PHB and SIN3A

Number of citations of the paper that reports this interaction (PMID 12466959)
57

Data Source:
HPRD (in vivo)

		PHB	SIN3A
Gene Name		prohibitin	SIN3 transcription regulator family member A
Image
Gene Ontology Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Mitochondrion Mitochondrial Inner Membrane Integral Component Of Plasma Membrane Membrane Extracellular Vesicular Exosome	Kinetochore Nucleus Nucleoplasm Transcription Factor Complex Nucleolus Cytoplasm Sin3 Complex Transcriptional Repressor Complex Intercellular Bridge
	Molecular Function	Sequence-specific DNA Binding RNA Polymerase II Transcription Factor Activity Protein Binding Enzyme Binding Histone Deacetylase Binding Transcription Regulatory Region DNA Binding	Transcription Regulatory Region Sequence-specific DNA Binding RNA Polymerase II Activating Transcription Factor Binding RNA Polymerase II Repressing Transcription Factor Binding RNA Polymerase II Transcription Corepressor Activity Chromatin Binding Sequence-specific DNA Binding Transcription Factor Activity Histone Deacetylase Activity Protein Binding Protein Complex Binding Protein Deacetylase Activity
	Biological Process	Negative Regulation Of Transcription From RNA Polymerase II Promoter Osteoblast Differentiation Regulation Of Transcription, DNA-templated Transcription From RNA Polymerase II Promoter Signal Transduction Negative Regulation Of Cell Proliferation Negative Regulation Of Transcription By Competitive Promoter Binding Histone Deacetylation Negative Regulation Of Cell Growth Regulation Of Apoptotic Process Negative Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription, DNA-templated Progesterone Receptor Signaling Pathway Negative Regulation Of Androgen Receptor Signaling Pathway Cellular Response To Interleukin-6 DNA Biosynthetic Process Negative Regulation Of Glucocorticoid Receptor Signaling Pathway	Negative Regulation Of Transcription From RNA Polymerase II Promoter In Utero Embryonic Development Activation Of Innate Immune Response Positive Regulation Of Defense Response To Virus By Host Hematopoietic Progenitor Cell Differentiation DNA Replication Transcription, DNA-templated Protein Deacetylation Aging Blood Coagulation Response To Organonitrogen Compound Gene Expression Positive Regulation Of G2/M Transition Of Mitotic Cell Cycle Histone Deacetylation Positive Regulation Of Chromatin Silencing Cellular Protein Localization Regulation Of Gene Expression, Epigenetic Negative Regulation Of Circadian Rhythm Negative Regulation Of Apoptotic Process Regulation Of Transcription From RNA Polymerase II Promoter In Response To Oxidative Stress Cellular Lipid Metabolic Process Small Molecule Metabolic Process Negative Regulation Of Gene Expression, Epigenetic Negative Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription From RNA Polymerase II Promoter Rhythmic Process Response To Methylglyoxal Cellular Response To Glucose Stimulus Negative Regulation Of Protein Localization To Nucleus Negative Regulation Of Histone H3-K27 Acetylation Negative Regulation Of Transcription Regulatory Region DNA Binding
Pathways			NoRC negatively regulates rRNA expression Fatty acid, triacylglycerol, and ketone body metabolism Metabolism of lipids and lipoproteins Epigenetic regulation of gene expression Negative epigenetic regulation of rRNA expression Regulation of lipid metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha) Factors involved in megakaryocyte development and platelet production
Drugs
Diseases
GWAS		Diastolic blood pressure ( 19430483) Prostate cancer ( 23535732)	Height ( 20189936) Sudden cardiac arrest ( 21658281)
Protein-Protein Interactions		19 interactors: ANXA2 COX6C E2F1 ESR1 HDAC1 LONRF3 MAP3K10 NAP1L1 NCOR1 RAF1 RB1 RBL1 RBL2 SIN3A SMARCA2 SMARCA4 SUMO4 TP53 XPO1	90 interactors: ARID4A ARID4B BCL6 BCL6B BHLHE40 BRMS1 BRMS1L CBFA2T2 COPS2 CTBP1 CTCF CUL4B DACH1 DDB1 DDX20 DHX30 ETV6 HBP1 HCFC1 HDAC1 HDAC2 HDAC7 HDAC9 HEY2 HIST3H3 HTT IKZF1 IKZF4 ING1 IRF5 KLF10 KLF11 KLF13 KLF16 KLF9 LINC00152 LRCH4 MAD1L1 MBD2 MBD4 MECP2 MEN1 MNT MORF4L2 MXD1 MXD3 MXD4 MXI1 MYB NCOR2 NFKB1 NFKB2 NR2E3 OGT PA2G4 PHB PHF12 PML PRMT5 PTMA RBBP4 RBBP7 RBP1 RBPJ REL RELA RELB RLIM RUNX1T1 SAP18 SAP30 SETDB1 SFPQ SKI SMAD3 SMARCA4 SMARCC1 SMARCE1 SNW1 SPI1 STAT3 SYT1 TAL1 TFCP2 TGIF1 THAP11 TOPORS TP53 TRIM28 ZBTB16
Entrez ID		5245	25942
HPRD ID		01454	09690
Ensembl ID		ENSG00000167085	ENSG00000169375
Uniprot IDs		A8K401 B4DY47 P35232 Q53FV0	Q96ST3
PDB IDs		1LU7	1PO4
