RYR1 and TRDN

Number of citations of the paper that reports this interaction (PMID 9287354)
99

Data Source:
HPRD (in vivo, in vitro)

		RYR1	TRDN
Gene Name		ryanodine receptor 1 (skeletal)	triadin
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Cytoplasm Smooth Endoplasmic Reticulum Plasma Membrane Integral Component Of Plasma Membrane Cell Cortex Junctional Sarcoplasmic Reticulum Membrane Terminal Cisterna Sarcoplasmic Reticulum Junctional Membrane Complex T-tubule I Band Sarcoplasmic Reticulum Membrane Extracellular Vesicular Exosome	Cytoplasm Endoplasmic Reticulum Plasma Membrane Voltage-gated Calcium Channel Complex Junctional Sarcoplasmic Reticulum Membrane Integral Component Of Membrane Sarcoplasmic Reticulum Junctional Membrane Complex Sarcoplasmic Reticulum Membrane Sarcoplasmic Reticulum Lumen Calcium Channel Complex
	Molecular Function	Protease Binding Ryanodine-sensitive Calcium-release Channel Activity Voltage-gated Calcium Channel Activity Calcium Channel Activity Protein Binding Calmodulin Binding Calcium-release Channel Activity	Receptor Binding Protein Binding Protein Binding, Bridging Protein Homodimerization Activity Ion Channel Binding
	Biological Process	Response To Hypoxia Outflow Tract Morphogenesis Calcium Ion Transport Muscle Contraction Release Of Sequestered Calcium Ion Into Cytosol By Sarcoplasmic Reticulum Response To Caffeine Ion Transmembrane Transport Skin Development Ossification Involved In Bone Maturation Skeletal Muscle Fiber Development Release Of Sequestered Calcium Ion Into Cytosol Cytosolic Calcium Ion Homeostasis Transmembrane Transport Calcium Ion Transmembrane Transport Cellular Response To Caffeine	Cellular Calcium Ion Homeostasis Muscle Contraction Regulation Of Cell Communication By Electrical Coupling Regulation Of Release Of Sequestered Calcium Ion Into Cytosol By Sarcoplasmic Reticulum Release Of Sequestered Calcium Ion Into Cytosol By Sarcoplasmic Reticulum Cytoplasmic Microtubule Organization Ion Transmembrane Transport Regulation Of Release Of Sequestered Calcium Ion Into Cytosol Transmembrane Transport Heart Contraction Negative Regulation Of Ryanodine-sensitive Calcium-release Channel Activity Positive Regulation Of Ryanodine-sensitive Calcium-release Channel Activity Regulation Of Cardiac Muscle Cell Membrane Potential Endoplasmic Reticulum Membrane Organization Positive Regulation Of Cell Communication By Electrical Coupling Involved In Cardiac Conduction
Pathways		Ion channel transport Stimuli-sensing channels	Ion channel transport Stimuli-sensing channels
Drugs		Caffeine Dantrolene Suramin
Diseases
GWAS
Protein-Protein Interactions		12 interactors: CACNA1S CALM1 CAMK2G FKBP1A HOMER1 HOMER2 HOMER3 PRKACA PRKG1 RYR2 S100A1 TRDN	5 interactors: ASPH CALM1 CASQ2 HRC RYR1
Entrez ID		6261	10345
HPRD ID		01618	04474
Ensembl ID		ENSG00000196218	ENSG00000186439
Uniprot IDs		P21817	H9ME53 Q13061 Q68D40 Q8IVK2
PDB IDs
Enriched GO Terms of Interacting Partners?		Regulation Of Calcium Ion Transport Regulation Of Ion Transport Regulation Of Cation Channel Activity Regulation Of Calcium Ion Transmembrane Transport Regulation Of Calcium Ion Transmembrane Transporter Activity Regulation Of Ion Transmembrane Transporter Activity Regulation Of Transmembrane Transporter Activity Regulation Of Ryanodine-sensitive Calcium-release Channel Activity Regulation Of Ion Transmembrane Transport Muscle System Process Positive Regulation Of Calcium Ion Transmembrane Transporter Activity Regulation Of Release Of Sequestered Calcium Ion Into Cytosol By Sarcoplasmic Reticulum Muscle Contraction Positive Regulation Of Calcium Ion Transport Positive Regulation Of Cation Channel Activity Positive Regulation Of Ryanodine-sensitive Calcium-release Channel Activity Second-messenger-mediated Signaling Positive Regulation Of Ion Transmembrane Transporter Activity Regulation Of Ion Homeostasis Positive Regulation Of Transporter Activity Regulation Of Release Of Sequestered Calcium Ion Into