HMGN1 and TERF2

Number of citations of the paper that reports this interaction (PMID 21044950)
9

Data Source:
BioGRID (two hybrid)

		HMGN1	TERF2
Gene Name		high mobility group nucleosome binding domain 1	telomeric repeat binding factor 2
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Chromatin Nucleus Cytoplasm	Chromosome, Telomeric Region Nuclear Telomere Cap Complex Nuclear Chromosome, Telomeric Region Male Germ Cell Nucleus Nucleus Nucleoplasm Cytoplasm Golgi Apparatus Mre11 Complex
	Molecular Function	DNA Binding Nucleosomal DNA Binding	Chromatin Binding Double-stranded Telomeric DNA Binding Protein Binding Protein C-terminus Binding Telomeric DNA Binding Protein Homodimerization Activity
	Biological Process	Pyrimidine Dimer Repair By Nucleotide-excision Repair Transcription-coupled Nucleotide-excision Repair Chromatin Organization Regulation Of Transcription From RNA Polymerase II Promoter Response To UV-B Response To UV-C Positive Regulation Of DNA-templated Transcription, Elongation Regulation Of Development, Heterochronic Post-embryonic Camera-type Eye Morphogenesis Regulation Of Epithelial Cell Proliferation	Telomere Maintenance Age-dependent Telomere Shortening In Utero Embryonic Development Telomere Maintenance Via Telomerase Cell Cycle Telomere Capping Telomeric Loop Formation Protection From Non-homologous End Joining At Telomere Negative Regulation Of Telomere Maintenance Positive Regulation Of Telomere Maintenance Negative Regulation Of Telomere Maintenance Via Semi-conservative Replication Protein Localization To Chromosome, Telomeric Region Cellular Senescence
Pathways			Telomere Maintenance Packaging Of Telomere Ends DNA Damage/Telomere Stress Induced Senescence Chromosome Maintenance Cellular Senescence Meiotic synapsis
Drugs
Diseases
GWAS
Protein-Protein Interactions		17 interactors: BTG2 EP300 HMGN2 IRF2 LIG4 NFE2 PPP1CC PRKACA PRKACG PRKCA RPS6KA3 RPS6KA4 RPS6KA5 SLC38A3 SPP1 TERF2 YWHAZ	55 interactors: AFAP1L2 ANXA5 APEX1 ASS1 ATM BANP BLM CCDC137 CTBP1 DCLRE1B DDX21 DDX24 DDX39A EP300 GNMT H2AFX HDGFRP2 HEXIM1 HEXIM2 HMGB1 HMGN1 HMGN2 HMGN3 HMGN4 LANCL2 LYAR MAGOHB NAIF1 NASP NCL NUMA1 NXNL1 OCM2 ORC3 ORC6 POT1 PPM1G PRMT1 PTMA RNF113A RPL13 RPRD1B SET SIAH1 SP100 SRSF6 TALDO1 TERF2IP TINF2 TMSB10 TOR1AIP1 WDR4 WRN XRCC6 ZC3H18
Entrez ID		3150	7014
HPRD ID		01231	03610
Ensembl ID		ENSG00000205581	ENSG00000132604
Uniprot IDs		A6NGZ2 P05114 Q6NSG7	Q15554
PDB IDs			1H6P 1VF9 1VFC 1W0U 1XG1 3BU8 3BUA 3K6G 3SJM 4M7C
Enriched GO Terms of Interacting Partners?		Response To Stress Defense Response Histone Phosphorylation Immune Response Response To Stimulus Response To Organic Substance Positive Regulation Of Cellular Metabolic Process Chromosome Organization Immune System Process Chromatin Organization Positive Regulation Of Cellular Biosynthetic Process Blood Coagulation Neurotrophin TRK Receptor Signaling Pathway Hemostasis Neurotrophin Signaling Pathway Response To Interleukin-1 Triglyceride Catabolic Process Positive Regulation Of Dense Core Granule Biogenesis Innate Immune Response Positive Regulation Of Peptidyl-lysine Acetylation Positive Regulation Of Protein Acetylation Acylglycerol Catabolic Process Cellular Response To Organic Substance Peptidyl-serine Phosphorylation Cellular Response To Stimulus Positive Regulation Of Metabolic Process Regulation Of Cellular Protein Metabolic Process Histone