DAPK3 and ATF4

Number of citations of the paper that reports this interaction (PMID 9488481)
41

Data Source:
HPRD (in vivo, in vitro)

		DAPK3	ATF4
Gene Name		death-associated protein kinase 3	activating transcription factor 4
Image
Gene Ontology Annotations	Cellular Component	Nucleus Cytoplasm PML Body Membrane Raft	Nucleus Nucleoplasm Cytoplasm Microtubule Organizing Center Dendrite Membrane Nuclear Periphery Neuron Projection Lewy Body Core ATF1-ATF4 Transcription Factor Complex
	Molecular Function	Protein Serine/threonine Kinase Activity Calmodulin-dependent Protein Kinase Activity Protein Binding ATP Binding Rho GTPase Binding Identical Protein Binding Protein Homodimerization Activity Leucine Zipper Domain Binding	RNA Polymerase II Core Promoter Proximal Region Sequence-specific DNA Binding Sequence-specific DNA Binding RNA Polymerase II Transcription Factor Activity Core Promoter Sequence-specific DNA Binding RNA Polymerase II Transcription Factor Binding Transcription Factor Activity RNA Polymerase II Core Promoter Proximal Region Sequence-specific DNA Binding Transcription Factor Activity Involved In Positive Regulation Of Transcription DNA Binding Sequence-specific DNA Binding Transcription Factor Activity Protein Binding Protein C-terminus Binding Sequence-specific DNA Binding Transcription Regulatory Region DNA Binding
	Biological Process	Cytokinesis Transcription, DNA-templated Regulation Of Transcription, DNA-templated Protein Phosphorylation Apoptotic Process Regulation Of Smooth Muscle Contraction Regulation Of Mitotic Nuclear Division Regulation Of Mitotic Cell Cycle Regulation Of Cell Shape Regulation Of Autophagy Chromatin Modification Negative Regulation Of Translation Neuron Differentiation Positive Regulation Of Cell Migration Intracellular Signal Transduction Regulation Of Apoptotic Process Positive Regulation Of Apoptotic Process Regulation Of Myosin II Filament Organization Protein Autophosphorylation Regulation Of Focal Adhesion Assembly Cellular Response To Interferon-gamma Positive Regulation Of Canonical Wnt Signaling Pathway Apoptotic Signaling Pathway Regulation Of Cell Motility Regulation Of Actin Cytoskeleton Reorganization Positive Regulation Of Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand	Gluconeogenesis Regulation Of Transcription, DNA-templated Transcription From RNA Polymerase II Promoter Cellular Amino Acid Metabolic Process Activation Of Signaling Protein Activity Involved In Unfolded Protein Response Gamma-aminobutyric Acid Signaling Pathway Positive Regulation Vascular Endothelial Growth Factor Production Endoplasmic Reticulum Unfolded Protein Response Circadian Regulation Of Gene Expression Response To Endoplasmic Reticulum Stress Positive Regulation Of Transcription From RNA Polymerase II Promoter In Response To Oxidative Stress Cellular Response To Glucose Starvation Positive Regulation Of Apoptotic Process Negative Regulation Of Potassium Ion Transport Positive Regulation Of Neuron Apoptotic Process Cellular Protein Metabolic Process Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription From RNA Polymerase I Promoter Positive Regulation Of Transcription From RNA Polymerase II Promoter Intrinsic Apoptotic Signaling Pathway In Response To Endoplasmic Reticulum Stress Negative Regulation Of Oxidative Stress-induced Neuron Death Positive Regulation Of Transcription From RNA Polymerase II Promoter In Response To Endoplasmic Reticulum Stress
Pathways		Programmed Cell Death Role of DCC in regulating apoptosis Extrinsic Pathway	ATF4 activates genes PERK regulates gene expression ATF6-alpha activates chaperones ATF6-alpha activates chaperone genes Unfolded Protein Response (UPR)
Drugs
Diseases
GWAS		Age-related macular degeneration ( 23326517)	Inflammatory bowel disease ( 23128233)
Protein-Protein Interactions		15 interactors: AATF AK3 ATF4 CDKN1A CHEK2 DAXX GRB14 MDM2 MET NEDD4L PAWR PRKCZ RPL34 TCP10L TP53	65 interactors: APH1A APP ASB7 ATF2 ATF3 BATF BATF2 BATF3 BFSP2 BTRC CCDC106 CEBPA CEBPB CEBPE CEBPG CKAP4 CREB3 CREBZF DAPK3 DDIT3 DISC1 EGLN3 FOS FOSL1 GABBR2 GCC1 GOLGA1 GOLGA8EP GOLGA8F GPS2 GTF2A1L GTF2B GTF2F2 HAUS7 HK3 JUN JUNB KAT2B LDOC1 LMNB1 MAF MAFB MAP2K7 MDM2 MPZL2 NDC80 NEK6 NFE2 NFE2L1 NFE2L2 NFKBIA POLR2C PTCD3 REPS1 RPS6 SNAP29 SRA1 TBP TGM2 TREX2 TRIB3 TRIM24 TTR ZNF212 ZNF226
Entrez ID		1613	468
HPRD ID		04478	06817
Ensembl ID		ENSG00000167657	ENSG00000128272
Uniprot IDs		O43293	P18848 Q96AQ3
PDB IDs		1YRP 2J90 3BHY 3BQR	1CI6