Cytosol Calcium-mediated Signaling Using Intracellular Calcium Source Positive Regulation Of Ion Transport Positive Regulation Of Ion Transmembrane Transport Regulation Of Calcium Ion Transport Into Cytosol Response To Organic Cyclic Compound Regulation Of Cardiac Muscle Contraction By Regulation Of The Release Of Sequestered Calcium Ion Regulation Of Store-operated Calcium Entry G-protein Coupled Glutamate Receptor Signaling Pathway Calcium-mediated Signaling Regulation Of Cardiac Muscle Contraction By Calcium Ion Signaling Calcium Ion Transport Release Of Sequestered Calcium Ion Into Cytosol Positive Regulation Of Transport Response To Alkaloid Regulation Of Muscle Contraction Regulation Of Sequestering Of Calcium Ion Regulation Of Heart Contraction Response To Organonitrogen Compound Calcium Ion Transport Into Cytosol Cytosolic Calcium Ion Transport Cytosolic Calcium Ion Homeostasis Chemical Homeostasis Muscle Structure Development Regulation Of Cell Communication By Electrical Coupling Involved In Cardiac Conduction Myotube Differentiation Response To Stimulus Glutamate Receptor Signaling Pathway Release Of Sequestered Calcium Ion Into Cytosol By Sarcoplasmic Reticulum Response To Organic Substance	Regulation Of Cell Communication By Electrical Coupling Regulation Of Cardiac Muscle Contraction By Regulation Of The Release Of Sequestered Calcium Ion Regulation Of Cardiac Muscle Contraction By Calcium Ion Signaling Regulation Of Release Of Sequestered Calcium Ion Into Cytosol By Sarcoplasmic Reticulum Regulation Of Ryanodine-sensitive Calcium-release Channel Activity Regulation Of Ion Homeostasis Muscle Contraction Muscle System Process Regulation Of Calcium Ion Transmembrane Transport Regulation Of Calcium Ion Transmembrane Transporter Activity Regulation Of Release Of Sequestered Calcium Ion Into Cytosol Regulation Of Cation Channel Activity Regulation Of Cardiac Muscle Contraction Regulation Of Calcium Ion Transport Into Cytosol Detection Of Calcium Ion Regulation Of Striated Muscle Contraction Calcium-mediated Signaling Regulation Of Ion Transmembrane Transport Second-messenger-mediated Signaling Regulation Of Ion Transmembrane Transporter Activity Regulation Of Transmembrane Transporter Activity Regulation Of Muscle Contraction Regulation Of Heart Contraction Regulation Of Ion Transport Regulation Of Calcium Ion Transport Regulation Of Heart Rate Regulation Of Cell Communication By Electrical Coupling Involved In Cardiac Conduction Regulation Of Intracellular Transport Positive Regulation Of Ryanodine-sensitive Calcium-release Channel Activity Response To Calcium Ion Negative Regulation Of Ryanodine-sensitive Calcium-release Channel Activity Cellular Response To Caffeine Response To Purine-containing Compound Negative Regulation Of Calcium Ion Transmembrane Transporter Activity Negative Regulation Of Cation Channel Activity Response To Organonitrogen Compound Positive Regulation Of Calcium Ion Transmembrane Transporter Activity Response To Organic Cyclic Compound Response To Caffeine Regulation Of Cellular Localization Positive Regulation Of Cation Channel Activity Cellular Calcium Ion Homeostasis Calcium Ion Homeostasis Response To Metal Ion Cellular Response To Alkaloid Negative Regulation Of Transporter Activity Negative Regulation Of Calcium Ion Transport Negative Regulation Of Ion Transmembrane Transport Detection Of Chemical Stimulus Positive Regulation Of Ion Transmembrane Transporter Activity
Tagcloud ?		19q13 adenoma arm atp1a3 bands bckdha benign boundary breakpoint chromosome communication cosmids cytogenetic distal ercc1 establishment mapped mapping p35 p36 pold1 probes q13 subset sv40 thyroid transformed translocations trpt
Tagcloud (Difference) ?		19q13 adenoma arm atp1a3 bands bckdha benign boundary breakpoint chromosome communication cosmids cytogenetic distal ercc1 establishment mapped mapping p35 p36 pold1 probes q13 subset sv40 thyroid transformed translocations trpt
Tagcloud (Intersection) ?