RING1 and BMI1

Number of citations of the paper that reports this interaction (PMID 9199346)
42

Data Source:
HPRD (in vivo, in vitro)

		RING1	BMI1
Gene Name		ring finger protein 1	BMI1 proto-oncogene, polycomb ring finger
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Sex Chromatin Nucleus Nucleoplasm Cytoplasm Nuclear Speck PcG Protein Complex PRC1 Complex	Ubiquitin Ligase Complex Heterochromatin Nucleus Nucleoplasm Cytoplasm Nuclear Body PcG Protein Complex PRC1 Complex
	Molecular Function	Chromatin Binding Ubiquitin-protein Transferase Activity Protein Binding Zinc Ion Binding Ligase Activity	Chromatin Binding Ubiquitin-protein Transferase Activity Protein Binding Zinc Ion Binding Sequence-specific DNA Binding RING-like Zinc Finger Domain Binding
	Biological Process	Transcription, DNA-templated Anterior/posterior Pattern Specification Histone H2A Monoubiquitination Negative Regulation Of Transcription, DNA-templated Camera-type Eye Morphogenesis	Negative Regulation Of Transcription From RNA Polymerase II Promoter In Utero Embryonic Development DNA Methylation Transcription, DNA-templated Humoral Immune Response Segment Specification Brain Development Regulation Of Gene Expression Histone Acetylation Histone Ubiquitination Rostrocaudal Neural Tube Patterning Hemopoiesis Positive Regulation Of B Cell Proliferation Positive Regulation Of Immature T Cell Proliferation In Thymus Somatic Stem Cell Division Positive Regulation Of Fibroblast Proliferation Embryonic Skeletal System Morphogenesis Positive Regulation Of Ubiquitin-protein Transferase Activity Negative Regulation Of Apoptotic Signaling Pathway
Pathways		Oxidative Stress Induced Senescence Cellular Senescence	Oxidative Stress Induced Senescence Cellular Senescence
Drugs
Diseases
GWAS		Wegener's granulomatosis ( 23740775)
Protein-Protein Interactions		31 interactors: APP BMI1 CBX4 CBX6 CBX7 CBX8 E2F6 ELAC2 FBXO38 FHL1 HIST3H3 PCGF1 PCGF2 PCGF3 PCGF5 PCGF6 PHC1 PIK3R3 RB1 RNF2 RYBP UBE2D1 UBE2D2 UBE2D3 UBE2D4 UBE2E1 UBE2E2 UBE2E3 UBE2K USP7 YAF2	35 interactors: CBX6 CBX7 CBX8 CSNK2B E2F6 FOXS1 H2AFX HIST2H2AA3 HIST2H2AC HIST3H3 IMMT KAT5 KIAA1377 KMT2A LRIF1 MAPK14 NDEL1 PCGF3 PCGF6 PHC1 PHC2 PTN RING1 RNF114 RNF2 RRM1 SOCS2 TRIM27 TUSC3 UBE2D3 UBE2I USP11 USP7 VPS11 ZBTB16
Entrez ID		6015	648
HPRD ID		03624	01277
Ensembl ID		ENSG00000204227	ENSG00000168283
Uniprot IDs		Q06587	P35226
PDB IDs			2H0D 3RPG
Enriched GO Terms of Interacting Partners?		Protein Modification By Small Protein Conjugation Protein Ubiquitination Protein K48-linked Ubiquitination Histone Ubiquitination Chromatin Modification Chromatin Organization Negative Regulation Of Transcription From RNA Polymerase II Promoter Chromosome Organization Negative Regulation Of Transcription, DNA-templated Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of RNA Biosynthetic Process Protein Polyubiquitination Negative Regulation Of Gene Expression Transcription, DNA-templated Negative Regulation Of Biosynthetic Process RNA Biosynthetic Process RNA Metabolic Process Cellular Metabolic Process Negative Regulation Of Cellular Metabolic Process Histone Modification Regulation Of Transcription From RNA Polymerase II Promoter Gene Expression Protein Monoubiquitination Nucleobase-containing Compound Metabolic Process Cellular Protein Modification Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Regulation Of Transcription, DNA-templated Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Histone Monoubiquitination Regulation Of RNA Metabolic Process Cellular Nitrogen Compound Metabolic Process Protein K11-linked Ubiquitination Regulation Of Gene Expression Nitrogen Compound Metabolic Process Regulation Of Nitrogen Compound Metabolic Process Cellular Macromolecule Biosynthetic Process Macromolecule Biosynthetic Process Regulation Of Mitotic Cell Cycle Phase Transition Histone H2A Monoubiquitination Regulation Of Cell Cycle Phase Transition Cellular Protein Metabolic Process Regulation Of Metabolic Process Histone H2A Ubiquitination Organelle Organization Metabolic Process Biosynthetic Process Regulation Of Transcription From RNA Polymerase II Promoter In Response To Hypoxia Regulation Of Proteasomal Protein Catabolic Process	Negative Regulation Of Transcription, DNA-templated Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of RNA Biosynthetic Process Protein Ubiquitination Negative Regulation Of Transcription From RNA Polymerase II Promoter Protein Modification By Small Protein Conjugation Negative Regulation Of Gene Expression Negative Regulation Of Biosynthetic Process Transcription, DNA-templated Chromatin Organization RNA Biosynthetic Process Regulation Of Transcription From RNA Polymerase II Promoter Chromosome Organization Chromatin Modification Histone Ubiquitination Cellular Macromolecule Biosynthetic Process Cellular Protein Modification Process Negative Regulation Of Cellular Metabolic Process Nucleobase-containing Compound Metabolic Process Macromolecule Biosynthetic Process Histone Modification Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Organelle Organization Cellular Nitrogen Compound Metabolic Process RNA Metabolic Process Regulation Of Metabolic Process Regulation Of Transcription, DNA-templated Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Gene Expression Regulation Of RNA Metabolic Process Regulation Of Nitrogen Compound Metabolic Process Nitrogen Compound Metabolic Process Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Cellular Metabolic Process Protein Monoubiquitination Proteasomal Protein Catabolic Process Biosynthetic Process Cellular Protein Metabolic Process Regulation Of Gene Expression Response To Ionizing Radiation Mitotic Cell Cycle Cell Cycle Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Histone H2A Monoubiquitination Histone H2A Ubiquitination Protein Metabolic Process Negative Regulation Of Interleukin-2 Production Histone Monoubiquitination
Tagcloud ?		4h accomplish antioxidant ck cmv cortex creatine de dehydrogenase downregulated e3 electrophoresis extremely finger hselm lactate ldh ligase nontg secretase sel selenium selenoprotein selm spots synaptotagmin sytxv tg upregulated	activators coimmunoprecipitate colocalize combs drosophila eed enhancer enx1 esc example extra ezh2 homolog homology hpc2 hybrid interacts melanogaster osteosarcoma pcg polycomb progeny repressors screen trithorax trxg unlike z zeste
Tagcloud (Difference) ?		4h accomplish antioxidant ck cmv cortex creatine de dehydrogenase downregulated e3 electrophoresis extremely finger hselm lactate ldh ligase nontg secretase sel selenium selenoprotein selm spots synaptotagmin sytxv tg upregulated	activators coimmunoprecipitate colocalize combs drosophila eed enhancer enx1 esc example extra ezh2 homolog homology hpc2 hybrid interacts melanogaster osteosarcoma pcg polycomb progeny repressors screen trithorax trxg unlike z zeste
Tagcloud (Intersection) ?