RBL2 and PHB

Number of citations of the paper that reports this interaction (PMID 10376528)
44

Data Source:
HPRD (in vivo, in vitro)

		RBL2	PHB
Gene Name		retinoblastoma-like 2	prohibitin
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleus Nucleoplasm Transcription Factor Complex Nucleolus Cytoplasm Extracellular Vesicular Exosome	Nucleus Nucleoplasm Cytoplasm Mitochondrion Mitochondrial Inner Membrane Integral Component Of Plasma Membrane Membrane Extracellular Vesicular Exosome
	Molecular Function	DNA Binding Protein Binding	Sequence-specific DNA Binding RNA Polymerase II Transcription Factor Activity Protein Binding Enzyme Binding Histone Deacetylase Binding Transcription Regulatory Region DNA Binding
	Biological Process	Mitotic Cell Cycle Transcription, DNA-templated Regulation Of Transcription From RNA Polymerase II Promoter Chromatin Modification Regulation Of Lipid Kinase Activity Regulation Of Cell Cycle	Negative Regulation Of Transcription From RNA Polymerase II Promoter Osteoblast Differentiation Regulation Of Transcription, DNA-templated Transcription From RNA Polymerase II Promoter Signal Transduction Negative Regulation Of Cell Proliferation Negative Regulation Of Transcription By Competitive Promoter Binding Histone Deacetylation Negative Regulation Of Cell Growth Regulation Of Apoptotic Process Negative Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription, DNA-templated Progesterone Receptor Signaling Pathway Negative Regulation Of Androgen Receptor Signaling Pathway Cellular Response To Interleukin-6 DNA Biosynthetic Process Negative Regulation Of Glucocorticoid Receptor Signaling Pathway
Pathways		Cyclin D associated events in G1 G1 Phase G0 and Early G1 Mitotic G1-G1/S phases Cell Cycle, Mitotic
Drugs
Diseases
GWAS			Diastolic blood pressure ( 19430483) Prostate cancer ( 23535732)
Protein-Protein Interactions		42 interactors: BRCA1 BRF1 BRF2 CCNA1 CCNA2 CCND1 CCND3 CCNE1 CDK2 CDK4 CDK6 CREG1 DCTN1 DGKZ E2F4 E2F5 EZH2 GRAMD4 HBP1 HDAC1 ID2 LBX1 LDHC MCM7 MNDA PCBD1 PHB PPP2CA RAF1 RBBP8 RBBP9 RINT1 SKP2 SMARCA4 SNW1 SUV39H1 SUV420H2 TAF1 TOP1 UBTF USP4 XBP1	19 interactors: ANXA2 COX6C E2F1 ESR1 HDAC1 LONRF3 MAP3K10 NAP1L1 NCOR1 RAF1 RB1 RBL1 RBL2 SIN3A SMARCA2 SMARCA4 SUMO4 TP53 XPO1
Entrez ID		5934	5245
HPRD ID		01576	01454
Ensembl ID		ENSG00000103479	ENSG00000167085
Uniprot IDs		Q08999 Q8NE70	A8K401 B4DY47 P35232 Q53FV0
PDB IDs			1LU7
Enriched GO Terms of Interacting Partners?		Cell Cycle Mitotic Cell Cycle Phase Transition Cell Cycle Phase Transition G1/S Transition Of Mitotic Cell Cycle Mitotic Cell Cycle Regulation Of Cell Cycle Regulation Of Gene Expression Cell Cycle Process Regulation Of Metabolic Process Mitotic Cell Cycle Process Regulation Of Nitrogen Compound Metabolic Process Nucleobase-containing Compound Metabolic Process Positive Regulation Of Cellular Metabolic Process Regulation Of Transcription, DNA-templated Cellular Macromolecule Biosynthetic Process Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Macromolecule Biosynthetic Process Regulation Of RNA Metabolic Process Positive Regulation Of Metabolic Process Cellular Nitrogen Compound Metabolic Process Transcription, DNA-templated RNA Biosynthetic Process Cell Division Regulation Of Cell Proliferation Regulation Of Mitotic Cell Cycle Phase Transition Regulation Of Cell Cycle Phase Transition Negative Regulation Of Cell Cycle RNA Metabolic Process Positive Regulation Of Gene Expression Nitrogen Compound Metabolic Process Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of Cellular Biosynthetic Process Regulation Of Cell Cycle Process