DAPK3 and RPL34

Number of citations of the paper that reports this interaction (PMID 21988832)
14

Data Source:
BioGRID (two hybrid)

		DAPK3	RPL34
Gene Name		death-associated protein kinase 3	ribosomal protein L34
Image
Gene Ontology Annotations	Cellular Component	Nucleus Cytoplasm PML Body Membrane Raft	Nucleolus Cytoplasm Cytosol Cytosolic Large Ribosomal Subunit Extracellular Vesicular Exosome
	Molecular Function	Protein Serine/threonine Kinase Activity Calmodulin-dependent Protein Kinase Activity Protein Binding ATP Binding Rho GTPase Binding Identical Protein Binding Protein Homodimerization Activity Leucine Zipper Domain Binding	RNA Binding Structural Constituent Of Ribosome
	Biological Process	Cytokinesis Transcription, DNA-templated Regulation Of Transcription, DNA-templated Protein Phosphorylation Apoptotic Process Regulation Of Smooth Muscle Contraction Regulation Of Mitotic Nuclear Division Regulation Of Mitotic Cell Cycle Regulation Of Cell Shape Regulation Of Autophagy Chromatin Modification Negative Regulation Of Translation Neuron Differentiation Positive Regulation Of Cell Migration Intracellular Signal Transduction Regulation Of Apoptotic Process Positive Regulation Of Apoptotic Process Regulation Of Myosin II Filament Organization Protein Autophosphorylation Regulation Of Focal Adhesion Assembly Cellular Response To Interferon-gamma Positive Regulation Of Canonical Wnt Signaling Pathway Apoptotic Signaling Pathway Regulation Of Cell Motility Regulation Of Actin Cytoskeleton Reorganization Positive Regulation Of Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand	Nuclear-transcribed MRNA Catabolic Process, Nonsense-mediated Decay Translation Translational Initiation Translational Elongation Translational Termination SRP-dependent Cotranslational Protein Targeting To Membrane Gene Expression Viral Process Viral Life Cycle Viral Transcription Cellular Protein Metabolic Process
Pathways		Programmed Cell Death Role of DCC in regulating apoptosis Extrinsic Pathway	Nonsense-Mediated Decay (NMD) Translation SRP-dependent cotranslational protein targeting to membrane Eukaryotic Translation Termination Peptide chain elongation Influenza Infection Viral mRNA Translation L13a-mediated translational silencing of Ceruloplasmin expression Influenza Life Cycle Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) Influenza Viral RNA Transcription and Replication GTP hydrolysis and joining of the 60S ribosomal subunit Eukaryotic Translation Initiation Formation of a pool of free 40S subunits Eukaryotic Translation Elongation Cap-dependent Translation Initiation Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)
Drugs
Diseases
GWAS		Age-related macular degeneration ( 23326517)
Protein-Protein Interactions		15 interactors: AATF AK3 ATF4 CDKN1A CHEK2 DAXX GRB14 MDM2 MET NEDD4L PAWR PRKCZ RPL34 TCP10L TP53	5 interactors: APP CDK4 CDK5 DAPK3 MAX
Entrez ID		1613	6164
HPRD ID		04478	17996
Ensembl ID		ENSG00000167657	ENSG00000109475
Uniprot IDs		O43293	P49207
PDB IDs		1YRP 2J90 3BHY 3BQR	3J3B
Enriched GO Terms of Interacting Partners?		Apoptotic Signaling Pathway Apoptotic Process Programmed Cell Death Cell Death Death Regulation Of Protein Metabolic Process Positive Regulation Of Protein Metabolic Process Signal Transduction Involved In DNA Damage Checkpoint Signal Transduction Involved In Cell Cycle Checkpoint Negative Regulation Of Cellular Metabolic Process Regulation Of Cell Death Signal Transduction In Response To DNA Damage Mitotic DNA Damage Checkpoint Mitotic DNA Integrity Checkpoint Positive Regulation Of Cellular Metabolic Process Positive Regulation Of Metabolic Process Negative Regulation Of Biosynthetic Process Response To Stress Enzyme Linked Receptor Protein Signaling Pathway Regulation Of Apoptotic Process Cellular Response To Growth Factor Stimulus Negative Regulation Of Cell Death Positive Regulation Of Programmed Cell Death Response To Growth Factor Positive Regulation Of Cell Death Regulation Of Gene Expression Regulation Of Nitrogen Compound Metabolic Process DNA Damage Checkpoint Positive Regulation Of Cellular Protein Metabolic Process Mitotic Cell Cycle Checkpoint Positive Regulation Of Protein Phosphorylation RNA Biosynthetic Process Signal Transduction Regulation Of Mitotic Cell Cycle Regulation Of Transcription, DNA-templated Regulation Of Transcription From RNA Polymerase II Promoter Intrinsic Apoptotic Signaling Pathway Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process DNA Damage Response, Signal Transduction By P53 Class Mediator Resulting In Cell Cycle Arrest Signal Transduction Involved In Mitotic G1 DNA Damage Checkpoint Regulation Of RNA Metabolic Process Cellular Response To UV Negative Regulation Of Gene Expression Positive Regulation Of Protein Kinase Activity Signaling Positive Regulation Of Phosphorylation Cellular Response To Extracellular Stimulus Cell Communication Positive Regulation Of Kinase Activity	Neuron Apoptotic Process Neuron Death Regulation Of Cell Cycle Process Positive Regulation Of G2/M Transition Of Mitotic Cell Cycle Regulation Of Cell Cycle Apoptotic Process Regulation Of Translation Programmed Cell Death Cell Death Death Regulation Of Actin Cytoskeleton Reorganization Regulation Of G2/M Transition Of Mitotic Cell Cycle Regulation Of Cell Cycle G2/M Phase Transition Protein Phosphorylation Regulation Of Mitotic Cell Cycle Positive Regulation Of Mitotic Cell Cycle Phase Transition Cell Division Positive Regulation Of Cell Cycle Phase Transition Posttranscriptional Regulation Of Gene Expression Visual Learning Response To Stress Visual Behavior Synapse Assembly Associative Learning Developmental Cell Growth Positive Regulation Of Apoptotic Process Positive Regulation Of Programmed Cell Death Positive Regulation Of Cell Death Regulation Of Cell Cycle Arrest System Development Phosphorylation Regulation Of Cellular Protein Metabolic Process Positive Regulation Of Mitotic Cell Cycle Regulation Of Receptor Activity Response To Wounding Regulation Of Cell Size Regulation Of Protein Kinase Activity Multicellular Organismal Development Learning Regulation Of Protein Metabolic Process Dendrite Development Regulation Of Kinase Activity Developmental Growth Involved In Morphogenesis Regulation Of Protein Binding Negative Regulation Of Cellular Protein Metabolic Process Cell Growth Regulation Of Gene Expression Anatomical Structure Development Synaptic Growth At Neuromuscular Junction Adult Behavior
Tagcloud ?		3d accelerated acinar acini actively augmented constitutive dcis depleted enlarged epistatic epithelia exerts gaps knockout lacks lentiviral morphogenesis mtorc1 oncomine polarity raptor shed spatio suppressive threonine uniquely utilizing vital
Tagcloud (Difference) ?		3d accelerated acinar acini actively augmented constitutive dcis depleted enlarged epistatic epithelia exerts gaps knockout lacks lentiviral morphogenesis mtorc1 oncomine polarity raptor shed spatio suppressive threonine uniquely utilizing vital
Tagcloud (Intersection) ?