SPP1 and PRKACB

Number of citations of the paper that reports this interaction (PMID 22779921)
1

Data Source:
BioGRID (two hybrid)

		SPP1	PRKACB
Gene Name		secreted phosphoprotein 1	protein kinase, cAMP-dependent, catalytic, beta
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Extracellular Region Extracellular Space Cell Projection Apical Part Of Cell Perinuclear Region Of Cytoplasm Extracellular Vesicular Exosome	Nucleoplasm Centrosome Cytosol Plasma Membrane CAMP-dependent Protein Kinase Complex Perinuclear Region Of Cytoplasm Extracellular Vesicular Exosome Ciliary Base
	Molecular Function	Cytokine Activity Protein Binding Extracellular Matrix Binding	Magnesium Ion Binding CAMP-dependent Protein Kinase Activity Protein Binding ATP Binding Ubiquitin Protein Ligase Binding
	Biological Process	Osteoblast Differentiation Inflammatory Response Cell Adhesion Embryo Implantation Positive Regulation Of Cell-substrate Adhesion Extracellular Matrix Disassembly Extracellular Matrix Organization Neutrophil Chemotaxis Biomineral Tissue Development Response To Vitamin D Positive Regulation Of Bone Resorption Decidualization Response To Steroid Hormone Negative Regulation Of Collateral Sprouting Of Intact Axon In Response To Injury	Neural Tube Closure Renal Water Homeostasis Carbohydrate Metabolic Process Glucose Metabolic Process Gluconeogenesis Energy Reserve Metabolic Process Protein Phosphorylation Water Transport Signal Transduction Epidermal Growth Factor Receptor Signaling Pathway Adenylate Cyclase-modulating G-protein Coupled Receptor Signaling Pathway Activation Of Phospholipase C Activity Synaptic Transmission Blood Coagulation Fibroblast Growth Factor Receptor Signaling Pathway Pathogenesis Triglyceride Catabolic Process Activation Of Protein Kinase A Activity Intracellular Signal Transduction Small Molecule Metabolic Process Innate Immune Response Neurotrophin TRK Receptor Signaling Pathway Regulation Of Insulin Secretion Negative Regulation Of Meiotic Cell Cycle Transmembrane Transport Regulation Of Protein Processing Cellular Response To Glucagon Stimulus Response To Clozapine Negative Regulation Of Smoothened Signaling Pathway Involved In Dorsal/ventral Neural Tube Patterning
Pathways		Signaling by PDGF Integrin cell surface interactions Degradation of the extracellular matrix	Signaling by GPCR Ca-dependent events CaM pathway Glucagon-like Peptide-1 (GLP1) regulates insulin secretion Metabolism of lipids and lipoproteins Integration of energy metabolism Hedgehog 'off' state Phospholipase C-mediated cascade Signaling by FGFR in disease Signaling by EGFRvIII in Cancer PLCG1 events in ERBB2 signaling Gluconeogenesis Glucose metabolism DAP12 signaling Rap1 signalling Myoclonic epilepsy of Lafora Hormone-sensitive lipase (HSL)-mediated triacylglycerol hydrolysis Glycogen storage diseases PKA-mediated phosphorylation of key metabolic factors Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic Cell Glucagon signaling in metabolic regulation Signaling by PDGF Calmodulin induced events DAP12 interactions PKA-mediated phosphorylation of CREB Opioid Signalling PKA activation Aquaporin-mediated transport Factors involved in megakaryocyte development and platelet production CREB phosphorylation through the activation of Adenylate Cyclase EGFR interacts with phospholipase C-gamma Signaling by ERBB2 Signaling by EGFR PKA-mediated phosphorylation of CREB Signaling by VEGF Downstream signal transduction Calmodulin induced events Signaling by EGFR in Cancer PKA activation Metabolism of carbohydrates Transmission across Chemical Synapses Adaptive Immune System VEGFA-VEGFR2 Pathway DAG and IP3 signaling CaM pathway Activation of NMDA receptor upon glutamate binding and postsynaptic events Downstream signaling of activated FGFR DARPP-32 events Post NMDA receptor activation events Innate Immune System PKA activation in glucagon signalling Signalling by NGF PLC beta mediated events Vasopressin regulates renal water homeostasis via Aquaporins Regulation of insulin secretion Signaling by Ligand-Responsive EGFR Variants in Cancer Lipid digestion, mobilization, and transport NGF signalling via TRKA from the plasma membrane G-protein mediated events Signaling by Overexpressed Wild-Type EGFR in Cancer Signaling by FGFR PLC-gamma1 signalling Signaling by Hedgehog Degradation of GLI1 by the proteasome GLI3 is processed to GLI3R by the proteasome Degradation of GLI2 by the proteasome
Drugs
Diseases
GWAS		Dental caries ( 23064961)	Breast cancer (male) ( 23001122)
