BMI1 and RNF114

Number of citations of the paper that reports this interaction (PMID 22493164)
2

Data Source:
BioGRID (two hybrid)

		BMI1	RNF114
Gene Name		BMI1 proto-oncogene, polycomb ring finger	ring finger protein 114
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Ubiquitin Ligase Complex Heterochromatin Nucleus Nucleoplasm Cytoplasm Nuclear Body PcG Protein Complex PRC1 Complex	Intracellular Nucleus Cytoplasm
	Molecular Function	Chromatin Binding Ubiquitin-protein Transferase Activity Protein Binding Zinc Ion Binding Sequence-specific DNA Binding RING-like Zinc Finger Domain Binding	Zinc Ion Binding Ligase Activity
	Biological Process	Negative Regulation Of Transcription From RNA Polymerase II Promoter In Utero Embryonic Development DNA Methylation Transcription, DNA-templated Humoral Immune Response Segment Specification Brain Development Regulation Of Gene Expression Histone Acetylation Histone Ubiquitination Rostrocaudal Neural Tube Patterning Hemopoiesis Positive Regulation Of B Cell Proliferation Positive Regulation Of Immature T Cell Proliferation In Thymus Somatic Stem Cell Division Positive Regulation Of Fibroblast Proliferation Embryonic Skeletal System Morphogenesis Positive Regulation Of Ubiquitin-protein Transferase Activity Negative Regulation Of Apoptotic Signaling Pathway	Multicellular Organismal Development Spermatogenesis Protein Ubiquitination Cell Differentiation
Pathways		Oxidative Stress Induced Senescence Cellular Senescence
Drugs
Diseases
GWAS			Psoriasis ( 20953189)
Protein-Protein Interactions		35 interactors: CBX6 CBX7 CBX8 CSNK2B E2F6 FOXS1 H2AFX HIST2H2AA3 HIST2H2AC HIST3H3 IMMT KAT5 KIAA1377 KMT2A LRIF1 MAPK14 NDEL1 PCGF3 PCGF6 PHC1 PHC2 PTN RING1 RNF114 RNF2 RRM1 SOCS2 TRIM27 TUSC3 UBE2D3 UBE2I USP11 USP7 VPS11 ZBTB16	26 interactors: AK5 BMI1 EVI2A MAPK3 RNF38 RPSA TRAF4 TRAF6 TRAIP TRIM52 TRIM55 UBC UBE2D1 UBE2D2 UBE2D3 UBE2D4 UBE2DNL UBE2E1 UBE2E2 UBE2E3 UBE2H UBE2K UBE2U UBE2W UEVLD XAF1
Entrez ID		648	55905
HPRD ID		01277	10329
Ensembl ID		ENSG00000168283	ENSG00000124226
Uniprot IDs		P35226	Q9Y508
PDB IDs		2H0D 3RPG
Enriched GO Terms of Interacting Partners?		Negative Regulation Of Transcription, DNA-templated Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of RNA Biosynthetic Process Protein Ubiquitination Negative Regulation Of Transcription From RNA Polymerase II Promoter Protein Modification By Small Protein Conjugation Negative Regulation Of Gene Expression Negative Regulation Of Biosynthetic Process Transcription, DNA-templated Chromatin Organization RNA Biosynthetic Process Regulation Of Transcription From RNA Polymerase II Promoter Chromosome Organization Chromatin Modification Histone Ubiquitination Cellular Macromolecule Biosynthetic Process Cellular Protein Modification Process Negative Regulation Of Cellular Metabolic Process Nucleobase-containing Compound Metabolic Process Macromolecule Biosynthetic Process Histone Modification Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Organelle Organization Cellular Nitrogen Compound Metabolic Process RNA Metabolic Process Regulation Of Metabolic Process Regulation Of Transcription, DNA-templated Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Gene Expression Regulation Of RNA Metabolic Process Regulation Of Nitrogen Compound Metabolic Process Nitrogen Compound Metabolic Process Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Cellular Metabolic Process Protein Monoubiquitination Proteasomal Protein Catabolic Process Biosynthetic Process Cellular Protein Metabolic Process Regulation Of Gene Expression Response To Ionizing Radiation Mitotic Cell Cycle Cell Cycle Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Histone H2A Monoubiquitination Histone H2A Ubiquitination Protein Metabolic Process Negative Regulation Of Interleukin-2 Production Histone Monoubiquitination	Protein Ubiquitination Protein Polyubiquitination Protein Modification By Small Protein Conjugation Protein K48-linked Ubiquitination Protein K11-linked Ubiquitination Cellular Protein Modification Process Cellular Protein Metabolic Process TRIF-dependent Toll-like Receptor Signaling Pathway MyD88-independent Toll-like Receptor Signaling Pathway Toll-like Receptor 3 Signaling Pathway Toll-like Receptor 4 Signaling Pathway Ubiquitin-dependent Protein Catabolic Process Modification-dependent Protein Catabolic Process Toll-like Receptor Signaling Pathway Proteolysis Involved In Cellular Protein Catabolic Process Cellular Protein Catabolic Process Protein Metabolic Process Pattern Recognition Receptor Signaling Pathway Innate Immune Response-activating Signal Transduction Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Proteasomal Protein Catabolic Process Cellular Macromolecule Catabolic Process Protein Catabolic Process Activation Of Innate Immune Response Regulation Of Transcription From RNA Polymerase II Promoter In Response To Hypoxia Positive Regulation Of Innate Immune Response Protein K63-linked Ubiquitination Regulation Of Innate Immune Response Positive Regulation Of Protein Ubiquitination Regulation Of Transcription From RNA Polymerase II Promoter In Response To Stress Regulation Of DNA-templated Transcription In Response To Stress Positive Regulation Of Ubiquitin-protein Transferase Activity Positive Regulation Of Transferase Activity Positive Regulation Of Ligase Activity Cellular Response To Stress Proteolysis Regulation Of Protein Ubiquitination Regulation Of Ubiquitin-protein Transferase Activity Cellular Response To Hypoxia Cellular Response To Decreased Oxygen Levels Apoptotic Process Cellular Response To Oxygen Levels Programmed Cell Death Histone Ubiquitination Catabolic Process Immune Response-regulating Signaling Pathway Cell Death Death Protein Monoubiquitination Innate Immune Response
Tagcloud ?		activators coimmunoprecipitate colocalize combs drosophila eed enhancer enx1 esc example extra ezh2 homolog homology hpc2 hybrid interacts melanogaster osteosarcoma pcg polycomb progeny repressors screen trithorax trxg unlike z zeste
Tagcloud (Difference) ?		activators coimmunoprecipitate colocalize combs drosophila eed enhancer enx1 esc example extra ezh2 homolog homology hpc2 hybrid interacts melanogaster osteosarcoma pcg polycomb progeny repressors screen trithorax trxg unlike z zeste
Tagcloud (Intersection) ?