TSPYL2 and GFI1B

Number of citations of the paper that reports this interaction (PMID 16713569)
214

Data Source:
BioGRID (two hybrid)
HPRD (two hybrid)

		TSPYL2	GFI1B
Gene Name		TSPY-like 2	growth factor independent 1B transcription repressor
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleus Nucleoplasm Nucleolus Cytoplasm Centrosome Plasma Membrane	Nucleus Transcription Factor Complex Nuclear Matrix
	Molecular Function	RDNA Binding	RNA Polymerase II Transcription Factor Binding DNA Binding Protein Binding Metal Ion Binding
	Biological Process	Nucleosome Assembly Transcription, DNA-templated Regulation Of Transcription, DNA-templated Activation Of Signaling Protein Activity Involved In Unfolded Protein Response Cell Cycle Negative Regulation Of DNA Replication Regulation Of Signal Transduction Chromatin Modification Negative Regulation Of Cell Growth Endoplasmic Reticulum Unfolded Protein Response Cellular Protein Metabolic Process Negative Regulation Of Cell Cycle Regulation Of Protein Kinase Activity	Negative Regulation Of Transcription From RNA Polymerase II Promoter Transcription From RNA Polymerase II Promoter Cell Proliferation Chromatin Modification Hemopoiesis Regulation Of Histone H3-K4 Methylation
Pathways		IRE1alpha activates chaperones XBP1(S) activates chaperone genes Unfolded Protein Response (UPR)
Drugs
Diseases
GWAS
Protein-Protein Interactions		9 interactors: APTX CASK CCNB1 CDK1 CDK2 CDK4 COIL EEF1A1 GFI1B	71 interactors: ACTN1 AES AGPAT6 AGRN AJUBA ANKS3 ATXN2 BECN1 BEGAIN BEND5 BRCA1 BRE CCDC136 CCDC85B CENPB CENPJ COPS5 DNAJA3 DTNA DZANK1 EFEMP1 EFEMP2 EGFL7 FBLN1 FBLN5 GRIP2 GRN HECW1 HGS HNRNPK HSPG2 IFFO1 JAG2 KALRN KIF17 LAMB1 LTBP4 LZTS2 MATR3 MEGF6 MEGF8 MID2 MON1A MYH14 NELL1 NELL2 NOTCH1 NSMF PDE4DIP PDLIM5 PDZD4 PHC2 PICK1 PSMA3 RAB11FIP4 RCHY1 RINT1 RNF31 RUNDC3A TAF1 TMF1 TNS2 TRAF1 TRIM27 TRIP6 TSPYL2 TXNDC11 USHBP1 VSNL1 ZNRD1 ZNRF3
Entrez ID		64061	8328
HPRD ID		06713	05088
Ensembl ID		ENSG00000184205	ENSG00000165702
Uniprot IDs		Q9H2G4	Q5VTD9
PDB IDs
Enriched GO Terms of Interacting Partners?		G1/S Transition Of Mitotic Cell Cycle Response To Inorganic Substance Histone Phosphorylation Mitotic Cell Cycle Phase Transition Cell Cycle Phase Transition Regulation Of Ubiquitin-protein Ligase Activity Involved In Mitotic Cell Cycle Chromatin Organization Positive Regulation Of Cell Cycle Anaphase-promoting Complex-dependent Proteasomal Ubiquitin-dependent Protein Catabolic Process Regulation Of Ubiquitin-protein Transferase Activity Regulation Of Gene Expression Regulation Of Mitotic Cell Cycle Positive Regulation Of Mitotic Cell Cycle Cell Division G2/M Transition Of Mitotic Cell Cycle Chromosome Organization Ventricular Cardiac Muscle Cell Development Response To Toxic Substance Protein Phosphorylation Chromatin Modification Response To Reactive Oxygen Species Regulation Of Protein Ubiquitination Ventricular Cardiac Muscle Cell Differentiation Mitotic Cell Cycle Process Positive Regulation Of Cardiac Muscle Cell Proliferation Regulation Of Cell Proliferation Positive Regulation Of Gene Expression Mitotic Nuclear Envelope Disassembly Mitotic Cell Cycle Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Nucleobase-containing Compound Metabolic Process Proteasomal Protein Catabolic Process Positive Regulation Of Heart Growth Phosphate-containing Compound Metabolic Process Nuclear Envelope Disassembly Positive Regulation Of Cell Proliferation Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Regulation Of Cardiac Muscle Cell Proliferation Cellular Macromolecule Catabolic Process Regulation Of Metabolic Process Chromosome Condensation Positive Regulation Of Organ Growth Mitotic Nuclear Division Cellular Nitrogen Compound Metabolic Process Response To Metal Ion Phosphorylation Regulation Of Cell Cycle Centrosome Cycle Regulation Of Heart Growth	Regulation Of Cellular Process Cell Communication Regulation Of Cellular Component Organization Regulation Of Signaling Extracellular Matrix Organization Extracellular Structure Organization Signaling Cellular Response To Stimulus Signal Transduction Response To Stimulus Negative Regulation Of Canonical Wnt Signaling Pathway Regulation Of Signal Transduction Regulation Of Growth Negative Regulation Of Wnt Signaling Pathway Regulation Of Metabolic Process Multicellular Organismal Development Regulation Of Canonical Wnt Signaling Pathway Developmental Process Secretion Negative Regulation Of Signaling Regulation Of Locomotion Cellular Process Regulation Of Cellular Component Movement Focal Adhesion Assembly Protein Localization Protein Ubiquitination Cellular Localization Negative Regulation Of Signal Transduction Regulation Of Protein Metabolic Process Regulation Of Wnt Signaling Pathway Protein Modification By Small Protein Conjugation Cell Cycle Positive Regulation Of Cellular Metabolic Process Regulation Of Gene Expression, Epigenetic Cell-substrate Adhesion Adherens Junction Assembly Cell Differentiation Cellular Component Assembly Neurogenesis Auditory Receptor Cell Fate Commitment Anatomical Structure Development Regulation Of Gene Expression Regulation Of Proteolysis Regulation Of Apoptotic Process Cell-substrate Junction Assembly Regulation Of I-kappaB Kinase/NF-kappaB Signaling Secretion By Cell Regulation Of Cell Proliferation Receptor Clustering Regulation Of Vesicle-mediated Transport
Tagcloud ?		abolishes abrogates af1 bradyzoite bradyzoites cyst cysts disseminate gondii ip1 myoblasts myosin myotubes opportunistic persist polynucleated replicate replicating restrict skmcs sustain syncytial tachyzoite tachyzoites toxoplasma toxoplasmosis upregulate vigorous vigorously	appending competitively corepressor corest counteract demethylase demethylates demethylation derepression epigenetically erythro fates h3k4 lsd1 megakaryocytic nucleosomal opposes paralogs potentiate rcor rcor1 rcor2 rcor3 repressing restraining sant2 sharp upsurge
Tagcloud (Difference) ?		abolishes abrogates af1 bradyzoite bradyzoites cyst cysts disseminate gondii ip1 myoblasts myosin myotubes opportunistic persist polynucleated replicate replicating restrict skmcs sustain syncytial tachyzoite tachyzoites toxoplasma toxoplasmosis upregulate vigorous vigorously	appending competitively corepressor corest counteract demethylase demethylates demethylation derepression epigenetically erythro fates h3k4 lsd1 megakaryocytic nucleosomal opposes paralogs potentiate rcor rcor1 rcor2 rcor3 repressing restraining sant2 sharp upsurge
Tagcloud (Intersection) ?