ATP2B4

Gene Name		ATPase, Ca++ transporting, plasma membrane 4
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Gene Ontology Annotations	Cellular Component	Plasma Membrane Integral Component Of Plasma Membrane Caveola Membrane Z Disc T-tubule Protein Complex
	Molecular Function	Calcium-transporting ATPase Activity Protein Binding Calmodulin Binding ATP Binding Sodium Channel Regulator Activity Protein Phosphatase 2B Binding Nitric-oxide Synthase Inhibitor Activity Metal Ion Binding Nitric-oxide Synthase Binding Scaffold Protein Binding
	Biological Process	Regulation Of Transcription From RNA Polymerase II Promoter Cellular Calcium Ion Homeostasis Blood Coagulation Metabolic Process Negative Regulation Of Nitric Oxide Mediated Signal Transduction Positive Regulation Of Peptidyl-serine Phosphorylation Ion Transmembrane Transport Negative Regulation Of Nitric Oxide Biosynthetic Process Negative Regulation Of Nitric-oxide Synthase Activity Response To Hydrostatic Pressure Calcium Ion Homeostasis Transmembrane Transport Calcium Ion Transmembrane Transport Negative Regulation Of Calcineurin-NFAT Signaling Cascade Cellular Response To Epinephrine Stimulus Calcium Ion Import Across Plasma Membrane Negative Regulation Of The Force Of Heart Contraction Negative Regulation Of Arginine Catabolic Process Negative Regulation Of Adrenergic Receptor Signaling Pathway Involved In Heart Process Negative Regulation Of Peptidyl-cysteine S-nitrosylation Regulation Of Sodium Ion Transmembrane Transport Negative Regulation Of Cardiac Muscle Hypertrophy In Response To Stress Negative Regulation Of Citrulline Biosynthetic Process Positive Regulation Of CAMP-dependent Protein Kinase Activity
Pathways		Ion transport by P-type ATPases Ion channel transport Platelet homeostasis Reduction of cytosolic Ca++ levels Platelet calcium homeostasis
Drugs
Diseases
GWAS		Breast size ( 22747683) Malaria ( 22895189) Mean corpuscular hemoglobin concentration ( 23263863)
Protein-protein Interactions		11 interactors: CASK CD22 DLG1 DLG2 DLG3 DLG4 ERBB2IP NOS1 PPP3CA RASSF1 SRC
Entrez ID		493
HPRD ID		00159
Ensembl ID		ENSG00000058668
Uniprot IDs		P23634
PDB IDs		1CFF 2KNE
Enriched GO Terms of Interacting Partners?		Receptor Localization To Synapse Nucleotide Phosphorylation Protein Localization To Synapse Establishment Or Maintenance Of Apical/basal Cell Polarity Receptor Clustering Establishment Or Maintenance Of Epithelial Cell Apical/basal Polarity Establishment Or Maintenance Of Cell Polarity Nucleotide Metabolic Process Synaptic Transmission Cell Adhesion Nucleobase-containing Small Molecule Metabolic Process Positive Regulation Of Transport Cellular Protein Localization Protein Localization To Membrane Axon Guidance Membrane Organization Negative Regulation Of Hydrolase Activity Regulation Of Ion Transmembrane Transport Cell-cell Signaling Organophosphate Metabolic Process Cortical Actin Cytoskeleton Organization Axonogenesis Phosphorylation Phosphate-containing Compound Metabolic Process Cortical Cytoskeleton Organization Signaling Protein Localization Positive Regulation Of Ion Transport Axon Development Cell Communication Negative Regulation Of Cell Adhesion Cell Morphogenesis Involved In Neuron Differentiation Chemotaxis Regulation Of Sodium Ion Transmembrane Transport Regulation Of Ion Transport Negative Regulation Of Cell-matrix Adhesion Locomotion Neuron Projection Morphogenesis Cell Cycle Regulation Of Membrane Potential Cell Morphogenesis Involved In Differentiation Positive Regulation Of Metabolic Process Negative Regulation Of Cell-substrate Adhesion Small Molecule Metabolic Process Anatomical Structure Development Regulation Of Catalytic Activity Myotube Differentiation Regulation Of Phosphorus Metabolic Process Cellular Localization Regulation Of Synaptic Transmission
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