ATR and CEP164

Number of citations of the paper that reports this interaction (PMID 18283122)
18

Data Source:
BioGRID (pull down, enzymatic study)

		ATR	CEP164
Gene Name		ATR serine/threonine kinase	centrosomal protein 164kDa
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	XY Body Nucleoplasm Chromosome Golgi Apparatus PML Body	Extracellular Space Nucleoplasm Centrosome Centriole Cytosol Ciliary Transition Fiber
	Molecular Function	DNA Binding Protein Kinase Activity Protein Serine/threonine Kinase Activity Protein Binding ATP Binding MutLalpha Complex Binding MutSalpha Complex Binding Protein Dimerization Activity	Protein Binding
	Biological Process	DNA Damage Checkpoint Double-strand Break Repair Via Homologous Recombination DNA Replication DNA Repair Cellular Response To DNA Damage Stimulus Cell Cycle Multicellular Organismal Development Negative Regulation Of DNA Replication Peptidyl-serine Phosphorylation Cellular Response To Heat Cellular Response To UV Response To Drug Regulation Of Protein Binding Positive Regulation Of DNA Damage Response, Signal Transduction By P53 Class Mediator Protein Autophosphorylation Cellular Response To Gamma Radiation Replicative Senescence Regulation Of Cellular Response To Heat	G2/M Transition Of Mitotic Cell Cycle Mitotic Cell Cycle DNA Repair Organelle Organization Mitotic Nuclear Division Cilium Assembly Cell Division
Pathways		Fanconi Anemia pathway G2/M DNA damage checkpoint G2/M Checkpoints Meiotic synapsis Regulation of HSF1-mediated heat shock response Cellular response to heat stress Regulation of the Fanconi anemia pathway Activation of ATR in response to replication stress Cell Cycle Checkpoints	Organelle biogenesis and maintenance Loss of proteins required for interphase microtubule organizationÂ from the centrosome Loss of Nlp from mitotic centrosomes G2/M Transition Assembly of the primary cilium Centrosome maturation Regulation of PLK1 Activity at G2/M Transition Mitotic G2-G2/M phases Anchoring of the basal body to the plasma membrane Recruitment of mitotic centrosome proteins and complexes Cell Cycle, Mitotic
Drugs
Diseases
GWAS
Protein-Protein Interactions		47 interactors: AATF ABL1 AP1B1 AP2A2 ARHGEF1 ATM ATRIP BLM BRCA1 BRCA2 CDKN2C CEP164 CHD4 CHEK1 CHEK2 CLSPN CREB1 DCLRE1C DTL E2F1 E4F1 EEF1E1 EP300 FANCA FANCD2 FLT1 H2AFX KDR LIG4 MCM2 MRE11A MSH2 NBN PA2G4 PIK3CA POLD1 POLN PPP2R2A PTS RAD17 RHEB TP53 TREX1 UPF1 VPRBP XPA XRCC5	4 interactors: ATR ATRIP MAPK14 UBC
Entrez ID		545	22897
HPRD ID		08369	10854
Ensembl ID		ENSG00000175054	ENSG00000110274
Uniprot IDs		Q13535	Q9UPV0
PDB IDs
Enriched GO Terms of Interacting Partners?		Cellular Response To DNA Damage Stimulus DNA Repair DNA Metabolic Process Cellular Response To Stress Cell Cycle Process Cell Cycle DNA Damage Checkpoint Double-strand Break Repair DNA Replication Cell Cycle Checkpoint DNA Recombination Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Nucleobase-containing Compound Metabolic Process Cellular Nitrogen Compound Metabolic Process Response To Stress Regulation Of Cell Cycle Response To Ionizing Radiation Mitotic Cell Cycle Nitrogen Compound Metabolic Process Response To Radiation Negative Regulation Of Cell Cycle Mitotic Cell Cycle Process Regulation Of Mitotic Cell Cycle G2 DNA Damage Checkpoint Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage Cellular Response To Stimulus Intrinsic Apoptotic Signaling Pathway Chromosome Organization Negative Regulation Of Mitotic Cell