PPP3CA and GABRG2

Number of citations of the paper that reports this interaction (PMID 12574411)
27

Data Source:
HPRD (in vitro)

		PPP3CA	GABRG2
Gene Name		protein phosphatase 3, catalytic subunit, alpha isozyme	gamma-aminobutyric acid (GABA) A receptor, gamma 2
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleoplasm Cytoplasm Mitochondrion Cytosol Calcineurin Complex Z Disc Sarcolemma	Cytoplasm Plasma Membrane Integral Component Of Plasma Membrane Cell Junction Axon Dendrite Membrane Chloride Channel Complex Postsynaptic Membrane Inhibitory Synapse GABA-A Receptor Complex
	Molecular Function	Protein Serine/threonine Phosphatase Activity Calcium Ion Binding Protein Binding Calmodulin Binding Drug Binding Enzyme Binding Calmodulin-dependent Protein Phosphatase Activity Protein Heterodimerization Activity Protein Dimerization Activity	GABA-A Receptor Activity Extracellular Ligand-gated Ion Channel Activity Chloride Channel Activity Protein Binding Benzodiazepine Receptor Activity
	Biological Process	G1/S Transition Of Mitotic Cell Cycle Response To Amphetamine Protein Dephosphorylation Protein Import Into Nucleus Calcium Ion Transport Transition Between Fast And Slow Fiber Dephosphorylation Calcineurin-NFAT Signaling Cascade Multicellular Organismal Response To Stress Cellular Response To Drug Fc-epsilon Receptor Signaling Pathway T Cell Activation Innate Immune Response Positive Regulation Of Transcription From RNA Polymerase II Promoter Negative Regulation Of Insulin Secretion Skeletal Muscle Fiber Development Regulation Of Synaptic Transmission Positive Regulation Of NFAT Protein Import Into Nucleus Response To Calcium Ion Regulation Of Excitatory Postsynaptic Membrane Potential Cellular Response To Glucose Stimulus Positive Regulation Of Cardiac Muscle Hypertrophy In Response To Stress	Transport Gamma-aminobutyric Acid Signaling Pathway Synaptic Transmission Post-embryonic Development Adult Behavior Ion Transmembrane Transport Synaptic Transmission, GABAergic Transmembrane Transport Cellular Response To Histamine Chloride Transmembrane Transport
Pathways		Signaling by GPCR Ca2+ pathway Opioid Signalling DARPP-32 events Fc epsilon receptor (FCERI) signaling FCERI mediated Ca+2 mobilization Signaling by Wnt Innate Immune System beta-catenin independent WNT signaling	GABA receptor activation Ion channel transport GABA A receptor activation Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic Cell Ligand-gated ion channel transport Orphan transporters Transmission across Chemical Synapses
Drugs
Diseases
GWAS		Blood pressure ( 22763476) Corneal structure ( 21979947)
Protein-Protein Interactions		24 interactors: AKAP5 ATP2B4 BAD BCL2 C16orf74 CABIN1 CASP3 CRTC2 FKBP1A FKBP8 GABRA1 GABRB2 GABRG2 GRB2 KCNIP3 MARCH7 MYOZ2 MYOZ3 PPP3R1 PRKCZ RCAN1 RCAN2 SOD1 SYNJ1	6 interactors: DRD5 GABARAP PPP3CA PRKCA PRKCB ZDHHC3
Entrez ID		5530	2566
HPRD ID		00234	00663
Ensembl ID		ENSG00000138814	ENSG00000113327
Uniprot IDs		Q08209	P18507
PDB IDs		1AUI 1M63 1MF8 2JOG 2JZI 2P6B 2R28 2W73 3LL8 4F0Z
Enriched GO Terms of Interacting Partners?		Response To Organonitrogen Compound Cellular Response To Organonitrogen Compound Signaling Cell Communication Behavior Cellular Response To Histamine Synaptic Transmission, GABAergic Response To Organic Cyclic Compound Calcineurin-NFAT Signaling Cascade Response To Histamine Single-organism Behavior Regulation Of Neuron Death Cellular Response To Stimulus Cellular Response To Organic Substance Regulation Of Phosphorus Metabolic Process Response To Organic Substance Signal Transduction Inositol Phosphate-mediated Signaling Cellular Response To Ammonium Ion Positive Regulation Of Signal Transduction Regulation Of Lymphocyte Activation Positive Regulation Of Protein Insertion Into Mitochondrial Membrane Involved In Apoptotic Signaling