RYR1 and PRKG1

Number of citations of the paper that reports this interaction (PMID 14532276)
37

Data Source:
HPRD (in vitro)

		RYR1	PRKG1
Gene Name		ryanodine receptor 1 (skeletal)	protein kinase, cGMP-dependent, type I
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Cytoplasm Smooth Endoplasmic Reticulum Plasma Membrane Integral Component Of Plasma Membrane Cell Cortex Junctional Sarcoplasmic Reticulum Membrane Terminal Cisterna Sarcoplasmic Reticulum Junctional Membrane Complex T-tubule I Band Sarcoplasmic Reticulum Membrane Extracellular Vesicular Exosome	Cytoplasm Golgi Apparatus Cytosol Plasma Membrane
	Molecular Function	Protease Binding Ryanodine-sensitive Calcium-release Channel Activity Voltage-gated Calcium Channel Activity Calcium Channel Activity Protein Binding Calmodulin Binding Calcium-release Channel Activity	CGMP-dependent Protein Kinase Activity Calcium Channel Regulator Activity Protein Binding ATP Binding CGMP Binding
	Biological Process	Response To Hypoxia Outflow Tract Morphogenesis Calcium Ion Transport Muscle Contraction Release Of Sequestered Calcium Ion Into Cytosol By Sarcoplasmic Reticulum Response To Caffeine Ion Transmembrane Transport Skin Development Ossification Involved In Bone Maturation Skeletal Muscle Fiber Development Release Of Sequestered Calcium Ion Into Cytosol Cytosolic Calcium Ion Homeostasis Transmembrane Transport Calcium Ion Transmembrane Transport Cellular Response To Caffeine	Neuron Migration Protein Phosphorylation Signal Transduction Blood Coagulation Dendrite Development CGMP-mediated Signaling Actin Cytoskeleton Organization Forebrain Development Regulation Of GTPase Activity Relaxation Of Vascular Smooth Muscle Negative Regulation Of Platelet Aggregation
Pathways		Ion channel transport Stimuli-sensing channels	Ca2+ pathway Signaling by Wnt beta-catenin independent WNT signaling
Drugs		Caffeine Dantrolene Suramin
Diseases
GWAS			Asthma ( 21907864) Obesity-related traits ( 23251661)
Protein-Protein Interactions		12 interactors: CACNA1S CALM1 CAMK2G FKBP1A HOMER1 HOMER2 HOMER3 PRKACA PRKG1 RYR2 S100A1 TRDN	34 interactors: ANXA7 CFTR CREB1 CRIP2 FAM124A FHOD1 GABRR1 GKAP1 GTF2I HDAC1 ITPR1 LASP1 LMO2 MRVI1 NPR1 PDE5A PLCB3 PPP1R12A PPP1R12B PPP1R17 PRKCA RAF1 RGS2 RYR1 SELL SEPT3 SF1 SPP1 TBXA2R TNNT1 TRIM39-RPP21 TRPC3 VASP ZNF646
Entrez ID		6261	5592
HPRD ID		01618	08910
Ensembl ID		ENSG00000196218	ENSG00000185532
Uniprot IDs		P21817	Q13976
PDB IDs			1ZXA 3NMD 3OCP 3OD0 3OGJ
Enriched GO Terms of Interacting Partners?		Regulation Of Calcium Ion Transport Regulation Of Ion Transport Regulation Of Cation Channel Activity Regulation Of Calcium Ion Transmembrane Transport Regulation Of Calcium Ion Transmembrane Transporter Activity Regulation Of Ion Transmembrane Transporter Activity Regulation Of Transmembrane Transporter Activity Regulation Of Ryanodine-sensitive Calcium-release Channel Activity Regulation Of Ion Transmembrane Transport Muscle System Process Positive Regulation Of Calcium Ion Transmembrane Transporter Activity Regulation Of Release Of Sequestered Calcium Ion Into Cytosol By Sarcoplasmic Reticulum Muscle Contraction Positive Regulation Of Calcium Ion Transport Positive Regulation Of Cation Channel Activity Positive Regulation Of Ryanodine-sensitive Calcium-release Channel Activity Second-messenger-mediated Signaling Positive Regulation Of Ion Transmembrane Transporter Activity Regulation Of Ion Homeostasis Positive Regulation Of Transporter Activity Regulation Of Release Of Sequestered Calcium Ion Into Cytosol Calcium-mediated