BMI1 and TUSC3

Number of citations of the paper that reports this interaction (PMID 19451220)
14

Data Source:
BioGRID (pull down)

		BMI1	TUSC3
Gene Name		BMI1 proto-oncogene, polycomb ring finger	tumor suppressor candidate 3
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Ubiquitin Ligase Complex Heterochromatin Nucleus Nucleoplasm Cytoplasm Nuclear Body PcG Protein Complex PRC1 Complex	Mitochondrion Endoplasmic Reticulum Membrane Integral Component Of Plasma Membrane Oligosaccharyltransferase Complex
	Molecular Function	Chromatin Binding Ubiquitin-protein Transferase Activity Protein Binding Zinc Ion Binding Sequence-specific DNA Binding RING-like Zinc Finger Domain Binding	Dolichyl-diphosphooligosaccharide-protein Glycotransferase Activity Magnesium Ion Transmembrane Transporter Activity
	Biological Process	Negative Regulation Of Transcription From RNA Polymerase II Promoter In Utero Embryonic Development DNA Methylation Transcription, DNA-templated Humoral Immune Response Segment Specification Brain Development Regulation Of Gene Expression Histone Acetylation Histone Ubiquitination Rostrocaudal Neural Tube Patterning Hemopoiesis Positive Regulation Of B Cell Proliferation Positive Regulation Of Immature T Cell Proliferation In Thymus Somatic Stem Cell Division Positive Regulation Of Fibroblast Proliferation Embryonic Skeletal System Morphogenesis Positive Regulation Of Ubiquitin-protein Transferase Activity Negative Regulation Of Apoptotic Signaling Pathway	Protein N-linked Glycosylation Magnesium Ion Transport Protein N-linked Glycosylation Via Asparagine Post-translational Protein Modification Cellular Protein Metabolic Process Cell Redox Homeostasis Cognition
Pathways		Oxidative Stress Induced Senescence Cellular Senescence	Defective ALG2 causes ALG2-CDG (CDG-1i) Diseases of glycosylation Defective ALG3 causes ALG3-CDG (CDG-1d) Post-translational protein modification Defective DPAGT1 causes DPAGT1-CDG (CDG-1j) and CMSTA2 Defective ALG14 causes congenital myasthenic syndrome (ALG14-CMS) Defective MGAT2 causes MGAT2-CDG (CDG-2a) Defective ALG1 causes ALG1-CDG (CDG-1k) Defective B4GALT1 causes B4GALT1-CDG (CDG-2d) Defective RFT1 causes RFT1-CDG (CDG-1n) Defective ALG6 causes ALG6-CDG (CDG-1c) Defective MOGS causes MOGS-CDG (CDG-2b) Asparagine N-linked glycosylation Defective ALG8 causes ALG8-CDG (CDG-1h) Defective ALG9 causes ALG9-CDG (CDG-1l) Defective MAN1B1 causes MRT15 Defective MPDU1 causes MPDU1-CDG (CDG-1f) Defective ALG12 causes ALG12-CDG (CDG-1g) Diseases associated with N-glycosylation of proteins Defective ALG11 causes ALG11-CDG (CDG-1p)
Drugs
Diseases
GWAS			Intelligence ( 22449649) Methamphetamine dependence ( 23594818) Pulmonary function decline ( 22424883)
Protein-Protein Interactions		35 interactors: CBX6 CBX7 CBX8 CSNK2B E2F6 FOXS1 H2AFX HIST2H2AA3 HIST2H2AC HIST3H3 IMMT KAT5 KIAA1377 KMT2A LRIF1 MAPK14 NDEL1 PCGF3 PCGF6 PHC1 PHC2 PTN RING1 RNF114 RNF2 RRM1 SOCS2 TRIM27 TUSC3 UBE2D3 UBE2I USP11 USP7 VPS11 ZBTB16	2 interactors: BMI1 PPP1CA
Entrez ID		648	7991
HPRD ID		01277	03228
Ensembl ID		ENSG00000168283	ENSG00000104723
Uniprot IDs		P35226	D6RIY7 Q13454
PDB IDs		2H0D 3RPG
Enriched GO Terms of Interacting Partners?		Negative Regulation Of Transcription, DNA-templated Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of RNA Biosynthetic Process Protein Ubiquitination Negative Regulation Of Transcription From RNA Polymerase II Promoter Protein Modification By Small Protein Conjugation Negative Regulation Of Gene Expression Negative Regulation Of Biosynthetic Process Transcription, DNA-templated Chromatin Organization RNA Biosynthetic Process Regulation Of Transcription From RNA Polymerase II Promoter Chromosome Organization Chromatin Modification Histone Ubiquitination Cellular Macromolecule Biosynthetic Process Cellular Protein Modification Process Negative Regulation Of Cellular Metabolic Process Nucleobase-containing Compound Metabolic Process Macromolecule