Enriched GO Terms of Interacting Partners?		Chromatin Organization Negative Regulation Of Gene Expression Chromosome Organization Negative Regulation Of Transcription From RNA Polymerase II Promoter Negative Regulation Of Transcription, DNA-templated Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of RNA Biosynthetic Process Chromatin Modification Negative Regulation Of Biosynthetic Process Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of Cellular Metabolic Process Negative Regulation Of Cellular Metabolic Process Regulation Of Cell Cycle Positive Regulation Of Transcription From RNA Polymerase II Promoter Organelle Organization Transforming Growth Factor Beta Receptor Signaling Pathway Positive Regulation Of Cellular Biosynthetic Process Positive Regulation Of Metabolic Process Transcription From RNA Polymerase II Promoter Chromatin Remodeling Transcription, DNA-templated Cellular Response To Transforming Growth Factor Beta Stimulus Positive Regulation Of Transcription, DNA-templated Response To Transforming Growth Factor Beta RNA Biosynthetic Process Regulation Of Fibroblast Proliferation Regulation Of Cellular Component Organization Regulation Of Mitotic Cell Cycle Phase Transition Negative Regulation Of Transcription From RNA Polymerase II Promoter During Mitosis Aortic Smooth Muscle Cell Differentiation Regulation Of Cell Proliferation Regulation Of Cell Cycle Phase Transition Positive Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Signal Transduction Positive Regulation Of Gene Expression Mitotic Cell Cycle Regulation Of Nitrogen Compound Metabolic Process Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Regulation Of Cell Cycle Process Gene Expression Negative Regulation Of Signaling Negative Regulation Of Transcription Involved In G1/S Transition Of Mitotic Cell Cycle Regulation Of Transcription, DNA-templated Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Cellular Macromolecule Biosynthetic Process Regulation Of RNA Metabolic Process Macromolecule Biosynthetic Process Regulation Of Phosphorylation Rhythmic Process	Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of RNA Biosynthetic Process Negative Regulation Of Transcription, DNA-templated Negative Regulation Of Gene Expression Negative Regulation Of Biosynthetic Process Regulation Of Transcription From RNA Polymerase II Promoter Negative Regulation Of Transcription From RNA Polymerase II Promoter Transcription, DNA-templated RNA Biosynthetic Process RNA Metabolic Process Negative Regulation Of Cellular Metabolic Process Gene Expression Regulation Of Transcription, DNA-templated Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Cellular Macromolecule Biosynthetic Process Regulation Of RNA Metabolic Process Nucleobase-containing Compound Metabolic Process Heterocycle Metabolic Process Macromolecule Biosynthetic Process Cellular Aromatic Compound Metabolic Process Cellular Nitrogen Compound Metabolic Process Regulation Of Gene Expression Regulation Of Nitrogen Compound Metabolic Process Nitrogen Compound Metabolic Process Biosynthetic Process Regulation Of Metabolic Process Transcription From RNA Polymerase II Promoter Chromatin Organization Chromatin Modification Chromosome Organization Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Gene Expression Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Cellular Biosynthetic Process Positive Regulation Of Transcription From RNA Polymerase II Promoter Cellular Metabolic Process Regulation Of Cellular Process Histone Modification Positive Regulation Of Cellular Metabolic Process Negative Regulation Of Cell Proliferation Regulation Of Gene Expression, Epigenetic Positive Regulation Of Metabolic Process Regulation Of Cell Proliferation Negative Regulation Of Gene Expression, Epigenetic Organelle Organization Regulation Of Cell Differentiation Regulation Of Chromosome Organization Regulation Of Histone Modification Cell Differentiation
Tagcloud ?		bacterium briefly cloned comamonas deduced degrading depolymerase depolymerases distinguished encodes exfoliatus gram homologies homology hydrolysis hydrolyze hydroxyalkanoate hydroxybutyrate hydroxyoctanoate isolate k10 pha phaz pho poly sp streptomyces subgroup utilize	ablated bcl6 conducive cor corepressors deacteylases erbaalpha erbbeta interactiondomains laz3 locks mad mxi physicalassociation rev rid rids rip13a rip13delta1 rpd3 rvr sin3b tafii32 tafii70 tafs terminalrepression tfiib zip
Tagcloud (Difference) ?		bacterium briefly cloned comamonas deduced degrading depolymerase depolymerases distinguished encodes exfoliatus gram homologies homology hydrolysis hydrolyze hydroxyalkanoate hydroxybutyrate hydroxyoctanoate isolate k10 pha phaz pho poly sp streptomyces subgroup utilize	ablated bcl6 conducive cor corepressors deacteylases erbaalpha erbbeta interactiondomains laz3 locks mad mxi physicalassociation rev rid rids rip13a rip13delta1 rpd3 rvr sin3b tafii32 tafii70 tafs terminalrepression tfiib zip
Tagcloud (Intersection) ?