NRCAM and PTPRB

Number of citations of the paper that reports this interaction (PMID 9049255)
26

Data Source:
BioGRID (pull down)
HPRD (in vivo)

		NRCAM	PTPRB
Gene Name		neuronal cell adhesion molecule	protein tyrosine phosphatase, receptor type, B
Image
Gene Ontology Annotations	Cellular Component	Plasma Membrane Integral Component Of Plasma Membrane External Side Of Plasma Membrane Neuron Projection Axon Initial Segment Synapse	Integral Component Of Plasma Membrane Receptor Complex
	Molecular Function	Protein Binding Ankyrin Binding Protein Binding Involved In Heterotypic Cell-cell Adhesion	Transmembrane Receptor Protein Tyrosine Phosphatase Activity Protein Binding
	Biological Process	Angiogenesis Neuron Migration Axonogenesis Axon Guidance Axonal Fasciculation Synapse Assembly Central Nervous System Development Protein Localization Single Organismal Cell-cell Adhesion Neuronal Action Potential Propagation Regulation Of Axon Extension Retinal Ganglion Cell Axon Guidance Heterotypic Cell-cell Adhesion Clustering Of Voltage-gated Sodium Channels Positive Regulation Of Neuron Differentiation	Angiogenesis Protein Dephosphorylation Phosphate-containing Compound Metabolic Process Dephosphorylation Peptidyl-tyrosine Dephosphorylation
Pathways		Interaction between L1 and Ankyrins Axon guidance Neurofascin interactions L1CAM interactions NrCAM interactions
Drugs
Diseases
GWAS		Coffee consumption ( 21876539) Femoral neck bone geometry and menarche (age at onset) ( 23593202)
Protein-Protein Interactions		8 interactors: ANK2 CNTN2 HSPA12A LNX1 MACF1 MAGI3 NFASC PTPRB	10 interactors: CDH5 CNTN1 CNTNAP1 F11R GHR MAGI3 MET NRCAM TEK TNC
Entrez ID		4897	5787
HPRD ID		07207	01474
Ensembl ID		ENSG00000091129	ENSG00000127329
Uniprot IDs		B7Z670 Q14CA1 Q92823	B7ZKS8 F5H3G6 P23467 Q86VA4
PDB IDs		1UEN 1UEY	2AHS 2H02 2H03 2H04 2HC1 2HC2 2I3R 2I3U 2I4E 2I4G 2I4H 2I5X
Enriched GO Terms of Interacting Partners?		Protein Localization To Juxtaparanode Region Of Axon Neuronal Ion Channel Clustering Paranodal Junction Assembly Myelination Axon Ensheathment Neuron Maturation Myelin Assembly Membrane Organization Axon Guidance Anatomical Structure Formation Involved In Morphogenesis Establishment Of Protein Localization To Plasma Membrane Establishment Of Protein Localization To Juxtaparanode Region Of Axon Protein Localization To T-tubule Anatomical Structure Morphogenesis Axonogenesis Cellular Protein Localization Protein Localization To M-band Positive Regulation Of Adenosine Receptor Signaling Pathway T-tubule Organization Cell-cell Junction Assembly Axon Development Cell Morphogenesis Involved In Neuron Differentiation Protein Localization To Endoplasmic Reticulum Chemotaxis Movement Of Cell Or Subcellular Component Neuron Projection Morphogenesis Clustering Of Voltage-gated Potassium Channels Generation Of Neurons Cell Maturation Protein Localization To Plasma Membrane Regulation Of Axonogenesis Protein Targeting To Membrane Neurogenesis Cell Morphogenesis Involved In Differentiation Membrane Depolarization During SA Node Cell Action Potential Cell Junction Assembly SA Node Cell Action Potential Neuron Projection Development Cell-cell Junction Organization Cell Projection Morphogenesis Clustering Of Voltage-gated Sodium Channels Regulation Of Axon Diameter Protein Localization Cell Part Morphogenesis Plasma Membrane Organization Posttranslational Protein Targeting To Membrane Regulation Of Cardiac Muscle Cell Membrane Potential Establishment Of Protein Localization To Membrane Cerebral Cortex GABAergic Interneuron Migration Atrial Cardiac Muscle Cell Action Potential	Cell Adhesion Signaling Cell Communication Cell Development Axon Development Locomotion Neuronal Action Potential Propagation Cell Morphogenesis Involved In Differentiation Neuron Projection Development Movement Of Cell Or Subcellular Component Axon Guidance Mesenchymal-epithelial Cell Signaling Enzyme Linked Receptor Protein Signaling Pathway Neuron Development Positive Regulation Of MAPK Cascade Response To Stimulus Positive Regulation Of Kinase Activity Cell Morphogenesis Axonogenesis Neuron Differentiation Cell Projection Organization Positive Regulation Of Transferase Activity Cell Junction Assembly Cell Morphogenesis Involved In Neuron Differentiation Chemotaxis Cellular Response To Stimulus Cell-cell Junction Organization Positive Regulation Of MAP Kinase Activity Regulation Of MAPK Cascade Positive Regulation Of Signal Transduction Neuron Projection Morphogenesis Anatomical Structure Development Cell Differentiation Positive Regulation Of Metabolic Process Regulation Of Establishment Or Maintenance Of Cell Polarity Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Regulation Of Actin Cytoskeleton Reorganization Positive Regulation Of Protein Phosphorylation Anatomical Structure Morphogenesis Signal Transduction Endothelial Cell Development Positive Regulation Of Protein Serine/threonine Kinase Activity Peptidyl-tyrosine Phosphorylation Regulation Of MAP Kinase Activity Positive Regulation Of Catalytic Activity Regulation Of Kinase Activity Generation Of Neurons Developmental Process Positive Regulation Of Intracellular Signal Transduction Transmission Of Nerve Impulse
Tagcloud ?		affects clustering disorganization dorsal erbb2 erbb3 ganglion glaucoma gliomedin implicate littermates myelin myelination myocilin nav1 nerve nerves neurofascin nodal nodes null ocular ranvier root schwann sciatic sheath stimulates thickness	accumulative acknowledged astrocytoma chi3l1 chr1 chr22 clustering crocc daughter discover ecm exome gbm hereditary lymphatic multiforme narrow pilocytic players pms2 pontine predisposition proximity q12 siblings snvs striking synonymous underline
Tagcloud (Difference) ?		affects disorganization dorsal erbb2 erbb3 ganglion glaucoma gliomedin implicate littermates myelin myelination myocilin nav1 nerve nerves neurofascin nodal nodes null ocular ranvier root schwann sciatic sheath stimulates thickness	accumulative acknowledged astrocytoma chi3l1 chr1 chr22 crocc daughter discover ecm exome gbm hereditary lymphatic multiforme narrow pilocytic players pms2 pontine predisposition proximity q12 siblings snvs striking synonymous underline
Tagcloud (Intersection) ?		clustering