Biosynthetic Process Histone Modification Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Organelle Organization Cellular Nitrogen Compound Metabolic Process RNA Metabolic Process Regulation Of Metabolic Process Regulation Of Transcription, DNA-templated Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Gene Expression Regulation Of RNA Metabolic Process Regulation Of Nitrogen Compound Metabolic Process Nitrogen Compound Metabolic Process Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Cellular Metabolic Process Protein Monoubiquitination Proteasomal Protein Catabolic Process Biosynthetic Process Cellular Protein Metabolic Process Regulation Of Gene Expression Response To Ionizing Radiation Mitotic Cell Cycle Cell Cycle Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Histone H2A Monoubiquitination Histone H2A Ubiquitination Protein Metabolic Process Negative Regulation Of Interleukin-2 Production Histone Monoubiquitination	Positive Regulation Of Immature T Cell Proliferation In Thymus Positive Regulation Of Immature T Cell Proliferation Cell Division Regulation Of Glycogen Catabolic Process Tube Development Positive Regulation Of T Cell Differentiation In Thymus Segment Specification Rostrocaudal Neural Tube Patterning Triglyceride Catabolic Process Entrainment Of Circadian Clock By Photoperiod Photoperiodism Entrainment Of Circadian Clock Acylglycerol Catabolic Process Epithelium Development Negative Regulation Of Signal Transduction Somatic Stem Cell Division Negative Regulation Of Signaling Regulation Of T Cell Differentiation In Thymus Regulation Of Glycogen Biosynthetic Process Histone Ubiquitination Positive Regulation Of Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand Regulation Of Glycogen Metabolic Process Positive Regulation Of B Cell Proliferation Stem Cell Division Regulation Of Apoptotic Process Regulation Of Cell Death Regulation Of B Cell Proliferation DNA Methylation Neural Tube Patterning Glycogen Metabolic Process Tissue Development Positive Regulation Of Fibroblast Proliferation Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Positive Regulation Of Ubiquitin-protein Transferase Activity Positive Regulation Of B Cell Activation Regulation Of Generation Of Precursor Metabolites And Energy Positive Regulation Of Ligase Activity Circadian Regulation Of Gene Expression Polysaccharide Metabolic Process Positive Regulation Of T Cell Proliferation Positive Regulation Of T Cell Differentiation Regulation Of Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand Positive Regulation Of Extrinsic Apoptotic Signaling Pathway DNA Modification Regulation Of Ubiquitin-protein Transferase Activity Positive Regulation Of Lymphocyte Differentiation Triglyceride Metabolic Process Regulation Of Circadian Rhythm Regulation Of Fibroblast Proliferation Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway
Tagcloud ?		activators coimmunoprecipitate colocalize combs drosophila eed enhancer enx1 esc example extra ezh2 homolog homology hpc2 hybrid interacts melanogaster osteosarcoma pcg polycomb progeny repressors screen trithorax trxg unlike z zeste	accommodate anchored away catalyzed cysteine disulfide eukaryotes folding glycoproteins glycosylation groove hetero hydrophobic lumen mixed n33 nonsyndromic oligomer oligosaccharyl opposite orientations ost possesses prefers retardation slowing substrates thioredoxin transferase
Tagcloud (Difference) ?		activators coimmunoprecipitate colocalize combs drosophila eed enhancer enx1 esc example extra ezh2 homolog homology hpc2 hybrid interacts melanogaster osteosarcoma pcg polycomb progeny repressors screen trithorax trxg unlike z zeste	accommodate anchored away catalyzed cysteine disulfide eukaryotes folding glycoproteins glycosylation groove hetero hydrophobic lumen mixed n33 nonsyndromic oligomer oligosaccharyl opposite orientations ost possesses prefers retardation slowing substrates thioredoxin transferase
Tagcloud (Intersection) ?