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RNF11 and CBLB
Number of citations of the paper that reports this interaction (PMID
15231748
)
65
Data Source:
HPRD
(two hybrid)
RNF11
CBLB
Gene Name
ring finger protein 11
Cbl proto-oncogene B, E3 ubiquitin protein ligase
Image
No pdb structure
Gene Ontology Annotations
Cellular Component
Ubiquitin Ligase Complex
Nucleus
Early Endosome
Recycling Endosome
Extracellular Vesicular Exosome
Nucleoplasm
Cytoplasm
Cytosol
Plasma Membrane
Molecular Function
DNA Binding
Ubiquitin-protein Transferase Activity
Protein Binding
Zinc Ion Binding
Phosphotyrosine Binding
Ubiquitin-protein Transferase Activity
Signal Transducer Activity
Calcium Ion Binding
Protein Binding
Zinc Ion Binding
Ligase Activity
Biological Process
Protein Ubiquitination Involved In Ubiquitin-dependent Protein Catabolic Process
Protein Autoubiquitination
Positive Regulation Of T Cell Anergy
NLS-bearing Protein Import Into Nucleus
Immune Response
Signal Transduction
Cell Surface Receptor Signaling Pathway
Protein Ubiquitination
Intracellular Signal Transduction
T Cell Activation
Positive Regulation Of Protein Catabolic Process
Negative Regulation Of Alpha-beta T Cell Proliferation
Negative Regulation Of T Cell Receptor Signaling Pathway
Pathways
Signaling by the B Cell Receptor (BCR)
Antigen processing: Ubiquitination & Proteasome degradation
Class I MHC mediated antigen processing & presentation
Antigen activates B Cell Receptor (BCR) leading to generation of second messengers
Adaptive Immune System
Drugs
Diseases
GWAS
Ventricular conduction (
21076409
)
Multiple sclerosis (
20453840
)
Protein-Protein Interactions
68 interactors:
AKT1
ANKRD13A
APP
ASCC2
AUP1
CALCOCO2
CBLB
CCDC127
DCUN1D1
EPN1
EPN2
EPN3
EPS15
ERCC6
GGA1
GGA2
GGA3
HERC1
HERC2
HUWE1
IKBKG
ITCH
MYO6
NEDD4
NEDD4L
OPTN
PDCD6IP
POLI
PTPRC
QARS
RABGEF1
RIPK1
RNF168
RNF216
RPS27A
SDCBP
SMURF1
SMURF2
SNRNP70
SPRTN
STAM2
STAMBP
STAMBPL1
TAX1BP1
TNFAIP3
TNIP1
TOM1L2
UBA52
UBAC1
UBB
UBC
UBE2D1
UBE2D2
UBE2D3
UBE2D4
UBE2E1
UBE2E2
UBE2E3
UBE2N
UBE2U
UBQLN2
UBQLN4
USP5
WWP1
WWP2
ZFYVE16
ZFYVE9
ZNF350
32 interactors:
ARHGEF7
BLNK
CRKL
CRY1
EGFR
FLT3
FYB
FYN
GLRX3
GORASP2
GRB2
HNRNPK
KIT
NCK1
NCK2
NEDD4
PIK3R1
PLCG2
RET
RNF11
SH3KBP1
SHC1
SORBS3
SPRY2
SYK
TGFB1I1
TNFRSF11A
UBASH3B
UBC
VAV1
VAV2
ZAP70
Entrez ID
26994
868
HPRD ID
09955
05136
Ensembl ID
ENSG00000123091
ENSG00000114423
Uniprot IDs
Q9Y3C5
B3KSS7
Q13191
PDB IDs
2AK5
2BZ8
2DO6
2J6F
2JNH
2LDR
2OOA
2OOB
3PFV
3VGO
3ZNI
Enriched GO Terms of Interacting Partners
?
