DAPK3 and DAXX

Number of citations of the paper that reports this interaction (PMID 12917339)
20

Data Source:
BioGRID (affinity chromatography technology)
HPRD (in vivo)

		DAPK3	DAXX
Gene Name		death-associated protein kinase 3	death-domain associated protein
Image
Gene Ontology Annotations	Cellular Component	Nucleus Cytoplasm PML Body Membrane Raft	Chromosome, Centromeric Region Heterochromatin Nucleus Nucleolus Cytoplasm Cytosol PML Body SWI/SNF Superfamily-type Complex
	Molecular Function	Protein Serine/threonine Kinase Activity Calmodulin-dependent Protein Kinase Activity Protein Binding ATP Binding Rho GTPase Binding Identical Protein Binding Protein Homodimerization Activity Leucine Zipper Domain Binding	P53 Binding Transcription Corepressor Activity Receptor Signaling Protein Activity Protein Binding Transcription Factor Binding Enzyme Binding Protein Kinase Binding Protein Kinase Activator Activity Heat Shock Protein Binding Ubiquitin Protein Ligase Binding Histone Binding Protein Homodimerization Activity Protein N-terminus Binding Androgen Receptor Binding
	Biological Process	Cytokinesis Transcription, DNA-templated Regulation Of Transcription, DNA-templated Protein Phosphorylation Apoptotic Process Regulation Of Smooth Muscle Contraction Regulation Of Mitotic Nuclear Division Regulation Of Mitotic Cell Cycle Regulation Of Cell Shape Regulation Of Autophagy Chromatin Modification Negative Regulation Of Translation Neuron Differentiation Positive Regulation Of Cell Migration Intracellular Signal Transduction Regulation Of Apoptotic Process Positive Regulation Of Apoptotic Process Regulation Of Myosin II Filament Organization Protein Autophosphorylation Regulation Of Focal Adhesion Assembly Cellular Response To Interferon-gamma Positive Regulation Of Canonical Wnt Signaling Pathway Apoptotic Signaling Pathway Regulation Of Cell Motility Regulation Of Actin Cytoskeleton Reorganization Positive Regulation Of Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand	Mitotic Cytokinesis Positive Regulation Of Protein Phosphorylation Nucleosome Assembly Chromatin Remodeling Transcription, DNA-templated Regulation Of Transcription, DNA-templated Apoptotic Process Activation Of JUN Kinase Activity Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors Viral Process Androgen Receptor Signaling Pathway Regulation Of Protein Ubiquitination Positive Regulation Of Protein Kinase Activity Negative Regulation Of Transcription, DNA-templated Positive Regulation Of Neuron Death Positive Regulation Of Apoptotic Signaling Pathway
Pathways		Programmed Cell Death Role of DCC in regulating apoptosis Extrinsic Pathway
Drugs
Diseases
GWAS		Age-related macular degeneration ( 23326517)
Protein-Protein Interactions		15 interactors: AATF AK3 ATF4 CDKN1A CHEK2 DAXX GRB14 MDM2 MET NEDD4L PAWR PRKCZ RPL34 TCP10L TP53	82 interactors: AIRE AR ATM ATRX BTBD6 CA12 CALCOCO2 CARD9 CARM1 CBS CDCA7L CENPC CFLAR CREBBP DAPK3 DMAP1 DNMT1 ESRRG ETS1 FAM9B FANCA FAS FASLG FTH1 GOLGA2 H3F3A HABP4 HBA1 HDAC1 HDAC2 HDAC3 HIPK1 HIPK2 HIPK3 HIST1H3C HIST1H4F HIST4H4 HSF1 HSPB1 MAP3K5 MCRS1 MDM2 MST1 MX1 MYH11 NECAB2 NR3C1 PARK7 PAX3 PAX5 PBXIP1 PLAGL1 PML PRMT1 RASSF1 RPL13 SENP2 SERBP1 SLC2A4 SLC9A1 SNW1 SPN SPOP SSX2IP STAT3 STUB1 SUMO1 TCF3 TCF7L2 TGFB1 TGFB2 TGFBR2 TNFRSF1A TP53 TP63 TP73 TRAF3 TRIM21 TSG101 UBE2I USP7 WHSC1L1
Entrez ID		1613	1616
HPRD ID		04478	04424
Ensembl ID		ENSG00000167657	ENSG00000204209
Uniprot IDs		O43293	B4E1C1 F5ANJ6 F5ANJ7 Q53F85 Q9UER7
PDB IDs		1YRP 2J90 3BHY 3BQR	2KQS 2KZS 2KZU 4H9N 4H9O 4H9P 4H9Q 4H9R 4H9S 4HGA
