SPP1 and LRRC4

Number of citations of the paper that reports this interaction (PMID 22779921)
1

Data Source:
BioGRID (two hybrid)

		SPP1	LRRC4
Gene Name		secreted phosphoprotein 1	leucine rich repeat containing 4
Image
Gene Ontology Annotations	Cellular Component	Extracellular Region Extracellular Space Cell Projection Apical Part Of Cell Perinuclear Region Of Cytoplasm Extracellular Vesicular Exosome	Integral Component Of Membrane Cell Junction Dendritic Spine Postsynaptic Membrane Excitatory Synapse
	Molecular Function	Cytokine Activity Protein Binding Extracellular Matrix Binding	Protein Binding
	Biological Process	Osteoblast Differentiation Inflammatory Response Cell Adhesion Embryo Implantation Positive Regulation Of Cell-substrate Adhesion Extracellular Matrix Disassembly Extracellular Matrix Organization Neutrophil Chemotaxis Biomineral Tissue Development Response To Vitamin D Positive Regulation Of Bone Resorption Decidualization Response To Steroid Hormone Negative Regulation Of Collateral Sprouting Of Intact Axon In Response To Injury	Regulation Of Synapse Organization Synapse Organization Postsynaptic Density Protein 95 Clustering
Pathways		Signaling by PDGF Integrin cell surface interactions Degradation of the extracellular matrix
Drugs
Diseases
GWAS		Dental caries ( 23064961)
Protein-Protein Interactions		88 interactors: ABCF3 ACP5 AFF4 AMOTL2 APOA1 ATP2A2 ATP5F1 BAG6 BRD3 C1RL C2orf50 CACNG4 CALM1 CC2D1B CD44 CEP162 CHD1 CISD2 CMTM3 COMMD1 COPS5 CSNK2A1 CSNK2A2 CTNNBL1 CYB5R3 DCX DNAJB1 DNTTIP2 DSEL EEF1A1 EIF3K EPAS1 F2 FTH1 GRIPAP1 HBA2 HMGN1 IGFBP5 ITGA5 ITGA9 ITGAV ITGB1 KCNIP1 LRRC4 MAP1A MAP1B MARCKS MEOX2 MMP3 MMP7 MPPED1 MRPL23 NACA NCKAP1 NCSTN PDLIM7 PEMT PEPD PLD3 PRKACB PRKCA PRKG1 RANBP9 RAPGEF2 RBBP6 RIMS4 RPL13 RPL15 RPL5 RPS13 SEC24C SGTA SLC39A6 SNAPIN SSB STAU1 STK39 TBC1D8 TMEM168 TMEM30A TPT1 TTC1 TUBB UBQLN4 USP42 USP8 ZNF638 ZNF804A	1 interactors: SPP1
Entrez ID		6696	64101
HPRD ID		01325	10060
Ensembl ID		ENSG00000118785	ENSG00000128594
Uniprot IDs		B7Z351 P10451 Q3LGB0	Q9HBW1
PDB IDs		3CXD 3DSF	2DL9 3ZYI
Enriched GO Terms of Interacting Partners?		Wound Healing Blood Coagulation Hemostasis Movement Of Cell Or Subcellular Component Neuron Projection Development Response To Wounding Chemotaxis Locomotion Membrane Organization Cell Projection Organization Axon Development Neuron Development Developmental Process Regulation Of Body Fluid Levels Cellular Localization Extracellular Matrix Organization Regulation Of Proteasomal Protein Catabolic Process Extracellular Structure Organization Chemical Homeostasis Anatomical Structure Development Axon Guidance Axonogenesis System Development Leukocyte Migration Translational Initiation Viral Process Ion Homeostasis Regulation Of Cellular Process Nervous System Development Multicellular Organismal Development Cell Migration Neuron Differentiation Metal Ion Homeostasis Cell Morphogenesis Involved In Neuron Differentiation Translational Elongation Immune System Process Integrin-mediated Signaling Pathway Viral Life Cycle Anatomical Structure Morphogenesis Cell Motility Homeostatic Process Neuron Projection Morphogenesis Heterotypic Cell-cell Adhesion Response To Stress Generation Of Neurons Regulation Of Cellular Protein Metabolic Process Catabolic Process Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Cell Development Regulation Of Protein Metabolic Process	Negative Regulation Of Collateral Sprouting Of Intact Axon In Response To Injury Regulation Of Collateral Sprouting Of Intact Axon In Response To Injury Negative Regulation Of Collateral Sprouting Negative Regulation Of Axon Regeneration Positive Regulation Of Bone Resorption Regulation Of Axon Regeneration Positive Regulation Of Tissue Remodeling Response To Vitamin D Decidualization Regulation Of Bone Resorption Maternal Placenta Development Regulation Of Bone Remodeling Neutrophil Chemotaxis Neutrophil Migration Granulocyte Chemotaxis Negative Regulation Of Axonogenesis Regulation Of Tissue Remodeling Biomineral Tissue Development Embryo Implantation Maternal Process Involved In Female Pregnancy Negative Regulation Of Developmental Growth Extracellular Matrix Disassembly Negative Regulation Of Cell Morphogenesis Involved In Differentiation Leukocyte Chemotaxis Response To Vitamin Negative Regulation Of Neuron Projection Development Positive Regulation Of Cell-substrate Adhesion Regulation Of Cell Size Osteoblast Differentiation Negative Regulation Of Cell Projection Organization Negative Regulation Of Cell Growth Regulation Of Axonogenesis Cell Chemotaxis Negative Regulation Of Neuron Differentiation Placenta Development Regulation Of Cell-substrate Adhesion Response To Nutrient Leukocyte Migration Female Pregnancy Negative Regulation Of Growth Ossification Regulation Of Developmental Growth Negative Regulation Of Neurogenesis Regulation Of Cellular Component Size Negative Regulation Of Cell Development Regulation Of Cell Growth Extracellular Matrix Organization Extracellular Structure Organization Positive Regulation Of Cell Adhesion Regulation Of Neuron Projection Development
Tagcloud ?		able acquisition acts carcinomas cbx7 chemokine contributing counteracts decreases encoding fact hmga1b inducing interacting interferes involves malignant member modulation osteopontin played polycomb progressively relation repressive suppose take transcriptional whose	angiogenesis belongs complicated dendritic glioma gliomas lamina leucine ligand loops member mirna modification multiphase nervous netrin networks neurite ngl outgrowth relatively repeat rich segmentation summary superfamily suppresses tumorigenesis
Tagcloud (Difference) ?		able acquisition acts carcinomas cbx7 chemokine contributing counteracts decreases encoding fact hmga1b inducing interacting interferes involves malignant modulation osteopontin played polycomb progressively relation repressive suppose take transcriptional whose	angiogenesis belongs complicated dendritic glioma gliomas lamina leucine ligand loops mirna modification multiphase nervous netrin networks neurite ngl outgrowth relatively repeat rich segmentation summary superfamily suppresses tumorigenesis
Tagcloud (Intersection) ?		member