Signaling Using Intracellular Calcium Source Positive Regulation Of Ion Transport Positive Regulation Of Ion Transmembrane Transport Regulation Of Calcium Ion Transport Into Cytosol Response To Organic Cyclic Compound Regulation Of Cardiac Muscle Contraction By Regulation Of The Release Of Sequestered Calcium Ion Regulation Of Store-operated Calcium Entry G-protein Coupled Glutamate Receptor Signaling Pathway Calcium-mediated Signaling Regulation Of Cardiac Muscle Contraction By Calcium Ion Signaling Calcium Ion Transport Release Of Sequestered Calcium Ion Into Cytosol Positive Regulation Of Transport Response To Alkaloid Regulation Of Muscle Contraction Regulation Of Sequestering Of Calcium Ion Regulation Of Heart Contraction Response To Organonitrogen Compound Calcium Ion Transport Into Cytosol Cytosolic Calcium Ion Transport Cytosolic Calcium Ion Homeostasis Chemical Homeostasis Muscle Structure Development Regulation Of Cell Communication By Electrical Coupling Involved In Cardiac Conduction Myotube Differentiation Response To Stimulus Glutamate Receptor Signaling Pathway Release Of Sequestered Calcium Ion Into Cytosol By Sarcoplasmic Reticulum Response To Organic Substance	Regulation Of Body Fluid Levels Hemostasis Regulation Of Muscle Contraction Blood Coagulation Negative Regulation Of Muscle Contraction Regulation Of Cardiac Muscle Hypertrophy Wound Healing Response To Wounding Cellular Response To Stimulus Response To Stimulus Positive Regulation Of Cardiac Muscle Hypertrophy Regulation Of Cellular Process Response To Organic Substance Cellular Cation Homeostasis Cellular Ion Homeostasis Cellular Calcium Ion Homeostasis Relaxation Of Muscle Calcium Ion Homeostasis Regulation Of Blood Vessel Size Regulation Of Tube Size Blood Circulation Signal Transduction Cellular Chemical Homeostasis Regulation Of Phospholipase Activity Platelet Activation Ion Homeostasis Neurotrophin TRK Receptor Signaling Pathway Vasodilation Neurotrophin Signaling Pathway Cellular Metal Ion Homeostasis Signaling Cell Communication Muscle System Process Cellular Homeostasis Metal Ion Homeostasis Relaxation Of Vascular Smooth Muscle Activation Of Phospholipase C Activity Positive Regulation Of Metabolic Process Regulation Of Smooth Muscle Contraction Relaxation Of Smooth Muscle Positive Regulation Of Phospholipase C Activity Regulation Of Ion Homeostasis Epidermal Growth Factor Receptor Signaling Pathway Fibroblast Growth Factor Receptor Signaling Pathway ERBB Signaling Pathway Response To Purine-containing Compound Cytosolic Calcium Ion Homeostasis Chemical Homeostasis Cellular Response To Fibroblast Growth Factor Stimulus Relaxation Of Cardiac Muscle
Tagcloud ?		19q13 adenoma arm atp1a3 bands bckdha benign boundary breakpoint chromosome communication cosmids cytogenetic distal ercc1 establishment mapped mapping p35 p36 pold1 probes q13 subset sv40 thyroid transformed translocations trpt	1n9c acsl3 agpat3 bovinesnp50 bta1 c10 c12 c14 c18 chuk dgat1 echs1 ehhadh groundwork htr1b lipj lipk minpp1 mogat1 nfkb2 osbpl8 oxct1 plink scd1 sfa sorbs1 ufa underling unraveling
Tagcloud (Difference) ?		19q13 adenoma arm atp1a3 bands bckdha benign boundary breakpoint chromosome communication cosmids cytogenetic distal ercc1 establishment mapped mapping p35 p36 pold1 probes q13 subset sv40 thyroid transformed translocations trpt	1n9c acsl3 agpat3 bovinesnp50 bta1 c10 c12 c14 c18 chuk dgat1 echs1 ehhadh groundwork htr1b lipj lipk minpp1 mogat1 nfkb2 osbpl8 oxct1 plink scd1 sfa sorbs1 ufa underling unraveling
Tagcloud (Intersection) ?