Enriched GO Terms of Interacting Partners?		Apoptotic Signaling Pathway Apoptotic Process Programmed Cell Death Cell Death Death Regulation Of Protein Metabolic Process Positive Regulation Of Protein Metabolic Process Signal Transduction Involved In DNA Damage Checkpoint Signal Transduction Involved In Cell Cycle Checkpoint Negative Regulation Of Cellular Metabolic Process Regulation Of Cell Death Signal Transduction In Response To DNA Damage Mitotic DNA Damage Checkpoint Mitotic DNA Integrity Checkpoint Positive Regulation Of Cellular Metabolic Process Positive Regulation Of Metabolic Process Negative Regulation Of Biosynthetic Process Response To Stress Enzyme Linked Receptor Protein Signaling Pathway Regulation Of Apoptotic Process Cellular Response To Growth Factor Stimulus Negative Regulation Of Cell Death Positive Regulation Of Programmed Cell Death Response To Growth Factor Positive Regulation Of Cell Death Regulation Of Gene Expression Regulation Of Nitrogen Compound Metabolic Process DNA Damage Checkpoint Positive Regulation Of Cellular Protein Metabolic Process Mitotic Cell Cycle Checkpoint Positive Regulation Of Protein Phosphorylation RNA Biosynthetic Process Signal Transduction Regulation Of Mitotic Cell Cycle Regulation Of Transcription, DNA-templated Regulation Of Transcription From RNA Polymerase II Promoter Intrinsic Apoptotic Signaling Pathway Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process DNA Damage Response, Signal Transduction By P53 Class Mediator Resulting In Cell Cycle Arrest Signal Transduction Involved In Mitotic G1 DNA Damage Checkpoint Regulation Of RNA Metabolic Process Cellular Response To UV Negative Regulation Of Gene Expression Positive Regulation Of Protein Kinase Activity Signaling Positive Regulation Of Phosphorylation Cellular Response To Extracellular Stimulus Cell Communication Positive Regulation Of Kinase Activity	Regulation Of Gene Expression Negative Regulation Of Gene Expression Negative Regulation Of RNA Biosynthetic Process Negative Regulation Of Biosynthetic Process Regulation Of Transcription, DNA-templated Negative Regulation Of Transcription, DNA-templated Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Negative Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Metabolic Process Positive Regulation Of Cellular Metabolic Process Negative Regulation Of Cellular Metabolic Process Regulation Of Metabolic Process Response To Stress Regulation Of Nitrogen Compound Metabolic Process Regulation Of Cell Death Regulation Of Apoptotic Process Positive Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of Metabolic Process Cell Death Regulation Of Signal Transduction Death Apoptotic Process Regulation Of Protein Metabolic Process Response To Organic Substance Positive Regulation Of Gene Expression Chromatin Organization Regulation Of Transcription From RNA Polymerase II Promoter Programmed Cell Death Gene Expression Regulation Of Cell Proliferation Positive Regulation Of Macromolecule Biosynthetic Process RNA Biosynthetic Process Positive Regulation Of Transcription, DNA-templated Regulation Of Signaling Transcription, DNA-templated Cellular Response To Stress Cellular Aromatic Compound Metabolic Process Chromatin Modification Negative Regulation Of Transcription From RNA Polymerase II Promoter Nitrogen Compound Metabolic Process Regulation Of Cellular Protein Metabolic Process Regulation Of Cellular Process Response To Stimulus Chromosome Organization Organelle Organization Positive Regulation Of Cellular Biosynthetic Process Positive Regulation Of Protein Metabolic Process Nucleobase-containing Compound Metabolic Process Regulation Of Cell Cycle
Tagcloud ?		3d accelerated acinar acini actively augmented constitutive dcis depleted enlarged epistatic epithelia exerts gaps knockout lacks lentiviral morphogenesis mtorc1 oncomine polarity raptor shed spatio suppressive threonine uniquely utilizing vital	adaptor appear characterization convey death domains effector fadd far growing homologies insights isolation jun mammalian members mort necrosis represents rip seem share signals superfamily tnfr tradd traf traf1 transmit
Tagcloud (Difference) ?		3d accelerated acinar acini actively augmented constitutive dcis depleted enlarged epistatic epithelia exerts gaps knockout lacks lentiviral morphogenesis mtorc1 oncomine polarity raptor shed spatio suppressive threonine uniquely utilizing vital	adaptor appear characterization convey death domains effector fadd far growing homologies insights isolation jun mammalian members mort necrosis represents rip seem share signals superfamily tnfr tradd traf traf1 transmit
Tagcloud (Intersection) ?