PPP3CA and ATP2B4

Number of citations of the paper that reports this interaction (PMID 15955804)
16

Data Source:
HPRD (in vivo)

		PPP3CA	ATP2B4
Gene Name		protein phosphatase 3, catalytic subunit, alpha isozyme	ATPase, Ca++ transporting, plasma membrane 4
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Gene Ontology Annotations	Cellular Component	Nucleoplasm Cytoplasm Mitochondrion Cytosol Calcineurin Complex Z Disc Sarcolemma	Plasma Membrane Integral Component Of Plasma Membrane Caveola Membrane Z Disc T-tubule Protein Complex
	Molecular Function	Protein Serine/threonine Phosphatase Activity Calcium Ion Binding Protein Binding Calmodulin Binding Drug Binding Enzyme Binding Calmodulin-dependent Protein Phosphatase Activity Protein Heterodimerization Activity Protein Dimerization Activity	Calcium-transporting ATPase Activity Protein Binding Calmodulin Binding ATP Binding Sodium Channel Regulator Activity Protein Phosphatase 2B Binding Nitric-oxide Synthase Inhibitor Activity Metal Ion Binding Nitric-oxide Synthase Binding Scaffold Protein Binding
	Biological Process	G1/S Transition Of Mitotic Cell Cycle Response To Amphetamine Protein Dephosphorylation Protein Import Into Nucleus Calcium Ion Transport Transition Between Fast And Slow Fiber Dephosphorylation Calcineurin-NFAT Signaling Cascade Multicellular Organismal Response To Stress Cellular Response To Drug Fc-epsilon Receptor Signaling Pathway T Cell Activation Innate Immune Response Positive Regulation Of Transcription From RNA Polymerase II Promoter Negative Regulation Of Insulin Secretion Skeletal Muscle Fiber Development Regulation Of Synaptic Transmission Positive Regulation Of NFAT Protein Import Into Nucleus Response To Calcium Ion Regulation Of Excitatory Postsynaptic Membrane Potential Cellular Response To Glucose Stimulus Positive Regulation Of Cardiac Muscle Hypertrophy In Response To Stress	Regulation Of Transcription From RNA Polymerase II Promoter Cellular Calcium Ion Homeostasis Blood Coagulation Metabolic Process Negative Regulation Of Nitric Oxide Mediated Signal Transduction Positive Regulation Of Peptidyl-serine Phosphorylation Ion Transmembrane Transport Negative Regulation Of Nitric Oxide Biosynthetic Process Negative Regulation Of Nitric-oxide Synthase Activity Response To Hydrostatic Pressure Calcium Ion Homeostasis Transmembrane Transport Calcium Ion Transmembrane Transport Negative Regulation Of Calcineurin-NFAT Signaling Cascade Cellular Response To Epinephrine Stimulus Calcium Ion Import Across Plasma Membrane Negative Regulation Of The Force Of Heart Contraction Negative Regulation Of Arginine Catabolic Process Negative Regulation Of Adrenergic Receptor Signaling Pathway Involved In Heart Process Negative Regulation Of Peptidyl-cysteine S-nitrosylation Regulation Of Sodium Ion Transmembrane Transport Negative Regulation Of Cardiac Muscle Hypertrophy In Response To Stress Negative Regulation Of Citrulline Biosynthetic Process Positive Regulation Of CAMP-dependent Protein Kinase Activity
Pathways		Signaling by GPCR Ca2+ pathway Opioid Signalling DARPP-32 events Fc epsilon receptor (FCERI) signaling FCERI mediated Ca+2 mobilization Signaling by Wnt Innate Immune System beta-catenin independent WNT signaling	Ion transport by P-type ATPases Ion channel transport Platelet homeostasis Reduction of cytosolic Ca++ levels Platelet calcium homeostasis
Drugs
Diseases
GWAS		Blood pressure ( 22763476) Corneal structure ( 21979947)	Breast size ( 22747683) Malaria ( 22895189) Mean corpuscular hemoglobin concentration ( 23263863)
Protein-Protein Interactions		24 interactors: AKAP5 ATP2B4 BAD BCL2 C16orf74 CABIN1 CASP3 CRTC2 FKBP1A FKBP8 GABRA1 GABRB2 GABRG2 GRB2 KCNIP3 MARCH7 MYOZ2 MYOZ3 PPP3R1 PRKCZ RCAN1 RCAN2 SOD1 SYNJ1	11 interactors: CASK CD22 DLG1 DLG2 DLG3 DLG4 ERBB2IP NOS1 PPP3CA RASSF1 SRC
Entrez ID		5530	493
HPRD ID		00234	00159
Ensembl ID		ENSG00000138814	ENSG00000058668
Uniprot IDs		Q08209	P23634
PDB IDs		1AUI 1M63 1MF8 2JOG 2JZI 2P6B 2R28 2W73 3LL8 4F0Z	1CFF 2KNE
