AK3 and DAPK3

Number of citations of the paper that reports this interaction (PMID 21988832)
14

Data Source:
BioGRID (two hybrid)

		AK3	DAPK3
Gene Name		adenylate kinase 3	death-associated protein kinase 3
Image
Gene Ontology Annotations	Cellular Component	Mitochondrion Mitochondrial Matrix	Nucleus Cytoplasm PML Body Membrane Raft
	Molecular Function	Adenylate Kinase Activity ATP Binding GTP Binding Nucleoside Triphosphate Adenylate Kinase Activity	Protein Serine/threonine Kinase Activity Calmodulin-dependent Protein Kinase Activity Protein Binding ATP Binding Rho GTPase Binding Identical Protein Binding Protein Homodimerization Activity Leucine Zipper Domain Binding
	Biological Process	ADP Biosynthetic Process Blood Coagulation Phosphorylation AMP Metabolic Process GTP Metabolic Process ITP Metabolic Process UTP Metabolic Process	Cytokinesis Transcription, DNA-templated Regulation Of Transcription, DNA-templated Protein Phosphorylation Apoptotic Process Regulation Of Smooth Muscle Contraction Regulation Of Mitotic Nuclear Division Regulation Of Mitotic Cell Cycle Regulation Of Cell Shape Regulation Of Autophagy Chromatin Modification Negative Regulation Of Translation Neuron Differentiation Positive Regulation Of Cell Migration Intracellular Signal Transduction Regulation Of Apoptotic Process Positive Regulation Of Apoptotic Process Regulation Of Myosin II Filament Organization Protein Autophosphorylation Regulation Of Focal Adhesion Assembly Cellular Response To Interferon-gamma Positive Regulation Of Canonical Wnt Signaling Pathway Apoptotic Signaling Pathway Regulation Of Cell Motility Regulation Of Actin Cytoskeleton Reorganization Positive Regulation Of Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand
Pathways		Factors involved in megakaryocyte development and platelet production	Programmed Cell Death Role of DCC in regulating apoptosis Extrinsic Pathway
Drugs
Diseases
GWAS		Crohn's disease ( 22412388) Hematological parameters ( 19820697) Platelet counts ( 22139419 20139978)	Age-related macular degeneration ( 23326517)
Protein-Protein Interactions		3 interactors: APPBP2 DAPK3 ZDHHC17	15 interactors: AATF AK3 ATF4 CDKN1A CHEK2 DAXX GRB14 MDM2 MET NEDD4L PAWR PRKCZ RPL34 TCP10L TP53
Entrez ID		50808	1613
HPRD ID		12439	04478
Ensembl ID			ENSG00000167657
Uniprot IDs		Q7Z4Y4 Q9UIJ7	O43293
PDB IDs		1ZD8	1YRP 2J90 3BHY 3BQR
Enriched GO Terms of Interacting Partners?			Apoptotic Signaling Pathway Apoptotic Process Programmed Cell Death Cell Death Death Regulation Of Protein Metabolic Process Positive Regulation Of Protein Metabolic Process Signal Transduction Involved In DNA Damage Checkpoint Signal Transduction Involved In Cell Cycle Checkpoint Negative Regulation Of Cellular Metabolic Process Regulation Of Cell Death Signal Transduction In Response To DNA Damage Mitotic DNA Damage Checkpoint Mitotic DNA Integrity Checkpoint Positive Regulation Of Cellular Metabolic Process Positive Regulation Of Metabolic Process Negative Regulation Of Biosynthetic Process Response To Stress Enzyme Linked Receptor Protein Signaling Pathway Regulation Of Apoptotic Process Cellular Response To Growth Factor Stimulus Negative Regulation Of Cell Death Positive Regulation Of Programmed Cell Death Response To Growth Factor Positive Regulation Of Cell Death Regulation Of Gene Expression Regulation Of Nitrogen Compound Metabolic Process DNA Damage Checkpoint Positive Regulation Of Cellular Protein Metabolic Process Mitotic Cell Cycle Checkpoint Positive Regulation Of Protein Phosphorylation RNA Biosynthetic Process Signal Transduction Regulation Of Mitotic Cell Cycle Regulation Of Transcription, DNA-templated Regulation Of Transcription From RNA Polymerase II Promoter Intrinsic Apoptotic Signaling Pathway Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process DNA Damage Response, Signal Transduction By P53 Class Mediator Resulting In Cell Cycle Arrest Signal Transduction Involved In Mitotic G1 DNA Damage Checkpoint Regulation Of RNA Metabolic Process Cellular Response To UV Negative Regulation Of Gene Expression Positive Regulation Of Protein Kinase Activity Signaling Positive Regulation Of Phosphorylation Cellular Response To Extracellular Stimulus Cell Communication Positive Regulation Of Kinase Activity
Tagcloud ?			3d accelerated acinar acini actively augmented constitutive dcis depleted enlarged epistatic epithelia exerts gaps knockout lacks lentiviral morphogenesis mtorc1 oncomine polarity raptor shed spatio suppressive threonine uniquely utilizing vital
Tagcloud (Difference) ?			3d accelerated acinar acini actively augmented constitutive dcis depleted enlarged epistatic epithelia exerts gaps knockout lacks lentiviral morphogenesis mtorc1 oncomine polarity raptor shed spatio suppressive threonine uniquely utilizing vital
Tagcloud (Intersection) ?