Biosynthetic Process Gene Expression Positive Regulation Of Macromolecule Biosynthetic Process Regulation Of Mitotic Cell Cycle Chromatin Organization Positive Regulation Of Transcription, DNA-templated Regulation Of Cellular Process DNA-templated Transcription, Initiation Cellular Metabolic Process Organelle Organization Regulation Of Cellular Protein Metabolic Process Chromosome Organization Cellular Response To Stress Regulation Of Protein Kinase Activity	Chromatin Organization Negative Regulation Of Gene Expression Chromosome Organization Negative Regulation Of Transcription From RNA Polymerase II Promoter Negative Regulation Of Transcription, DNA-templated Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of RNA Biosynthetic Process Chromatin Modification Negative Regulation Of Biosynthetic Process Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of Cellular Metabolic Process Negative Regulation Of Cellular Metabolic Process Regulation Of Cell Cycle Positive Regulation Of Transcription From RNA Polymerase II Promoter Organelle Organization Transforming Growth Factor Beta Receptor Signaling Pathway Positive Regulation Of Cellular Biosynthetic Process Positive Regulation Of Metabolic Process Transcription From RNA Polymerase II Promoter Chromatin Remodeling Transcription, DNA-templated Cellular Response To Transforming Growth Factor Beta Stimulus Positive Regulation Of Transcription, DNA-templated Response To Transforming Growth Factor Beta RNA Biosynthetic Process Regulation Of Fibroblast Proliferation Regulation Of Cellular Component Organization Regulation Of Mitotic Cell Cycle Phase Transition Negative Regulation Of Transcription From RNA Polymerase II Promoter During Mitosis Aortic Smooth Muscle Cell Differentiation Regulation Of Cell Proliferation Regulation Of Cell Cycle Phase Transition Positive Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Signal Transduction Positive Regulation Of Gene Expression Mitotic Cell Cycle Regulation Of Nitrogen Compound Metabolic Process Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Regulation Of Cell Cycle Process Gene Expression Negative Regulation Of Signaling Negative Regulation Of Transcription Involved In G1/S Transition Of Mitotic Cell Cycle Regulation Of Transcription, DNA-templated Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Cellular Macromolecule Biosynthetic Process Regulation Of RNA Metabolic Process Macromolecule Biosynthetic Process Regulation Of Phosphorylation Rhythmic Process
Tagcloud ?		arginine bcl3 casp10 dap1 derepression epigenetic epigenetically governs hdac1 hodgkin hoxa5 hrk indirectly lymphoma master methyltransferase offer p52 polycomb prc2 prmt5 rb1 reactivation repression repressor retinoblastoma tp53k372 trigger turn	bacterium briefly cloned comamonas deduced degrading depolymerase depolymerases distinguished encodes exfoliatus gram homologies homology hydrolysis hydrolyze hydroxyalkanoate hydroxybutyrate hydroxyoctanoate isolate k10 pha phaz pho poly sp streptomyces subgroup utilize
Tagcloud (Difference) ?		arginine bcl3 casp10 dap1 derepression epigenetic epigenetically governs hdac1 hodgkin hoxa5 hrk indirectly lymphoma master methyltransferase offer p52 polycomb prc2 prmt5 rb1 reactivation repression repressor retinoblastoma tp53k372 trigger turn	bacterium briefly cloned comamonas deduced degrading depolymerase depolymerases distinguished encodes exfoliatus gram homologies homology hydrolysis hydrolyze hydroxyalkanoate hydroxybutyrate hydroxyoctanoate isolate k10 pha phaz pho poly sp streptomyces subgroup utilize
Tagcloud (Intersection) ?