CNTN2 and CNTN1

Number of citations of the paper that reports this interaction (PMID 12139915)
13

Data Source:
BioGRID (pull down)
HPRD (in vitro)

		CNTN2	CNTN1
Gene Name		contactin 2 (axonal)	contactin 1
Image
Gene Ontology Annotations	Cellular Component	Plasma Membrane Integral Component Of Plasma Membrane Voltage-gated Potassium Channel Complex Cell Surface Anchored Component Of Membrane Node Of Ranvier Neuronal Cell Body Myelin Sheath Juxtaparanode Region Of Axon Synapse	Plasma Membrane Membrane Anchored Component Of Membrane Extracellular Vesicular Exosome
	Molecular Function	Glycoprotein Binding Carbohydrate Binding Identical Protein Binding Protein Self-association	Glycoprotein Binding Carbohydrate Binding
	Biological Process	Microtubule Cytoskeleton Organization Cell Adhesion Axon Guidance Axonal Fasciculation Learning Adult Walking Behavior Positive Regulation Of Protein Processing Cerebral Cortex GABAergic Interneuron Migration Central Nervous System Myelination Regulation Of Axon Diameter Receptor Internalization Cellular Protein Localization Clustering Of Voltage-gated Potassium Channels Negative Regulation Of Neuron Differentiation Regulation Of Neuronal Synaptic Plasticity Regulation Of Astrocyte Differentiation Positive Regulation Of Adenosine Receptor Signaling Pathway Establishment Of Protein Localization To Juxtaparanode Region Of Axon Presynaptic Membrane Organization	Cell Adhesion Notch Signaling Pathway Axon Guidance Positive Regulation Of Gene Expression Positive Regulation Of Sodium Ion Transport Positive Regulation Of Neuron Projection Development Cerebellum Development
Pathways		NCAM1 interactions Axon guidance L1CAM interactions NrCAM interactions NCAM signaling for neurite out-growth	Signaling by NOTCH1 HD Domain Mutants in Cancer Axon guidance Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer Signaling by NOTCH L1CAM interactions NOTCH2 Activation and Transmission of Signal to the Nucleus Activated NOTCH1 Transmits Signal to the Nucleus Signaling by NOTCH1 t(7;9)(NOTCH1:M1580_K2555) Translocation Mutant Signaling by NOTCH2 Neurofascin interactions Signaling by NOTCH1 Signaling by NOTCH1 PEST Domain Mutants in Cancer Signaling by NOTCH1 in Cancer FBXW7 Mutants and NOTCH1 in Cancer
Drugs
Diseases
GWAS			Protein quantitative trait loci ( 18464913)
Protein-Protein Interactions		16 interactors: CNTN1 CNTNAP2 CREBBP EGFR EP300 HDAC1 KAT2B L1CAM NCAN NFYB NRCAM SRF TAX1BP1 TAX1BP3 TUBG1 VAC14	12 interactors: CNTN2 FYN L1CAM MAPK6 NOTCH1 NOTCH2 PPP1CA PRNP PTPRB SCNN1B TNC TNR
Entrez ID		6900	1272
HPRD ID		01826	07189
Ensembl ID		ENSG00000184144	ENSG00000018236
Uniprot IDs		A1L3A3 Q02246	Q12860
PDB IDs		2OM5	2EE2 3S97
Enriched GO Terms of Interacting Partners?		N-terminal Peptidyl-lysine Acetylation Notch Signaling Pathway N-terminal Protein Amino Acid Acetylation Neuron Projection Development N-terminal Protein Amino Acid Modification Viral Process Rhythmic Process Neuron Development Positive Regulation Of Gene Expression Neuron Differentiation Axon Guidance Cell Morphogenesis Involved In Differentiation Cell Projection Organization Cell Adhesion Anatomical Structure Morphogenesis Cell Development Positive Regulation Of Transcription, DNA-templated Axonogenesis Central Nervous System Development Cell Communication Axon Development Positive Regulation Of Macromolecule Biosynthetic Process Neuronal Ion Channel Clustering Cell Morphogenesis Involved In Neuron Differentiation Generation Of Neurons Chemotaxis Positive Regulation Of Transcription From RNA Polymerase II Promoter Response To Hypoxia Positive Regulation Of Cellular Biosynthetic Process Cell Morphogenesis Nervous System Development Neuron Projection Morphogenesis Regulation Of Type I Interferon Production Neurogenesis Histone Acetylation Eyelid Development In Camera-type Eye Embryo Development Internal Peptidyl-lysine Acetylation Peptidyl-lysine Acetylation Internal Protein Amino Acid Acetylation Regulation Of Androgen Receptor Signaling Pathway Protein Acetylation Locomotion Cell Differentiation Positive Regulation Of Metabolic Process Histone Modification Regulation Of Transcription From RNA Polymerase II Promoter In Response To Hypoxia Innate Immune Response Signaling Response To Stimulus	Axon Development Anatomical Structure Morphogenesis Response To External Stimulus Neuron Projection Development Axonogenesis Neuron Development Cell Morphogenesis Involved In Neuron Differentiation Regulation Of Cell Adhesion Neuron Projection Morphogenesis Neuron Differentiation Cell Projection Organization Cell Development Cell Morphogenesis Involved In Differentiation Axon Guidance System Development Cell Projection Morphogenesis Cell Part Morphogenesis Negative Regulation Of Cell Adhesion Nervous System Development Generation Of Neurons Response To Stimulus Neurogenesis Multicellular Organismal Development Cell Morphogenesis Anatomical Structure Development Response To Growth Factor Chemotaxis Learning Or Memory Interleukin-4 Secretion Notch Signaling Involved In Heart Development Pulmonary Valve Morphogenesis Cognition Locomotion Interleukin-4 Production Positive Regulation Of Signal Transduction Developmental Process Organ Development Regulation Of Signaling Regulation Of Cell-cell Adhesion Cell Migration Response To Ethanol Regulation Of Cell Proliferation Movement Of Cell Or Subcellular Component Learning Cell Motility Forebrain Development Cell Differentiation Single-organism Behavior Notch Receptor Processing Regulation Of Cell Morphogenesis
Tagcloud ?		aff2 algorithm arpp21 bioinformatics cacna2d3 degs depthfirst differentially downloaded economic enormous enrichment exonlevel gbm glioblastoma gliomas gse9385 hist1h3a hub impair od oligodendroglioma omnibus ontology ppi proteinprotein shared society splicing	axin2 axonogenesis coding dendritogenesis interplay inverse maintaining maturing microrna micrornas mrnas ncam1 negr1 neurite neurotrophin nrxn1 ontology orchestrated prkcb pruning represented respective rnas sh2b3 synaptogenesis temporally tightly transcriptome verification
Tagcloud (Difference) ?		aff2 algorithm arpp21 bioinformatics cacna2d3 degs depthfirst differentially downloaded economic enormous enrichment exonlevel gbm glioblastoma gliomas gse9385 hist1h3a hub impair od oligodendroglioma omnibus ppi proteinprotein shared society splicing	axin2 axonogenesis coding dendritogenesis interplay inverse maintaining maturing microrna micrornas mrnas ncam1 negr1 neurite neurotrophin nrxn1 orchestrated prkcb pruning represented respective rnas sh2b3 synaptogenesis temporally tightly transcriptome verification
Tagcloud (Intersection) ?		ontology