RING1 and CBX6

Number of citations of the paper that reports this interaction (PMID 21282530)
11

Data Source:
BioGRID (pull down)

		RING1	CBX6
Gene Name		ring finger protein 1	chromobox homolog 6
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Sex Chromatin Nucleus Nucleoplasm Cytoplasm Nuclear Speck PcG Protein Complex PRC1 Complex	Heterochromatin Nucleus Nucleoplasm PcG Protein Complex
	Molecular Function	Chromatin Binding Ubiquitin-protein Transferase Activity Protein Binding Zinc Ion Binding Ligase Activity	Single-stranded RNA Binding Protein Binding
	Biological Process	Transcription, DNA-templated Anterior/posterior Pattern Specification Histone H2A Monoubiquitination Negative Regulation Of Transcription, DNA-templated Camera-type Eye Morphogenesis	Negative Regulation Of Transcription From RNA Polymerase II Promoter Transcription, DNA-templated Chromatin Modification
Pathways		Oxidative Stress Induced Senescence Cellular Senescence	Oxidative Stress Induced Senescence Cellular Senescence
Drugs
Diseases
GWAS		Wegener's granulomatosis ( 23740775)	Bladder cancer ( 20972438)
Protein-Protein Interactions		31 interactors: APP BMI1 CBX4 CBX6 CBX7 CBX8 E2F6 ELAC2 FBXO38 FHL1 HIST3H3 PCGF1 PCGF2 PCGF3 PCGF5 PCGF6 PHC1 PIK3R3 RB1 RNF2 RYBP UBE2D1 UBE2D2 UBE2D3 UBE2D4 UBE2E1 UBE2E2 UBE2E3 UBE2K USP7 YAF2	9 interactors: BMI1 HOXC9 PCGF1 PCGF2 PCGF3 PCGF5 PCGF6 RING1 RNF2
Entrez ID		6015	23466
HPRD ID		03624	13005
Ensembl ID		ENSG00000204227	ENSG00000183741
Uniprot IDs		Q06587	B0QXZ6 O95503
PDB IDs			3GV6 3I90
Enriched GO Terms of Interacting Partners?		Protein Modification By Small Protein Conjugation Protein Ubiquitination Protein K48-linked Ubiquitination Histone Ubiquitination Chromatin Modification Chromatin Organization Negative Regulation Of Transcription From RNA Polymerase II Promoter Chromosome Organization Negative Regulation Of Transcription, DNA-templated Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of RNA Biosynthetic Process Protein Polyubiquitination Negative Regulation Of Gene Expression Transcription, DNA-templated Negative Regulation Of Biosynthetic Process RNA Biosynthetic Process RNA Metabolic Process Cellular Metabolic Process Negative Regulation Of Cellular Metabolic Process Histone Modification Regulation Of Transcription From RNA Polymerase II Promoter Gene Expression Protein Monoubiquitination Nucleobase-containing Compound Metabolic Process Cellular Protein Modification Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Regulation Of Transcription, DNA-templated Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Histone Monoubiquitination Regulation Of RNA Metabolic Process Cellular Nitrogen Compound Metabolic Process Protein K11-linked Ubiquitination Regulation Of Gene Expression Nitrogen Compound Metabolic Process Regulation Of Nitrogen Compound Metabolic Process Cellular Macromolecule Biosynthetic Process Macromolecule Biosynthetic Process Regulation Of Mitotic Cell Cycle Phase Transition Histone H2A Monoubiquitination Regulation Of Cell Cycle Phase Transition Cellular Protein Metabolic Process Regulation Of Metabolic Process Histone H2A Ubiquitination Organelle Organization Metabolic Process Biosynthetic Process Regulation Of Transcription From RNA Polymerase II Promoter In Response To Hypoxia Regulation Of Proteasomal Protein Catabolic Process	Histone Ubiquitination Transcription, DNA-templated RNA Biosynthetic Process Histone H2A Monoubiquitination Histone H2A Ubiquitination Anterior/posterior Pattern Specification RNA Metabolic Process Gene Expression Histone Monoubiquitination Cellular Macromolecule Biosynthetic Process Macromolecule Biosynthetic Process Histone Modification Regulation Of Transcription, DNA-templated Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of RNA Metabolic Process Pattern Specification Process Protein Monoubiquitination Nucleobase-containing Compound Metabolic Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Biosynthetic Process Regulation Of Gene Expression Regulation Of Nitrogen Compound Metabolic Process Cellular Nitrogen Compound Metabolic Process Protein Ubiquitination Chromatin Modification Protein Modification By Small Protein Conjugation Nitrogen Compound Metabolic Process Chromatin Organization Embryonic Skeletal System Morphogenesis Chromosome Organization Negative Regulation Of Transcription, DNA-templated Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of RNA Biosynthetic Process Embryonic Skeletal System Development Regulation Of Metabolic Process Negative Regulation Of Gene Expression Negative Regulation Of Biosynthetic Process Embryonic Morphogenesis Skeletal System Morphogenesis Negative Regulation Of Transcription From RNA Polymerase II Promoter Embryonic Organ Morphogenesis Organ Morphogenesis Negative Regulation Of Cellular Metabolic Process Cellular Metabolic Process Embryo Development Embryonic Organ Development Histone H2A-K119 Monoubiquitination Histone Acetylation
Tagcloud ?		4h accomplish antioxidant ck cmv cortex creatine de dehydrogenase downregulated e3 electrophoresis extremely finger hselm lactate ldh ligase nontg secretase sel selenium selenoprotein selm spots synaptotagmin sytxv tg upregulated	acetylase aldh1a3 belonging bipotent ccnb1 ccne1 committed differentiated disrupt dysregulation encode establishment gata3 hat1 hdac1 identity luminal maintenance myoepithelial notch4 pcgf2 polycomb progenitors silico smarca4 smarcd3 smarce1 subpopulations trithorax
Tagcloud (Difference) ?		4h accomplish antioxidant ck cmv cortex creatine de dehydrogenase downregulated e3 electrophoresis extremely finger hselm lactate ldh ligase nontg secretase sel selenium selenoprotein selm spots synaptotagmin sytxv tg upregulated	acetylase aldh1a3 belonging bipotent ccnb1 ccne1 committed differentiated disrupt dysregulation encode establishment gata3 hat1 hdac1 identity luminal maintenance myoepithelial notch4 pcgf2 polycomb progenitors silico smarca4 smarcd3 smarce1 subpopulations trithorax
Tagcloud (Intersection) ?