PHB and SUMO4

Number of citations of the paper that reports this interaction (PMID 16236267)
15

Data Source:
HPRD (in vivo)

		PHB	SUMO4
Gene Name		prohibitin	small ubiquitin-like modifier 4
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Mitochondrion Mitochondrial Inner Membrane Integral Component Of Plasma Membrane Membrane Extracellular Vesicular Exosome	Nucleus
	Molecular Function	Sequence-specific DNA Binding RNA Polymerase II Transcription Factor Activity Protein Binding Enzyme Binding Histone Deacetylase Binding Transcription Regulatory Region DNA Binding
	Biological Process	Negative Regulation Of Transcription From RNA Polymerase II Promoter Osteoblast Differentiation Regulation Of Transcription, DNA-templated Transcription From RNA Polymerase II Promoter Signal Transduction Negative Regulation Of Cell Proliferation Negative Regulation Of Transcription By Competitive Promoter Binding Histone Deacetylation Negative Regulation Of Cell Growth Regulation Of Apoptotic Process Negative Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription, DNA-templated Progesterone Receptor Signaling Pathway Negative Regulation Of Androgen Receptor Signaling Pathway Cellular Response To Interleukin-6 DNA Biosynthetic Process Negative Regulation Of Glucocorticoid Receptor Signaling Pathway	Protein Sumoylation
Pathways
Drugs
Diseases
GWAS		Diastolic blood pressure ( 19430483) Prostate cancer ( 23535732)
Protein-Protein Interactions		19 interactors: ANXA2 COX6C E2F1 ESR1 HDAC1 LONRF3 MAP3K10 NAP1L1 NCOR1 RAF1 RB1 RBL1 RBL2 SIN3A SMARCA2 SMARCA4 SUMO4 TP53 XPO1	75 interactors: ACADM ACO2 ACTG1 ALDOA ARHGDIA ATP5B CALR CAT CCT2 CCT5 CCT6A CCT7 CLIC1 DNAJA1 DNAJB11 EIF3I ENO1 ENO2 FOS G6PD GAPDH GMPS GNB2L1 GSTP1 HNRNPD HNRNPF HNRNPH1 HNRNPL HSPA1B HSPA5 HSPA8 HSPA9 HSPD1 IDH1 IDH3A IMPDH2 JUN LDHB LMNA LMNB1 MRPS22 NFKBIA NR3C1 PA2G4 PAFAH1B3 PDIA3 PDIA6 PGK1 PHB PHGDH PITHD1 PPA1 PRDX2 PRDX3 PRDX4 PRDX6 PRPS1 PSMC2 RPSA SF3B4 SPINT2 STAT1 STAT3 STIP1 STOML2 STRAP TFAP2A TOP2A TPM3 TUBA1C TXNL1 UBE2V1 VCP VDAC1 ZPR1
Entrez ID		5245	387082
HPRD ID		01454	10584
Ensembl ID		ENSG00000167085	ENSG00000177688
Uniprot IDs		A8K401 B4DY47 P35232 Q53FV0	Q6EEV6
PDB IDs		1LU7
Enriched GO Terms of Interacting Partners?		Chromatin Organization Negative Regulation Of Gene Expression Chromosome Organization Negative Regulation Of Transcription From RNA Polymerase II Promoter Negative Regulation Of Transcription, DNA-templated Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of RNA Biosynthetic Process Chromatin Modification Negative Regulation Of Biosynthetic Process Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of Cellular Metabolic Process Negative Regulation Of Cellular Metabolic Process Regulation Of Cell Cycle Positive Regulation Of Transcription From RNA Polymerase II Promoter Organelle Organization Transforming Growth Factor Beta Receptor Signaling Pathway Positive Regulation Of Cellular Biosynthetic Process Positive Regulation Of Metabolic Process Transcription From RNA Polymerase II Promoter Chromatin Remodeling Transcription, DNA-templated Cellular Response To Transforming Growth Factor Beta Stimulus Positive Regulation Of Transcription, DNA-templated Response To Transforming Growth Factor Beta RNA Biosynthetic Process Regulation Of Fibroblast Proliferation Regulation Of Cellular Component Organization Regulation Of Mitotic Cell Cycle Phase Transition Negative Regulation Of Transcription From RNA Polymerase II Promoter During Mitosis Aortic Smooth Muscle Cell