1 PLG RUVBL2 STOM TAF9 TBP TERT TK1
Entrez ID		1736	8607
HPRD ID		02129	09143
Ensembl ID		ENSG00000130826	ENSG00000175792
Uniprot IDs		O60832	Q9Y265
PDB IDs			2C9O 2XSZ
Enriched GO Terms of Interacting Partners?		Cellular Protein Metabolic Process Negative Regulation Of Potassium Ion Export Gene Expression Cellular Macromolecule Biosynthetic Process Macromolecule Biosynthetic Process Negative Regulation Of RRNA Processing Regulation Of Heart Rate By Hormone Protein Metabolic Process Cellular Macromolecular Complex Assembly Negative Regulation Of Ribosome Biogenesis Translation Ribonucleoprotein Complex Assembly	Chromatin Modification Chromosome Organization Chromatin Organization Organelle Organization RNA Metabolic Process Box C/D SnoRNP Assembly Nucleobase-containing Compound Metabolic Process Transcription Initiation From RNA Polymerase II Promoter Histone Modification Chromatin Remodeling Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Negative Regulation Of Signal Transduction Positive Regulation Of Gene Expression Cellular Response To UV Cellular Nitrogen Compound Metabolic Process Fungiform Papilla Formation Gene Expression Negative Regulation Of Signaling Telomere Maintenance Via Telomerase DNA-templated Transcription, Initiation Fungiform Papilla Morphogenesis Cellular Macromolecule Biosynthetic Process Regulation Of RNA Metabolic Process Macromolecule Biosynthetic Process Fungiform Papilla Development RNA Biosynthetic Process Positive Regulation Of Transcription, DNA-templated Regulation Of Transcription From RNA Polymerase II Promoter Cellular Response To Light Stimulus Developmental Process Nitrogen Compound Metabolic Process Histone H2A Acetylation Hair Follicle Placode Formation Cellular Component Assembly Tongue Morphogenesis DNA Biosynthetic Process Histone Acetylation Regulation Of Gene Expression Ribonucleoprotein Complex Biogenesis Internal Peptidyl-lysine Acetylation Positive Regulation Of Macromolecule Biosynthetic Process Regulation Of Nitrogen Compound Metabolic Process Positive Regulation Of Transcription From RNA Polymerase II Promoter Peptidyl-lysine Acetylation Internal Protein Amino Acid Acetylation RNA-dependent DNA Replication Protein Acetylation Response To UV Regulation Of Transcription, DNA-templated
Tagcloud ?		aneuploidy aplastic attrition circumstances complexly congenita constitutional cryptic delineated destabilize dyskeratosis enforcing etiologic helpful mucocutaneous multiorgan oncogenesis prominent recessive regenerative revision shelterin shorten stereotypical subtle telomere telomeropathy terc tert	anaemia aplastic assemble atpases conditional confers core crosslinker crosslinks depletion encode fa fanconi haematopoietic hallmark instability interstrand lethal monoubiquitin multisubunit pool profound purify repairs senses stringent surprisingly vertebrate
Tagcloud (Difference) ?		aneuploidy attrition circumstances complexly congenita constitutional cryptic delineated destabilize dyskeratosis enforcing etiologic helpful mucocutaneous multiorgan oncogenesis prominent recessive regenerative revision shelterin shorten stereotypical subtle telomere telomeropathy terc tert	anaemia assemble atpases conditional confers core crosslinker crosslinks depletion encode fa fanconi haematopoietic hallmark instability interstrand lethal monoubiquitin multisubunit pool profound purify repairs senses stringent surprisingly vertebrate
Tagcloud (Intersection) ?		aplastic