ATR and FANCD2

Number of citations of the paper that reports this interaction (PMID 16943440)
40

Data Source:
BioGRID (enzymatic study)

		ATR	FANCD2
Gene Name		ATR serine/threonine kinase	Fanconi anemia, complementation group D2
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	XY Body Nucleoplasm Chromosome Golgi Apparatus PML Body	Condensed Chromosome Nucleoplasm Golgi Apparatus Intracellular Membrane-bounded Organelle
	Molecular Function	DNA Binding Protein Kinase Activity Protein Serine/threonine Kinase Activity Protein Binding ATP Binding MutLalpha Complex Binding MutSalpha Complex Binding Protein Dimerization Activity	Protein Binding DNA Polymerase Binding
	Biological Process	DNA Damage Checkpoint Double-strand Break Repair Via Homologous Recombination DNA Replication DNA Repair Cellular Response To DNA Damage Stimulus Cell Cycle Multicellular Organismal Development Negative Regulation Of DNA Replication Peptidyl-serine Phosphorylation Cellular Response To Heat Cellular Response To UV Response To Drug Regulation Of Protein Binding Positive Regulation Of DNA Damage Response, Signal Transduction By P53 Class Mediator Protein Autophosphorylation Cellular Response To Gamma Radiation Replicative Senescence Regulation Of Cellular Response To Heat	DNA Repair Synapsis Gamete Generation Response To Gamma Radiation
Pathways		Fanconi Anemia pathway G2/M DNA damage checkpoint G2/M Checkpoints Meiotic synapsis Regulation of HSF1-mediated heat shock response Cellular response to heat stress Regulation of the Fanconi anemia pathway Activation of ATR in response to replication stress Cell Cycle Checkpoints	Fanconi Anemia pathway Regulation of the Fanconi anemia pathway
Drugs
Diseases
GWAS
Protein-Protein Interactions		47 interactors: AATF ABL1 AP1B1 AP2A2 ARHGEF1 ATM ATRIP BLM BRCA1 BRCA2 CDKN2C CEP164 CHD4 CHEK1 CHEK2 CLSPN CREB1 DCLRE1C DTL E2F1 E4F1 EEF1E1 EP300 FANCA FANCD2 FLT1 H2AFX KDR LIG4 MCM2 MRE11A MSH2 NBN PA2G4 PIK3CA POLD1 POLN PPP2R2A PTS RAD17 RHEB TP53 TREX1 UPF1 VPRBP XPA XRCC5	20 interactors: ATM ATR BLM BRCA1 BRCA2 FANCC FANCE FANCI FANCL MEN1 MRE11A NBN PCNA RAD51 TERF1 TNFRSF1A TNFRSF1B TNKS UBB USP1
Entrez ID		545	2177
HPRD ID		08369	01968
Ensembl ID		ENSG00000175054	ENSG00000144554
Uniprot IDs		Q13535	Q9BXW9
PDB IDs
Enriched GO Terms of Interacting Partners?		Cellular Response To DNA Damage Stimulus DNA Repair DNA Metabolic Process Cellular Response To Stress Cell Cycle Process Cell Cycle DNA Damage Checkpoint Double-strand Break Repair DNA Replication Cell Cycle Checkpoint DNA Recombination Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Nucleobase-containing Compound Metabolic Process Cellular Nitrogen Compound Metabolic Process Response To Stress Regulation Of Cell Cycle Response To Ionizing Radiation Mitotic Cell Cycle Nitrogen Compound Metabolic Process Response To Radiation Negative Regulation Of Cell Cycle Mitotic Cell Cycle Process Regulation Of Mitotic Cell Cycle G2 DNA Damage Checkpoint Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage Cellular Response To Stimulus Intrinsic Apoptotic Signaling Pathway Chromosome Organization Negative Regulation Of Mitotic Cell Cycle Response To Abiotic Stimulus Apoptotic Signaling Pathway Double-strand Break Repair Via Homologous Recombination Recombinational Repair Organelle Organization Response To Stimulus Cell Cycle Arrest Negative Regulation Of DNA Metabolic Process Response To X-ray Mitotic DNA Integrity Checkpoint Mitotic Cell Cycle Checkpoint Signal Transduction By P53 Class Mediator Telomere Maintenance Cellular Macromolecule Biosynthetic Process Cellular Metabolic Process Macromolecule Biosynthetic Process Negative Regulation Of DNA Replication B Cell Activation Signal Transduction In Response To DNA Damage Biosynthetic Process	Cellular Response To DNA Damage Stimulus DNA Repair DNA Metabolic Process Cellular Response To Stress Regulation Of DNA Replication Double-strand Break Repair Via Homologous Recombination Recombinational Repair Cell Cycle DNA Recombination Cell Cycle Process Response To Stress Double-strand Break Repair Negative Regulation Of DNA Replication Cell Cycle Checkpoint Response To Ionizing Radiation DNA Damage Checkpoint Telomere Maintenance DNA Replication Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process G2 DNA Damage Checkpoint Negative Regulation Of DNA Metabolic Process Regulation Of Cellular Protein Metabolic Process Nucleobase-containing Compound Metabolic Process Cellular Response To Stimulus Nitrogen Compound Metabolic Process Response To Stimulus Mitotic G2 DNA Damage Checkpoint Regulation Of Protein Metabolic Process Response To Radiation Negative Regulation Of Cell Cycle Cellular Nitrogen Compound Metabolic Process Mitotic Cell Cycle Checkpoint Response To Abiotic Stimulus DNA Damage Response, Signal Transduction By P53 Class Mediator Intrinsic Apoptotic Signaling Pathway Apoptotic Signaling Pathway Positive Regulation Of Cellular Metabolic Process Signal Transduction In Response To DNA Damage Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage Mitotic DNA Damage Checkpoint Mitotic DNA Integrity Checkpoint Negative Regulation Of Mitotic Cell Cycle Regulation Of Cell Cycle Regulation Of Mitotic Cell Cycle Signal Transduction By P53 Class Mediator Mitotic Cell Cycle Process Chromosome Organization Regulation Of Response To DNA Damage Stimulus Mitotic Cell Cycle
Tagcloud ?		activators breakage broad chromatin chromosome comprises concept defect discuss emerging exert heterochromatin hybrid inherited mediate member modulating mr numerous observations remodelling repair retardation seems segregation snf2 somehow thalaessemia xnp	10ng agreed atr bard1 belonged biosynthetic biphenyls brca2 dioxin figf hands immunoblots impulses kcnma1 lactational mycn ndl neurobiological npy4r ontology operator6 pcbs performances projection rad51 scn1a summation transcriptomic validating
Tagcloud (Difference) ?		activators breakage broad chromatin chromosome comprises concept defect discuss emerging exert heterochromatin hybrid inherited mediate member modulating mr numerous observations remodelling repair retardation seems segregation snf2 somehow thalaessemia xnp	10ng agreed bard1 belonged biosynthetic biphenyls brca2 dioxin figf hands immunoblots impulses kcnma1 lactational mycn ndl neurobiological npy4r ontology operator6 pcbs performances projection rad51 scn1a summation transcriptomic validating
Tagcloud (Intersection) ?		atr