Protein Ubiquitination
Protein Polyubiquitination
Protein Modification By Small Protein Conjugation
Protein Catabolic Process
Cellular Protein Catabolic Process
Proteolysis Involved In Cellular Protein Catabolic Process
Ubiquitin-dependent Protein Catabolic Process
Modification-dependent Protein Catabolic Process
Protein K48-linked Ubiquitination
Cellular Macromolecule Catabolic Process
Positive Regulation Of Protein Catabolic Process
Pattern Recognition Receptor Signaling Pathway
Innate Immune Response-activating Signal Transduction
Activation Of Innate Immune Response
Proteolysis
Nucleotide-binding Domain, Leucine Rich Repeat Containing Receptor Signaling Pathway
Negative Regulation Of Signal Transduction
Positive Regulation Of Innate Immune Response
Regulation Of Protein Catabolic Process
Nucleotide-binding Oligomerization Domain Containing Signaling Pathway
Cellular Protein Modification Process
Regulation Of Type I Interferon Production
Toll-like Receptor Signaling Pathway
Negative Regulation Of Signaling
Toll-like Receptor 4 Signaling Pathway
Protein K63-linked Ubiquitination
Protein Ubiquitination Involved In Ubiquitin-dependent Protein Catabolic Process
Regulation Of Innate Immune Response
TRIF-dependent Toll-like Receptor Signaling Pathway
Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process
Catabolic Process
Cellular Protein Metabolic Process
Proteasomal Protein Catabolic Process
MyD88-independent Toll-like Receptor Signaling Pathway
Toll-like Receptor 3 Signaling Pathway
Positive Regulation Of Protein Metabolic Process
Negative Regulation Of Type I Interferon Production
Regulation Of Transcription From RNA Polymerase II Promoter In Response To Hypoxia
Immune Response-regulating Signaling Pathway
Regulation Of Transcription From RNA Polymerase II Promoter In Response To Stress
Intracellular Transport
Cellular Response To Stress
Regulation Of DNA-templated Transcription In Response To Stress
Transforming Growth Factor Beta Receptor Signaling Pathway
Protein Metabolic Process
Intracellular Protein Transport
Negative Regulation Of Cellular Response To Growth Factor Stimulus
Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway
Innate Immune Response
Cellular Response To Stimulus
Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway
Enzyme Linked Receptor Protein Signaling Pathway
Epidermal Growth Factor Receptor Signaling Pathway
ERBB Signaling Pathway
Positive Regulation Of Signal Transduction
Regulation Of Signal Transduction
Immune Response-regulating Cell Surface Receptor Signaling Pathway
Cell Activation
Regulation Of Signaling
Cell Surface Receptor Signaling Pathway
Immune System Process
Immune Response-regulating Signaling Pathway
Fc Receptor Signaling Pathway
Neurotrophin TRK Receptor Signaling Pathway
Neurotrophin Signaling Pathway
Fc-epsilon Receptor Signaling Pathway
Cell Migration
Locomotion
Immune Response-activating Cell Surface Receptor Signaling Pathway
Regulation Of Epidermal Growth Factor Receptor Signaling Pathway
Lymphocyte Activation
Immune Response
Signal Transduction
Cell Motility
Regulation Of ERBB Signaling Pathway
Cellular Response To Growth Factor Stimulus
Leukocyte Migration
Response To Growth Factor
Regulation Of Kinase Activity
Positive Regulation Of Intracellular Signal Transduction
Regulation Of Intracellular Signal Transduction
Leukocyte Activation
Signaling
Fibroblast Growth Factor Receptor Signaling Pathway
Cell Communication
Regulation Of Phosphorylation
Regulation Of Immune System Process
Single Organismal Cell-cell Adhesion
Regulation Of Immune Response
Cellular Response To Fibroblast Growth Factor Stimulus
Response To Fibroblast Growth Factor
Cell Adhesion
Regulation Of Phosphorus Metabolic Process
Antigen Receptor-mediated Signaling Pathway
Movement Of Cell Or Subcellular Component
Innate Immune Response
Response To Organic Substance
Intracellular Signal Transduction
Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis
Fc-gamma Receptor Signaling Pathway
Tagcloud
?
calm3
ccna2
ccnd3
cdk6
cited1
dems
dok
elk3
fyn
git1
hck
lck
module
modules
nonmodule
p85beta
pdgfra
pib5pa
psd93
ptch2
sam68
sh3kbp1
shc
tgfbr1
tgfbr2
vav2
wilcoxon
yes
zfyve9
Tagcloud (Difference)
?
calm3
ccna2
ccnd3
cdk6
cited1
dems
dok
elk3
fyn
git1
hck
lck
module
modules
nonmodule
p85beta
pdgfra
pib5pa
psd93
ptch2
sam68
sh3kbp1
shc
tgfbr1
tgfbr2
vav2
wilcoxon
yes
zfyve9
Tagcloud (Intersection)
?