Differentiation Regulation Of Cell Proliferation Regulation Of Cell Cycle Phase Transition Positive Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Signal Transduction Positive Regulation Of Gene Expression Mitotic Cell Cycle Regulation Of Nitrogen Compound Metabolic Process Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Regulation Of Cell Cycle Process Gene Expression Negative Regulation Of Signaling Negative Regulation Of Transcription Involved In G1/S Transition Of Mitotic Cell Cycle Regulation Of Transcription, DNA-templated Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Cellular Macromolecule Biosynthetic Process Regulation Of RNA Metabolic Process Macromolecule Biosynthetic Process Regulation Of Phosphorylation Rhythmic Process	Protein Folding Regulation Of Cell Death Regulation Of Apoptotic Process Cellular Metabolic Process Response To Unfolded Protein Response To Stress Negative Regulation Of Cell Death 'de Novo' Protein Folding Cellular Nitrogen Compound Metabolic Process Negative Regulation Of Apoptotic Process Negative Regulation Of Programmed Cell Death Toxin Transport Response To Organic Substance Nitrogen Compound Metabolic Process 'de Novo' Posttranslational Protein Folding Metabolic Process Cellular Response To Stress Heterocycle Metabolic Process Nucleobase-containing Compound Metabolic Process Response To Endoplasmic Reticulum Stress Generation Of Precursor Metabolites And Energy Regulation Of Cellular Protein Metabolic Process Response To Oxidative Stress Positive Regulation Of Cellular Metabolic Process Cellular Aromatic Compound Metabolic Process Cellular Process Response To Reactive Oxygen Species Small Molecule Metabolic Process Organic Acid Metabolic Process Hydrogen Peroxide Catabolic Process Regulation Of Protein Metabolic Process Carboxylic Acid Metabolic Process Protein Refolding Endoplasmic Reticulum Unfolded Protein Response Ribonucleoside Monophosphate Biosynthetic Process Carbohydrate Biosynthetic Process Cellular Response To Organic Substance MRNA Metabolic Process Cellular Response To Unfolded Protein Activation Of Signaling Protein Activity Involved In Unfolded Protein Response Positive Regulation Of Nuclease Activity Nucleoside Monophosphate Biosynthetic Process Gluconeogenesis Monocarboxylic Acid Metabolic Process ER-nucleus Signaling Pathway Catabolic Process Ribose Phosphate Biosynthetic Process Apoptotic Process Biosynthetic Process Cellular Response To Topologically Incorrect Protein
Tagcloud ?		bacterium briefly cloned comamonas deduced degrading depolymerase depolymerases distinguished encodes exfoliatus gram homologies homology hydrolysis hydrolyze hydroxyalkanoate hydroxybutyrate hydroxyoctanoate isolate k10 pha phaz pho poly sp streptomyces subgroup utilize	accumulating behcet ccr1 ccr3 ccr6 cd40 ctla4 elucidating fcrl3 han helpful hopefully il17 il23r immunoregulatory irf5 l2 mcp multisystemic mystery opn predisposition profound ptpn22 regimes stat4 tgfbr3 tgrbr3 ubac2
Tagcloud (Difference) ?		bacterium briefly cloned comamonas deduced degrading depolymerase depolymerases distinguished encodes exfoliatus gram homologies homology hydrolysis hydrolyze hydroxyalkanoate hydroxybutyrate hydroxyoctanoate isolate k10 pha phaz pho poly sp streptomyces subgroup utilize	accumulating behcet ccr1 ccr3 ccr6 cd40 ctla4 elucidating fcrl3 han helpful hopefully il17 il23r immunoregulatory irf5 l2 mcp multisystemic mystery opn predisposition profound ptpn22 regimes stat4 tgfbr3 tgrbr3 ubac2
Tagcloud (Intersection) ?