PPP3CA and C16orf74

Number of citations of the paper that reports this interaction (PMID 16189514)
699

Data Source:
BioGRID (two hybrid, two hybrid)
HPRD (two hybrid)

		PPP3CA	C16orf74
Gene Name		protein phosphatase 3, catalytic subunit, alpha isozyme	chromosome 16 open reading frame 74
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleoplasm Cytoplasm Mitochondrion Cytosol Calcineurin Complex Z Disc Sarcolemma
	Molecular Function	Protein Serine/threonine Phosphatase Activity Calcium Ion Binding Protein Binding Calmodulin Binding Drug Binding Enzyme Binding Calmodulin-dependent Protein Phosphatase Activity Protein Heterodimerization Activity Protein Dimerization Activity
	Biological Process	G1/S Transition Of Mitotic Cell Cycle Response To Amphetamine Protein Dephosphorylation Protein Import Into Nucleus Calcium Ion Transport Transition Between Fast And Slow Fiber Dephosphorylation Calcineurin-NFAT Signaling Cascade Multicellular Organismal Response To Stress Cellular Response To Drug Fc-epsilon Receptor Signaling Pathway T Cell Activation Innate Immune Response Positive Regulation Of Transcription From RNA Polymerase II Promoter Negative Regulation Of Insulin Secretion Skeletal Muscle Fiber Development Regulation Of Synaptic Transmission Positive Regulation Of NFAT Protein Import Into Nucleus Response To Calcium Ion Regulation Of Excitatory Postsynaptic Membrane Potential Cellular Response To Glucose Stimulus Positive Regulation Of Cardiac Muscle Hypertrophy In Response To Stress
Pathways		Signaling by GPCR Ca2+ pathway Opioid Signalling DARPP-32 events Fc epsilon receptor (FCERI) signaling FCERI mediated Ca+2 mobilization Signaling by Wnt Innate Immune System beta-catenin independent WNT signaling
Drugs
Diseases
GWAS		Blood pressure ( 22763476) Corneal structure ( 21979947)
Protein-Protein Interactions		24 interactors: AKAP5 ATP2B4 BAD BCL2 C16orf74 CABIN1 CASP3 CRTC2 FKBP1A FKBP8 GABRA1 GABRB2 GABRG2 GRB2 KCNIP3 MARCH7 MYOZ2 MYOZ3 PPP3R1 PRKCZ RCAN1 RCAN2 SOD1 SYNJ1	2 interactors: PPP3CA UNC119
Entrez ID		5530	404550
HPRD ID		00234	14460
Ensembl ID		ENSG00000138814	ENSG00000154102
Uniprot IDs		Q08209	Q96GX8
PDB IDs		1AUI 1M63 1MF8 2JOG 2JZI 2P6B 2R28 2W73 3LL8 4F0Z
Enriched GO Terms of Interacting Partners?		Response To Organonitrogen Compound Cellular Response To Organonitrogen Compound Signaling Cell Communication Behavior Cellular Response To Histamine Synaptic Transmission, GABAergic Response To Organic Cyclic Compound Calcineurin-NFAT Signaling Cascade Response To Histamine Single-organism Behavior Regulation Of Neuron Death Cellular Response To Stimulus Cellular Response To Organic Substance Regulation Of Phosphorus Metabolic Process Response To Organic Substance Signal Transduction Inositol Phosphate-mediated Signaling Cellular Response To Ammonium Ion Positive Regulation Of Signal Transduction Regulation Of Lymphocyte Activation Positive Regulation Of Protein Insertion Into Mitochondrial Membrane Involved In Apoptotic Signaling Pathway Cellular Response To Organic Cyclic Compound Response To Oxidative Stress Regulation Of Neuron Apoptotic Process Positive Regulation Of Mitochondrial Outer Membrane Permeabilization Involved In Apoptotic Signaling Pathway Regulation Of Apoptotic Process Release Of Cytochrome C From Mitochondria Gamma-aminobutyric Acid Signaling Pathway Regulation Of Cell Activation Regulation Of Mitochondrial Membrane Potential Regulation Of Mitochondrial Outer Membrane Permeabilization Involved In Apoptotic Signaling Pathway Regulation Of Cell Death Cell Surface Receptor Signaling Pathway Neurological System Process Positive Regulation Of Cellular Metabolic Process Regulation Of T Cell Activation Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors Response To Stimulus Synaptic Transmission Negative Regulation Of Apoptotic Process Cell-cell Signaling Regulation Of Immune System Process Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand Regulation Of Phosphorylation Negative Regulation Of Programmed Cell Death Regulation Of Cell Adhesion Transport Regulation Of Cell-cell Adhesion Negative Regulation Of Cell Death	Negative Regulation Of Clathrin-mediated Endocytosis Transition Between Fast And Slow Fiber Negative Regulation Of Caveolin-mediated Endocytosis Positive Regulation Of Cardiac Muscle Hypertrophy In Response To Stress Cytokinesis, Completion Of Separation Negative Regulation Of Transport Regulation Of Cardiac Muscle Hypertrophy In Response To Stress Calcineurin-NFAT Signaling Cascade Regulation Of Skeletal Muscle Adaptation Regulation Of Caveolin-mediated Endocytosis Positive Regulation Of NFAT Protein Import Into Nucleus Mitotic Cytokinetic Process Synaptic Transmission Mitotic Cell Cycle Process Regulation Of Clathrin-mediated Endocytosis Mitotic Cell Cycle Inositol Phosphate-mediated Signaling Positive Regulation Of Cardiac Muscle Hypertrophy Cell-cell Signaling Cell Separation After Cytokinesis Negative Regulation Of Receptor-mediated Endocytosis Lipoprotein Transport Skeletal Muscle Fiber Development Cell Cycle Process Myotube Cell Development Regulation Of Cardiac Muscle Hypertrophy Response To Amphetamine Negative Regulation Of Insulin Secretion Positive Regulation Of Protein Tyrosine Kinase Activity Positive Regulation Of Transcription Factor Import Into Nucleus Cell Cycle Negative Regulation Of Peptide Secretion Protein Transport Mitotic Cytokinesis Negative Regulation Of Endocytosis Establishment Of Protein Localization Muscle Fiber Development Response To Amine Cellular Response To Drug Myotube Differentiation Cellular Response To Glucose Stimulus Regulation Of Protein Tyrosine Kinase Activity Negative Regulation Of Hormone Secretion Regulation Of Excitatory Postsynaptic Membrane Potential Cellular Glucose Homeostasis Regulation Of Postsynaptic Membrane Potential Cellular Response To Carbohydrate Stimulus Protein Localization Multicellular Organismal Response To Stress Regulation Of Transcription Factor Import Into Nucleus
Tagcloud ?		adenocarcinoma chip coding cre dt ductal fresh g12d intraepithelial kras lincrna1611 lncrnas lsl neoplasia operation pan pancreatic panin pca pdac pdx profilings r172h resected rnas sh tissues tp53 weak
Tagcloud (Difference) ?		adenocarcinoma chip coding cre dt ductal fresh g12d intraepithelial kras lincrna1611 lncrnas lsl neoplasia operation pan pancreatic panin pca pdac pdx profilings r172h resected rnas sh tissues tp53 weak
Tagcloud (Intersection) ?