Protein-Protein Interactions		88 interactors: ABCF3 ACP5 AFF4 AMOTL2 APOA1 ATP2A2 ATP5F1 BAG6 BRD3 C1RL C2orf50 CACNG4 CALM1 CC2D1B CD44 CEP162 CHD1 CISD2 CMTM3 COMMD1 COPS5 CSNK2A1 CSNK2A2 CTNNBL1 CYB5R3 DCX DNAJB1 DNTTIP2 DSEL EEF1A1 EIF3K EPAS1 F2 FTH1 GRIPAP1 HBA2 HMGN1 IGFBP5 ITGA5 ITGA9 ITGAV ITGB1 KCNIP1 LRRC4 MAP1A MAP1B MARCKS MEOX2 MMP3 MMP7 MPPED1 MRPL23 NACA NCKAP1 NCSTN PDLIM7 PEMT PEPD PLD3 PRKACB PRKCA PRKG1 RANBP9 RAPGEF2 RBBP6 RIMS4 RPL13 RPL15 RPL5 RPS13 SEC24C SGTA SLC39A6 SNAPIN SSB STAU1 STK39 TBC1D8 TMEM168 TMEM30A TPT1 TTC1 TUBB UBQLN4 USP42 USP8 ZNF638 ZNF804A	12 interactors: ACVR1B APPBP2 ARFGAP1 CSNK2A1 NGFR PKIA PKIB RPL27A RPS6 SPP1 TNP1 TNP2
Entrez ID		6696	5567
HPRD ID		01325	01482
Ensembl ID		ENSG00000118785	ENSG00000142875
Uniprot IDs		B7Z351 P10451 Q3LGB0	B1APF9 B1APG3 B2RB89 B7ZA00 P22694
PDB IDs		3CXD 3DSF
Enriched GO Terms of Interacting Partners?		Wound Healing Blood Coagulation Hemostasis Movement Of Cell Or Subcellular Component Neuron Projection Development Response To Wounding Chemotaxis Locomotion Membrane Organization Cell Projection Organization Axon Development Neuron Development Developmental Process Regulation Of Body Fluid Levels Cellular Localization Extracellular Matrix Organization Regulation Of Proteasomal Protein Catabolic Process Extracellular Structure Organization Chemical Homeostasis Anatomical Structure Development Axon Guidance Axonogenesis System Development Leukocyte Migration Translational Initiation Viral Process Ion Homeostasis Regulation Of Cellular Process Nervous System Development Multicellular Organismal Development Cell Migration Neuron Differentiation Metal Ion Homeostasis Cell Morphogenesis Involved In Neuron Differentiation Translational Elongation Immune System Process Integrin-mediated Signaling Pathway Viral Life Cycle Anatomical Structure Morphogenesis Cell Motility Homeostatic Process Neuron Projection Morphogenesis Heterotypic Cell-cell Adhesion Response To Stress Generation Of Neurons Regulation Of Cellular Protein Metabolic Process Catabolic Process Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Cell Development Regulation Of Protein Metabolic Process	Negative Regulation Of CAMP-dependent Protein Kinase Activity Regulation Of CAMP-dependent Protein Kinase Activity Intracellular Protein Transport Protein Complex Disassembly Establishment Of Localization In Cell Locomotion Reproductive Process Cellular Protein Localization Developmental Process Involved In Reproduction Regulation Of Protein Metabolic Process Sperm Motility Protein Transport Negative Regulation Of Axonogenesis Establishment Of Protein Localization Movement Of Cell Or Subcellular Component Multicellular Organismal Reproductive Process Fertilization, Exchange Of Chromosomal Proteins Negative Regulation Of Collateral Sprouting Of Intact Axon In Response To Injury Intracellular Transport Cellular Localization Multicellular Organism Reproduction Regulation Of Cell Growth Regulation Of Cell Cycle Viral Transcription Regulation Of Mitotic Cell Cycle Hair Follicle Development Male Pronucleus Assembly Positive Regulation Of Trophoblast Cell Migration Regulation Of Collateral Sprouting Of Intact Axon In Response To Injury Apoptotic Process Nuclear-transcribed MRNA Catabolic Process, Nonsense-mediated Decay Hair Cycle Process SRP-dependent Cotranslational Protein Targeting To Membrane Cotranslational Protein Targeting To Membrane Protein Targeting To ER Negative Regulation Of Cell Morphogenesis Involved In Differentiation Programmed Cell Death Establishment Of Protein Localization To Endoplasmic Reticulum Negative Regulation Of Cell Cycle Hair Cycle Reproduction Cell Death Death Regulation Of Protein Phosphorylation Negative Regulation Of Hair Follicle Development Protein Localization Negative Regulation Of Neuron Projection Development Protein Localization To Endoplasmic Reticulum Regulation Of Cellular Protein Metabolic Process Single Fertilization
Tagcloud ?		able acquisition acts carcinomas cbx7 chemokine contributing counteracts decreases encoding fact hmga1b inducing interacting interferes involves malignant member modulation osteopontin played polycomb progressively relation repressive suppose take transcriptional whose	agouti albinism asip atf1 delta25 dopachrome edn1 edn3 ednrb exoc2 exocyst kitlg ludwigshafen mc1r microphthalmia oca2 oculocutaneous pigmentation prkar1a prkar2a proopiomelanocortin slc24a4 slc45a2 tautomerase tpcn2 tubb3 tyrp1
Tagcloud (Difference) ?		able acquisition acts carcinomas cbx7 chemokine contributing counteracts decreases encoding fact hmga1b inducing interacting interferes involves malignant member modulation osteopontin played polycomb progressively relation repressive suppose take transcriptional whose	agouti albinism asip atf1 delta25 dopachrome edn1 edn3 ednrb exoc2 exocyst kitlg ludwigshafen mc1r microphthalmia oca2 oculocutaneous pigmentation prkar1a prkar2a proopiomelanocortin slc24a4 slc45a2 tautomerase tpcn2 tubb3 tyrp1
Tagcloud (Intersection) ?