PRKG1 and PPP1R12B

Number of citations of the paper that reports this interaction (PMID 10567269)
92

Data Source:
BioGRID (two hybrid)

		PRKG1	PPP1R12B
Gene Name		protein kinase, cGMP-dependent, type I	protein phosphatase 1, regulatory subunit 12B
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Cytoplasm Golgi Apparatus Cytosol Plasma Membrane	Nucleoplasm Cytoplasm
	Molecular Function	CGMP-dependent Protein Kinase Activity Calcium Channel Regulator Activity Protein Binding ATP Binding CGMP Binding	Enzyme Activator Activity
	Biological Process	Neuron Migration Protein Phosphorylation Signal Transduction Blood Coagulation Dendrite Development CGMP-mediated Signaling Actin Cytoskeleton Organization Forebrain Development Regulation Of GTPase Activity Relaxation Of Vascular Smooth Muscle Negative Regulation Of Platelet Aggregation	G2/M Transition Of Mitotic Cell Cycle Mitotic Cell Cycle Regulation Of Muscle Contraction Signal Transduction Positive Regulation Of Catalytic Activity
Pathways		Ca2+ pathway Signaling by Wnt beta-catenin independent WNT signaling
Drugs
Diseases
GWAS		Asthma ( 21907864) Obesity-related traits ( 23251661)	Obesity-related traits ( 23251661)
Protein-Protein Interactions		34 interactors: ANXA7 CFTR CREB1 CRIP2 FAM124A FHOD1 GABRR1 GKAP1 GTF2I HDAC1 ITPR1 LASP1 LMO2 MRVI1 NPR1 PDE5A PLCB3 PPP1R12A PPP1R12B PPP1R17 PRKCA RAF1 RGS2 RYR1 SELL SEPT3 SF1 SPP1 TBXA2R TNNT1 TRIM39-RPP21 TRPC3 VASP ZNF646	3 interactors: IL16 PPP1CB PRKG1
Entrez ID		5592	4660
HPRD ID		08910	04794
Ensembl ID		ENSG00000185532	ENSG00000077157
Uniprot IDs		Q13976	E1CKY7 O60237
PDB IDs		1ZXA 3NMD 3OCP 3OD0 3OGJ
Enriched GO Terms of Interacting Partners?		Regulation Of Body Fluid Levels Hemostasis Regulation Of Muscle Contraction Blood Coagulation Negative Regulation Of Muscle Contraction Regulation Of Cardiac Muscle Hypertrophy Wound Healing Response To Wounding Cellular Response To Stimulus Response To Stimulus Positive Regulation Of Cardiac Muscle Hypertrophy Regulation Of Cellular Process Response To Organic Substance Cellular Cation Homeostasis Cellular Ion Homeostasis Cellular Calcium Ion Homeostasis Relaxation Of Muscle Calcium Ion Homeostasis Regulation Of Blood Vessel Size Regulation Of Tube Size Blood Circulation Signal Transduction Cellular Chemical Homeostasis Regulation Of Phospholipase Activity Platelet Activation Ion Homeostasis Neurotrophin TRK Receptor Signaling Pathway Vasodilation Neurotrophin Signaling Pathway Cellular Metal Ion Homeostasis Signaling Cell Communication Muscle System Process Cellular Homeostasis Metal Ion Homeostasis Relaxation Of Vascular Smooth Muscle Activation Of Phospholipase C Activity Positive Regulation Of Metabolic Process Regulation Of Smooth Muscle Contraction Relaxation Of Smooth Muscle Positive Regulation Of Phospholipase C Activity Regulation Of Ion Homeostasis Epidermal Growth Factor Receptor Signaling Pathway Fibroblast Growth Factor Receptor Signaling Pathway ERBB Signaling Pathway Response To Purine-containing Compound Cytosolic Calcium Ion Homeostasis Chemical Homeostasis Cellular Response To Fibroblast Growth Factor Stimulus Relaxation Of Cardiac Muscle	Regulation Of Glycogen Catabolic Process Relaxation Of Vascular Smooth Muscle CGMP-mediated Signaling Relaxation Of Smooth Muscle Negative Regulation Of Platelet Aggregation Negative Regulation Of Smooth Muscle Contraction Regulation Of Cell Adhesion Regulation Of Platelet Aggregation Induction Of Positive Chemotaxis Negative Regulation Of Platelet Activation Entrainment Of Circadian Clock By Photoperiod Triglyceride Catabolic Process Negative Regulation Of Muscle Contraction Relaxation Of Muscle Photoperiodism Entrainment Of Circadian Clock Acylglycerol Catabolic Process Cell Migration Regulation Of Glycogen Biosynthetic Process Positive Regulation Of Positive Chemotaxis Cyclic-nucleotide-mediated Signaling Regulation Of Platelet Activation Vasodilation Cell Motility Regulation Of Glycogen Metabolic Process Regulation Of Smooth Muscle Contraction Negative Regulation Of Blood Coagulation Negative Regulation Of Coagulation Glycogen Metabolic Process Locomotion Negative Regulation Of Wound Healing Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Regulation Of Generation Of Precursor Metabolites And Energy Regulation Of Blood Vessel Size Regulation Of Tube Size Circadian Regulation Of Gene Expression Polysaccharide Metabolic Process Movement Of Cell Or Subcellular Component Regulation Of Circadian Rhythm Triglyceride Metabolic Process Regulation Of Blood Coagulation Regulation Of Glucose Metabolic Process Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Leukocyte Chemotaxis Neutral Lipid Metabolic Process Negative Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Negative Regulation Of Cellular Response To Growth Factor Stimulus Negative Regulation Of Homotypic Cell-cell Adhesion Positive Regulation Of Chemotaxis G2/M Transition Of Mitotic Cell Cycle
Tagcloud ?		1n9c acsl3 agpat3 bovinesnp50 bta1 c10 c12 c14 c18 chuk dgat1 echs1 ehhadh groundwork htr1b lipj lipk minpp1 mogat1 nfkb2 osbpl8 oxct1 plink scd1 sfa sorbs1 ufa underling unraveling
Tagcloud (Difference) ?		1n9c acsl3 agpat3 bovinesnp50 bta1 c10 c12 c14 c18 chuk dgat1 echs1 ehhadh groundwork htr1b lipj lipk minpp1 mogat1 nfkb2 osbpl8 oxct1 plink scd1 sfa sorbs1 ufa underling unraveling
Tagcloud (Intersection) ?