NRCAM and CNTN2

Number of citations of the paper that reports this interaction (PMID 12139915)
13

Data Source:
BioGRID (pull down)
HPRD (in vitro)

		NRCAM	CNTN2
Gene Name		neuronal cell adhesion molecule	contactin 2 (axonal)
Image
Gene Ontology Annotations	Cellular Component	Plasma Membrane Integral Component Of Plasma Membrane External Side Of Plasma Membrane Neuron Projection Axon Initial Segment Synapse	Plasma Membrane Integral Component Of Plasma Membrane Voltage-gated Potassium Channel Complex Cell Surface Anchored Component Of Membrane Node Of Ranvier Neuronal Cell Body Myelin Sheath Juxtaparanode Region Of Axon Synapse
	Molecular Function	Protein Binding Ankyrin Binding Protein Binding Involved In Heterotypic Cell-cell Adhesion	Glycoprotein Binding Carbohydrate Binding Identical Protein Binding Protein Self-association
	Biological Process	Angiogenesis Neuron Migration Axonogenesis Axon Guidance Axonal Fasciculation Synapse Assembly Central Nervous System Development Protein Localization Single Organismal Cell-cell Adhesion Neuronal Action Potential Propagation Regulation Of Axon Extension Retinal Ganglion Cell Axon Guidance Heterotypic Cell-cell Adhesion Clustering Of Voltage-gated Sodium Channels Positive Regulation Of Neuron Differentiation	Microtubule Cytoskeleton Organization Cell Adhesion Axon Guidance Axonal Fasciculation Learning Adult Walking Behavior Positive Regulation Of Protein Processing Cerebral Cortex GABAergic Interneuron Migration Central Nervous System Myelination Regulation Of Axon Diameter Receptor Internalization Cellular Protein Localization Clustering Of Voltage-gated Potassium Channels Negative Regulation Of Neuron Differentiation Regulation Of Neuronal Synaptic Plasticity Regulation Of Astrocyte Differentiation Positive Regulation Of Adenosine Receptor Signaling Pathway Establishment Of Protein Localization To Juxtaparanode Region Of Axon Presynaptic Membrane Organization
Pathways		Interaction between L1 and Ankyrins Axon guidance Neurofascin interactions L1CAM interactions NrCAM interactions	NCAM1 interactions Axon guidance L1CAM interactions NrCAM interactions NCAM signaling for neurite out-growth
Drugs
Diseases
GWAS		Coffee consumption ( 21876539) Femoral neck bone geometry and menarche (age at onset) ( 23593202)
Protein-Protein Interactions		8 interactors: ANK2 CNTN2 HSPA12A LNX1 MACF1 MAGI3 NFASC PTPRB	16 interactors: CNTN1 CNTNAP2 CREBBP EGFR EP300 HDAC1 KAT2B L1CAM NCAN NFYB NRCAM SRF TAX1BP1 TAX1BP3 TUBG1 VAC14
Entrez ID		4897	6900
HPRD ID		07207	01826
Ensembl ID		ENSG00000091129	ENSG00000184144
Uniprot IDs		B7Z670 Q14CA1 Q92823	A1L3A3 Q02246
PDB IDs		1UEN 1UEY	2OM5
Enriched GO Terms of Interacting Partners?		Protein Localization To Juxtaparanode Region Of Axon Neuronal Ion Channel Clustering Paranodal Junction Assembly Myelination Axon Ensheathment Neuron Maturation Myelin Assembly Membrane Organization Axon Guidance Anatomical Structure Formation Involved In Morphogenesis Establishment Of Protein Localization To Plasma Membrane Establishment Of Protein Localization To Juxtaparanode Region Of Axon Protein Localization To T-tubule Anatomical Structure Morphogenesis Axonogenesis Cellular Protein Localization Protein Localization To M-band Positive Regulation Of Adenosine Receptor Signaling Pathway T-tubule Organization Cell-cell Junction Assembly Axon Development Cell Morphogenesis Involved In Neuron Differentiation Protein Localization To Endoplasmic Reticulum Chemotaxis Movement Of Cell Or Subcellular Component Neuron Projection Morphogenesis Clustering Of Voltage-gated Potassium Channels Generation Of Neurons Cell Maturation Protein Localization To Plasma Membrane Regulation Of Axonogenesis Protein Targeting To Membrane Neurogenesis Cell Morphogenesis Involved In Differentiation Membrane Depolarization During SA Node Cell Action Potential Cell Junction Assembly SA Node Cell Action Potential Neuron Projection Development Cell-cell Junction Organization Cell Projection Morphogenesis Clustering Of Voltage-gated Sodium Channels Regulation Of Axon Diameter Protein Localization Cell Part Morphogenesis Plasma Membrane Organization Posttranslational Protein Targeting To Membrane Regulation Of Cardiac Muscle Cell Membrane Potential Establishment Of Protein Localization To Membrane Cerebral Cortex GABAergic Interneuron Migration Atrial Cardiac Muscle Cell Action Potential	N-terminal Peptidyl-lysine Acetylation Notch Signaling Pathway N-terminal Protein Amino Acid Acetylation Neuron Projection Development N-terminal Protein Amino Acid Modification Viral Process Rhythmic Process Neuron Development Positive Regulation Of Gene Expression Neuron Differentiation Axon Guidance Cell Morphogenesis Involved In Differentiation Cell Projection Organization Cell Adhesion Anatomical Structure Morphogenesis Cell Development Positive Regulation Of Transcription, DNA-templated Axonogenesis Central Nervous System Development Cell Communication Axon Development Positive Regulation Of Macromolecule Biosynthetic Process Neuronal Ion Channel Clustering Cell Morphogenesis Involved In Neuron Differentiation Generation Of Neurons Chemotaxis Positive Regulation Of Transcription From RNA Polymerase II Promoter Response To Hypoxia Positive Regulation Of Cellular Biosynthetic Process Cell Morphogenesis Nervous System Development Neuron Projection Morphogenesis Regulation Of Type I Interferon Production Neurogenesis Histone Acetylation Eyelid Development In Camera-type Eye Embryo Development Internal Peptidyl-lysine Acetylation Peptidyl-lysine Acetylation Internal Protein Amino Acid Acetylation Regulation Of Androgen Receptor Signaling Pathway Protein Acetylation Locomotion Cell Differentiation Positive Regulation Of Metabolic Process Histone Modification Regulation Of Transcription From RNA Polymerase II Promoter In Response To Hypoxia Innate Immune Response Signaling Response To Stimulus
Tagcloud ?		affects clustering disorganization dorsal erbb2 erbb3 ganglion glaucoma gliomedin implicate littermates myelin myelination myocilin nav1 nerve nerves neurofascin nodal nodes null ocular ranvier root schwann sciatic sheath stimulates thickness	aff2 algorithm arpp21 bioinformatics cacna2d3 degs depthfirst differentially downloaded economic enormous enrichment exonlevel gbm glioblastoma gliomas gse9385 hist1h3a hub impair od oligodendroglioma omnibus ontology ppi proteinprotein shared society splicing
Tagcloud (Difference) ?		affects clustering disorganization dorsal erbb2 erbb3 ganglion glaucoma gliomedin implicate littermates myelin myelination myocilin nav1 nerve nerves neurofascin nodal nodes null ocular ranvier root schwann sciatic sheath stimulates thickness	aff2 algorithm arpp21 bioinformatics cacna2d3 degs depthfirst differentially downloaded economic enormous enrichment exonlevel gbm glioblastoma gliomas gse9385 hist1h3a hub impair od oligodendroglioma omnibus ontology ppi proteinprotein shared society splicing
Tagcloud (Intersection) ?