H3-T6 Phosphorylation Regulation Of Body Fluid Levels Cellular Response To Growth Factor Stimulus Wound Healing Response To Growth Factor Chemotaxis Chromatin Modification Energy Reserve Metabolic Process Histone H3-S10 Phosphorylation Regulation Of Protein Metabolic Process Multicellular Organismal Development Epidermal Growth Factor Receptor Signaling Pathway Positive Regulation Of Histone Phosphorylation Response To Wounding ERBB Signaling Pathway Histone Modification Anatomical Structure Development Regulation Of Cellular Amino Acid Metabolic Process Activation Of Phospholipase C Activity Neutrophil Chemotaxis Neutrophil Migration Intrinsic Apoptotic Signaling Pathway Positive Regulation Of Phospholipase C Activity	Telomere Maintenance Chromosome Organization Nucleobase-containing Compound Metabolic Process Cellular Nitrogen Compound Metabolic Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Nitrogen Compound Metabolic Process DNA Metabolic Process Organelle Organization DNA Replication Chromatin Organization Negative Regulation Of Chromosome Organization Cellular Response To DNA Damage Stimulus DNA Conformation Change Telomere Capping Cell Cycle Cellular Metabolic Process DNA Recombination Telomere Maintenance Via Telomere Lengthening Double-strand Break Repair Negative Regulation Of Telomere Maintenance RNA Metabolic Process Negative Regulation Of Biosynthetic Process Negative Regulation Of Cellular Metabolic Process Cellular Macromolecule Biosynthetic Process DNA Repair Chromatin Modification Macromolecule Biosynthetic Process Biosynthetic Process Regulation Of Chromosome Organization Cellular Response To Stress Cellular Response To Ionizing Radiation Regulation Of Telomere Maintenance Response To Ionizing Radiation Regulation Of Cell Cycle DNA Duplex Unwinding DNA Geometric Change Regulation Of Nitrogen Compound Metabolic Process Double-strand Break Repair Via Homologous Recombination V(D)J Recombination Recombinational Repair Regulation Of Metabolic Process Cell Cycle Process Protection From Non-homologous End Joining At Telomere Negative Regulation Of DNA Metabolic Process Homeostatic Process Negative Regulation Of Nucleic Acid-templated Transcription Gene Expression Protein Localization To Chromosome, Telomeric Region Negative Regulation Of Telomere Maintenance Via Telomerase
Tagcloud ?		bioactivities characterize count downregulated exerts gfp healing hmgn2 hmgn5 hmgns infect ki lentivirus markedly migration mobility nude os osteosarcoma pcna recombinant relatively relevance remain sao2 subcutaneous u2 volumes wound	anticancer catalytic cloned compensate division elucidated encoding erosion fusions generally homolog immortality length neoplasms p80 protection repeat repeats repressed ribonucleoprotein telomerase telomere telomeric tep1 terc terf1 tert upregulated withdrawal
Tagcloud (Difference) ?		bioactivities characterize count downregulated exerts gfp healing hmgn2 hmgn5 hmgns infect ki lentivirus markedly migration mobility nude os osteosarcoma pcna recombinant relatively relevance remain sao2 subcutaneous u2 volumes wound	anticancer catalytic cloned compensate division elucidated encoding erosion fusions generally homolog immortality length neoplasms p80 protection repeat repeats repressed ribonucleoprotein telomerase telomere telomeric tep1 terc terf1 tert upregulated withdrawal
Tagcloud (Intersection) ?