Enriched GO Terms of Interacting Partners?		Response To Organonitrogen Compound Cellular Response To Organonitrogen Compound Signaling Cell Communication Behavior Cellular Response To Histamine Synaptic Transmission, GABAergic Response To Organic Cyclic Compound Calcineurin-NFAT Signaling Cascade Response To Histamine Single-organism Behavior Regulation Of Neuron Death Cellular Response To Stimulus Cellular Response To Organic Substance Regulation Of Phosphorus Metabolic Process Response To Organic Substance Signal Transduction Inositol Phosphate-mediated Signaling Cellular Response To Ammonium Ion Positive Regulation Of Signal Transduction Regulation Of Lymphocyte Activation Positive Regulation Of Protein Insertion Into Mitochondrial Membrane Involved In Apoptotic Signaling Pathway Cellular Response To Organic Cyclic Compound Response To Oxidative Stress Regulation Of Neuron Apoptotic Process Positive Regulation Of Mitochondrial Outer Membrane Permeabilization Involved In Apoptotic Signaling Pathway Regulation Of Apoptotic Process Release Of Cytochrome C From Mitochondria Gamma-aminobutyric Acid Signaling Pathway Regulation Of Cell Activation Regulation Of Mitochondrial Membrane Potential Regulation Of Mitochondrial Outer Membrane Permeabilization Involved In Apoptotic Signaling Pathway Regulation Of Cell Death Cell Surface Receptor Signaling Pathway Neurological System Process Positive Regulation Of Cellular Metabolic Process Regulation Of T Cell Activation Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors Response To Stimulus Synaptic Transmission Negative Regulation Of Apoptotic Process Cell-cell Signaling Regulation Of Immune System Process Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand Regulation Of Phosphorylation Negative Regulation Of Programmed Cell Death Regulation Of Cell Adhesion Transport Regulation Of Cell-cell Adhesion Negative Regulation Of Cell Death	Receptor Localization To Synapse Nucleotide Phosphorylation Protein Localization To Synapse Establishment Or Maintenance Of Apical/basal Cell Polarity Receptor Clustering Establishment Or Maintenance Of Epithelial Cell Apical/basal Polarity Establishment Or Maintenance Of Cell Polarity Nucleotide Metabolic Process Synaptic Transmission Cell Adhesion Nucleobase-containing Small Molecule Metabolic Process Positive Regulation Of Transport Cellular Protein Localization Protein Localization To Membrane Axon Guidance Membrane Organization Negative Regulation Of Hydrolase Activity Regulation Of Ion Transmembrane Transport Cell-cell Signaling Organophosphate Metabolic Process Cortical Actin Cytoskeleton Organization Axonogenesis Phosphorylation Phosphate-containing Compound Metabolic Process Cortical Cytoskeleton Organization Signaling Protein Localization Positive Regulation Of Ion Transport Axon Development Cell Communication Negative Regulation Of Cell Adhesion Cell Morphogenesis Involved In Neuron Differentiation Chemotaxis Regulation Of Sodium Ion Transmembrane Transport Regulation Of Ion Transport Negative Regulation Of Cell-matrix Adhesion Locomotion Neuron Projection Morphogenesis Cell Cycle Regulation Of Membrane Potential Cell Morphogenesis Involved In Differentiation Positive Regulation Of Metabolic Process Negative Regulation Of Cell-substrate Adhesion Small Molecule Metabolic Process Anatomical Structure Development Regulation Of Catalytic Activity Myotube Differentiation Regulation Of Phosphorus Metabolic Process Cellular Localization Regulation Of Synaptic Transmission
Tagcloud ?		adenocarcinoma chip coding cre dt ductal fresh g12d intraepithelial kras lincrna1611 lncrnas lsl neoplasia operation pan pancreatic panin pca pdac pdx profilings r172h resected rnas sh tissues tp53 weak
Tagcloud (Difference) ?		adenocarcinoma chip coding cre dt ductal fresh g12d intraepithelial kras lincrna1611 lncrnas lsl neoplasia operation pan pancreatic panin pca pdac pdx profilings r172h resected rnas sh tissues tp53 weak
Tagcloud (Intersection) ?