Cycle Response To Abiotic Stimulus Apoptotic Signaling Pathway Double-strand Break Repair Via Homologous Recombination Recombinational Repair Organelle Organization Response To Stimulus Cell Cycle Arrest Negative Regulation Of DNA Metabolic Process Response To X-ray Mitotic DNA Integrity Checkpoint Mitotic Cell Cycle Checkpoint Signal Transduction By P53 Class Mediator Telomere Maintenance Cellular Macromolecule Biosynthetic Process Cellular Metabolic Process Macromolecule Biosynthetic Process Negative Regulation Of DNA Replication B Cell Activation Signal Transduction In Response To DNA Damage Biosynthetic Process	DNA Damage Checkpoint Cell Cycle Checkpoint Cellular Response To DNA Damage Stimulus Cell Cycle Process Cell Cycle Cellular Response To Stress Toll-like Receptor 5 Signaling Pathway Toll-like Receptor 10 Signaling Pathway Toll-like Receptor TLR6:TLR2 Signaling Pathway Toll-like Receptor TLR1:TLR2 Signaling Pathway Cellular Response To Ionizing Radiation Toll-like Receptor 2 Signaling Pathway Toll-like Receptor 9 Signaling Pathway TRIF-dependent Toll-like Receptor Signaling Pathway MyD88-independent Toll-like Receptor Signaling Pathway Toll-like Receptor 3 Signaling Pathway MyD88-dependent Toll-like Receptor Signaling Pathway Cell Aging DNA Repair Toll-like Receptor 4 Signaling Pathway Signal Transduction In Response To DNA Damage Toll-like Receptor Signaling Pathway Stress-activated MAPK Cascade Peptidyl-serine Phosphorylation Stress-activated Protein Kinase Signaling Cascade Positive Regulation Of Intracellular Signal Transduction P38MAPK Cascade Pattern Recognition Receptor Signaling Pathway Innate Immune Response-activating Signal Transduction Cellular Response To Radiation Activation Of MAPK Activity Activation Of Innate Immune Response Glucose Metabolic Process Response To Ionizing Radiation Negative Regulation Of Canonical Wnt Signaling Pathway DNA Metabolic Process Positive Regulation Of Innate Immune Response Response To Abiotic Stimulus Negative Regulation Of Wnt Signaling Pathway Pathogenesis Hexose Metabolic Process Response To Stress Neurotrophin TRK Receptor Signaling Pathway Positive Regulation Of MAP Kinase Activity Neurotrophin Signaling Pathway Regulation Of Canonical Wnt Signaling Pathway MAPK Cascade Cellular Macromolecule Biosynthetic Process Positive Regulation Of Signal Transduction Macromolecule Biosynthetic Process
Tagcloud ?		activators breakage broad chromatin chromosome comprises concept defect discuss emerging exert heterochromatin hybrid inherited mediate member modulating mr numerous observations remodelling repair retardation seems segregation snf2 somehow thalaessemia xnp	accessory align appendage appendages cby cenexin centriogenesis centriolar centriole centrioles centrosome chibby cilia cilium cnx coincident collaboration daughter dispensable distal dot foxj1 mother motile organelles precisely quiescent subdistal tracheal
Tagcloud (Difference) ?		activators breakage broad chromatin chromosome comprises concept defect discuss emerging exert heterochromatin hybrid inherited mediate member modulating mr numerous observations remodelling repair retardation seems segregation snf2 somehow thalaessemia xnp	accessory align appendage appendages cby cenexin centriogenesis centriolar centriole centrioles centrosome chibby cilia cilium cnx coincident collaboration daughter dispensable distal dot foxj1 mother motile organelles precisely quiescent subdistal tracheal
Tagcloud (Intersection) ?