SPP1 and HMGN1

Number of citations of the paper that reports this interaction (PMID 22779921)
1

Data Source:
BioGRID (two hybrid)

		SPP1	HMGN1
Gene Name		secreted phosphoprotein 1	high mobility group nucleosome binding domain 1
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Extracellular Region Extracellular Space Cell Projection Apical Part Of Cell Perinuclear Region Of Cytoplasm Extracellular Vesicular Exosome	Chromatin Nucleus Cytoplasm
	Molecular Function	Cytokine Activity Protein Binding Extracellular Matrix Binding	DNA Binding Nucleosomal DNA Binding
	Biological Process	Osteoblast Differentiation Inflammatory Response Cell Adhesion Embryo Implantation Positive Regulation Of Cell-substrate Adhesion Extracellular Matrix Disassembly Extracellular Matrix Organization Neutrophil Chemotaxis Biomineral Tissue Development Response To Vitamin D Positive Regulation Of Bone Resorption Decidualization Response To Steroid Hormone Negative Regulation Of Collateral Sprouting Of Intact Axon In Response To Injury	Pyrimidine Dimer Repair By Nucleotide-excision Repair Transcription-coupled Nucleotide-excision Repair Chromatin Organization Regulation Of Transcription From RNA Polymerase II Promoter Response To UV-B Response To UV-C Positive Regulation Of DNA-templated Transcription, Elongation Regulation Of Development, Heterochronic Post-embryonic Camera-type Eye Morphogenesis Regulation Of Epithelial Cell Proliferation
Pathways		Signaling by PDGF Integrin cell surface interactions Degradation of the extracellular matrix
Drugs
Diseases
GWAS		Dental caries ( 23064961)
Protein-Protein Interactions		88 interactors: ABCF3 ACP5 AFF4 AMOTL2 APOA1 ATP2A2 ATP5F1 BAG6 BRD3 C1RL C2orf50 CACNG4 CALM1 CC2D1B CD44 CEP162 CHD1 CISD2 CMTM3 COMMD1 COPS5 CSNK2A1 CSNK2A2 CTNNBL1 CYB5R3 DCX DNAJB1 DNTTIP2 DSEL EEF1A1 EIF3K EPAS1 F2 FTH1 GRIPAP1 HBA2 HMGN1 IGFBP5 ITGA5 ITGA9 ITGAV ITGB1 KCNIP1 LRRC4 MAP1A MAP1B MARCKS MEOX2 MMP3 MMP7 MPPED1 MRPL23 NACA NCKAP1 NCSTN PDLIM7 PEMT PEPD PLD3 PRKACB PRKCA PRKG1 RANBP9 RAPGEF2 RBBP6 RIMS4 RPL13 RPL15 RPL5 RPS13 SEC24C SGTA SLC39A6 SNAPIN SSB STAU1 STK39 TBC1D8 TMEM168 TMEM30A TPT1 TTC1 TUBB UBQLN4 USP42 USP8 ZNF638 ZNF804A	17 interactors: BTG2 EP300 HMGN2 IRF2 LIG4 NFE2 PPP1CC PRKACA PRKACG PRKCA RPS6KA3 RPS6KA4 RPS6KA5 SLC38A3 SPP1 TERF2 YWHAZ
Entrez ID		6696	3150
HPRD ID		01325	01231
Ensembl ID		ENSG00000118785	ENSG00000205581
Uniprot IDs		B7Z351 P10451 Q3LGB0	A6NGZ2 P05114 Q6NSG7
PDB IDs		3CXD 3DSF
Enriched GO Terms of Interacting Partners?		Wound Healing Blood Coagulation Hemostasis Movement Of Cell Or Subcellular Component Neuron Projection Development Response To Wounding Chemotaxis Locomotion Membrane Organization Cell Projection Organization Axon Development Neuron Development Developmental Process Regulation Of Body Fluid Levels Cellular Localization Extracellular Matrix Organization Regulation Of Proteasomal Protein Catabolic Process Extracellular Structure Organization Chemical Homeostasis Anatomical Structure Development Axon Guidance Axonogenesis System Development Leukocyte Migration Translational Initiation Viral Process Ion Homeostasis Regulation Of Cellular Process Nervous System Development Multicellular Organismal Development Cell Migration Neuron Differentiation Metal Ion Homeostasis Cell Morphogenesis Involved In Neuron Differentiation Translational Elongation Immune System Process Integrin-mediated Signaling Pathway Viral Life Cycle Anatomical Structure Morphogenesis Cell Motility Homeostatic Process Neuron Projection Morphogenesis Heterotypic Cell-cell Adhesion Response To Stress Generation Of Neurons Regulation Of Cellular Protein Metabolic Process Catabolic Process Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Cell Development Regulation Of Protein Metabolic Process	Response To Stress Defense Response Histone Phosphorylation Immune Response Response To Stimulus Response To Organic Substance Positive Regulation Of Cellular Metabolic Process Chromosome Organization Immune System Process Chromatin Organization Positive Regulation Of Cellular Biosynthetic Process Blood Coagulation Neurotrophin TRK Receptor Signaling Pathway Hemostasis Neurotrophin Signaling Pathway Response To Interleukin-1 Triglyceride Catabolic Process Positive Regulation Of Dense Core Granule Biogenesis Innate Immune Response Positive Regulation Of Peptidyl-lysine Acetylation Positive Regulation Of Protein Acetylation Acylglycerol Catabolic Process Cellular Response To Organic Substance Peptidyl-serine Phosphorylation Cellular Response To Stimulus Positive Regulation Of Metabolic Process Regulation Of Cellular Protein Metabolic Process Histone H3-T6 Phosphorylation Regulation Of Body Fluid Levels Cellular Response To Growth Factor Stimulus Wound Healing Response To Growth Factor Chemotaxis Chromatin Modification Energy Reserve Metabolic Process Histone H3-S10 Phosphorylation Regulation Of Protein Metabolic Process Multicellular Organismal Development Epidermal Growth Factor Receptor Signaling Pathway Positive Regulation Of Histone Phosphorylation Response To Wounding ERBB Signaling Pathway Histone Modification Anatomical Structure Development Regulation Of Cellular Amino Acid Metabolic Process Activation Of Phospholipase C Activity Neutrophil Chemotaxis Neutrophil Migration Intrinsic Apoptotic Signaling Pathway Positive Regulation Of Phospholipase C Activity
Tagcloud ?		able acquisition acts carcinomas cbx7 chemokine contributing counteracts decreases encoding fact hmga1b inducing interacting interferes involves malignant member modulation osteopontin played polycomb progressively relation repressive suppose take transcriptional whose	bioactivities characterize count downregulated exerts gfp healing hmgn2 hmgn5 hmgns infect ki lentivirus markedly migration mobility nude os osteosarcoma pcna recombinant relatively relevance remain sao2 subcutaneous u2 volumes wound
Tagcloud (Difference) ?		able acquisition acts carcinomas cbx7 chemokine contributing counteracts decreases encoding fact hmga1b inducing interacting interferes involves malignant member modulation osteopontin played polycomb progressively relation repressive suppose take transcriptional whose	bioactivities characterize count downregulated exerts gfp healing hmgn2 hmgn5 hmgns infect ki lentivirus markedly migration mobility nude os osteosarcoma pcna recombinant relatively relevance remain sao2 subcutaneous u2 volumes wound
Tagcloud (Intersection) ?