Enriched GO Terms of Interacting Partners?		Apoptotic Signaling Pathway Apoptotic Process Programmed Cell Death Cell Death Death Regulation Of Protein Metabolic Process Positive Regulation Of Protein Metabolic Process Signal Transduction Involved In DNA Damage Checkpoint Signal Transduction Involved In Cell Cycle Checkpoint Negative Regulation Of Cellular Metabolic Process Regulation Of Cell Death Signal Transduction In Response To DNA Damage Mitotic DNA Damage Checkpoint Mitotic DNA Integrity Checkpoint Positive Regulation Of Cellular Metabolic Process Positive Regulation Of Metabolic Process Negative Regulation Of Biosynthetic Process Response To Stress Enzyme Linked Receptor Protein Signaling Pathway Regulation Of Apoptotic Process Cellular Response To Growth Factor Stimulus Negative Regulation Of Cell Death Positive Regulation Of Programmed Cell Death Response To Growth Factor Positive Regulation Of Cell Death Regulation Of Gene Expression Regulation Of Nitrogen Compound Metabolic Process DNA Damage Checkpoint Positive Regulation Of Cellular Protein Metabolic Process Mitotic Cell Cycle Checkpoint Positive Regulation Of Protein Phosphorylation RNA Biosynthetic Process Signal Transduction Regulation Of Mitotic Cell Cycle Regulation Of Transcription, DNA-templated Regulation Of Transcription From RNA Polymerase II Promoter Intrinsic Apoptotic Signaling Pathway Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process DNA Damage Response, Signal Transduction By P53 Class Mediator Resulting In Cell Cycle Arrest Signal Transduction Involved In Mitotic G1 DNA Damage Checkpoint Regulation Of RNA Metabolic Process Cellular Response To UV Negative Regulation Of Gene Expression Positive Regulation Of Protein Kinase Activity Signaling Positive Regulation Of Phosphorylation Cellular Response To Extracellular Stimulus Cell Communication Positive Regulation Of Kinase Activity	Transcription From RNA Polymerase II Promoter RNA Biosynthetic Process Transcription, DNA-templated RNA Metabolic Process Gene Expression Regulation Of RNA Biosynthetic Process Regulation Of Transcription From RNA Polymerase II Promoter Regulation Of RNA Metabolic Process Positive Regulation Of Gene Expression Regulation Of Transcription, DNA-templated Regulation Of Nucleic Acid-templated Transcription Regulation Of Gene Expression Cellular Macromolecule Biosynthetic Process Regulation Of Nitrogen Compound Metabolic Process Macromolecule Biosynthetic Process Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Cellular Biosynthetic Process Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Cellular Metabolic Process Heterocycle Metabolic Process Nucleobase-containing Compound Metabolic Process Regulation Of Metabolic Process Cellular Aromatic Compound Metabolic Process Positive Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of Metabolic Process Cellular Nitrogen Compound Metabolic Process Biosynthetic Process Nitrogen Compound Metabolic Process Cellular Response To Stress Myeloid Cell Differentiation Leukocyte Differentiation Cellular Metabolic Process Response To Stress Apoptotic Process Cellular Response To Organic Substance Negative Regulation Of Biosynthetic Process Organ Development Myeloid Leukocyte Differentiation Defense Response Programmed Cell Death Immune System Process Response To Stimulus Cell Death Death Hemopoiesis Response To External Stimulus Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of RNA Biosynthetic Process Viral Process Regulation Of Sequence-specific DNA Binding Transcription Factor Activity
Tagcloud ?		3d accelerated acinar acini actively augmented constitutive dcis depleted enlarged epistatic epithelia exerts gaps knockout lacks lentiviral morphogenesis mtorc1 oncomine polarity raptor shed spatio suppressive threonine uniquely utilizing vital	activates anticancer attenuated autophagy cebpb chip ddit4 depletion effectively elusive exo genomic greatly largely mitochondria mtorc1 nude pad pan perturbation potentials remain resolution responsive sesn2 triple unveiled xenograft yw3
Tagcloud (Difference) ?		3d accelerated acinar acini actively augmented constitutive dcis depleted enlarged epistatic epithelia exerts gaps knockout lacks lentiviral morphogenesis oncomine polarity raptor shed spatio suppressive threonine uniquely utilizing vital	activates anticancer attenuated autophagy cebpb chip ddit4 depletion effectively elusive exo genomic greatly largely mitochondria nude pad pan perturbation potentials remain resolution responsive sesn2 triple unveiled xenograft yw3
Tagcloud (Intersection) ?		mtorc1