Pathway Cellular Response To Organic Cyclic Compound Response To Oxidative Stress Regulation Of Neuron Apoptotic Process Positive Regulation Of Mitochondrial Outer Membrane Permeabilization Involved In Apoptotic Signaling Pathway Regulation Of Apoptotic Process Release Of Cytochrome C From Mitochondria Gamma-aminobutyric Acid Signaling Pathway Regulation Of Cell Activation Regulation Of Mitochondrial Membrane Potential Regulation Of Mitochondrial Outer Membrane Permeabilization Involved In Apoptotic Signaling Pathway Regulation Of Cell Death Cell Surface Receptor Signaling Pathway Neurological System Process Positive Regulation Of Cellular Metabolic Process Regulation Of T Cell Activation Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors Response To Stimulus Synaptic Transmission Negative Regulation Of Apoptotic Process Cell-cell Signaling Regulation Of Immune System Process Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand Regulation Of Phosphorylation Negative Regulation Of Programmed Cell Death Regulation Of Cell Adhesion Transport Regulation Of Cell-cell Adhesion Negative Regulation Of Cell Death	Histone H3-T6 Phosphorylation Synaptic Transmission Cell-cell Signaling Cellular Response To Carbohydrate Stimulus Cellular Chemical Homeostasis Positive Regulation Of Cardiac Muscle Hypertrophy Negative Regulation Of Glucose Transport Response To Carbohydrate Cellular Homeostasis Regulation Of Cardiac Muscle Hypertrophy Activation Of Adenylate Cyclase Activity Chemical Homeostasis Response To Amphetamine Mitotic Nuclear Envelope Disassembly Positive Regulation Of Adenylate Cyclase Activity Cellular Calcium Ion Homeostasis Negative Regulation Of Insulin Receptor Signaling Pathway Calcium Ion Homeostasis Histone Phosphorylation Nuclear Envelope Disassembly Positive Regulation Of Lyase Activity Peptidyl-threonine Phosphorylation Response To Amine Regulation Of Adenylate Cyclase Activity Negative Regulation Of Signaling Negative Regulation Of Transport Cellular Metal Ion Homeostasis Positive Regulation Of CAMP Biosynthetic Process Protein Targeting Regulation Of Insulin Receptor Signaling Pathway Regulation Of Cyclase Activity Nuclear Envelope Organization Positive Regulation Of CAMP Metabolic Process Cellular Cation Homeostasis Cellular Ion Homeostasis Metal Ion Homeostasis Homeostatic Process Protein Transport Regulation Of Cellular Response To Insulin Stimulus Positive Regulation Of Cyclic Nucleotide Metabolic Process Establishment Of Protein Localization Regulation Of CAMP Biosynthetic Process Cell Surface Receptor Signaling Pathway Ion Homeostasis Regulation Of Glucose Transport Transition Between Fast And Slow Fiber Positive Regulation Of Dense Core Granule Biogenesis Vascular Endothelial Growth Factor Receptor Signaling Pathway Regulation Of CAMP Metabolic Process Wound Healing
Tagcloud ?		adenocarcinoma chip coding cre dt ductal fresh g12d intraepithelial kras lincrna1611 lncrnas lsl neoplasia operation pan pancreatic panin pca pdac pdx profilings r172h resected rnas sh tissues tp53 weak	agonistic alpha6 aminobutyric antiepileptic beta3 compromise dravet dysfunctions epilepsy gabaa gabra1 gabra6 gabrb3 gabrd gamma2 gastaut gated gating hyperpolarization infantile insufficiencies lennox myoclonic nonsense pathomechanisms pentamers seizures spasms
Tagcloud (Difference) ?		adenocarcinoma chip coding cre dt ductal fresh g12d intraepithelial kras lincrna1611 lncrnas lsl neoplasia operation pan pancreatic panin pca pdac pdx profilings r172h resected rnas sh tissues tp53 weak	agonistic alpha6 aminobutyric antiepileptic beta3 compromise dravet dysfunctions epilepsy gabaa gabra1 gabra6 gabrb3 gabrd gamma2 gastaut gated gating hyperpolarization infantile insufficiencies lennox myoclonic nonsense pathomechanisms pentamers seizures spasms
Tagcloud (Intersection) ?